British Journal of Clinical Pharmacology, EarlyView.Aims Almost 5% of pregnancies are affected by immune‐mediated inflammatory diseases (IMIDs). As treatments become available, understanding their use during pregnancy is important. We aimed to describe maternal, pregnancy and infant outcomes among IMID pregnancies exposed to biologic therapies. Methods Using the Merative™ MarketScan® Commercial Database,
Leah K. Flatman +3 more
wiley +1 more source
Interfacility Variation in Diagnosis and Tocolysis for Threatened Preterm Labor and Its Association With Gestational Age Threshold for Neonatal Intensive Care Unit Admission: A Cross-Sectional Survey of Perinatal Centers in the Chugoku-Shikoku Region of Western Japan. [PDF]
J Obstet Gynaecol ResYamane N +9 more
europepmc +1 more source
The placental transfer of nirmatrelvir using the ex vivo human placental perfusion model
British Journal of Clinical Pharmacology, EarlyView.Aims Nirmatrelvir is an effective therapeutic option for COVID‐19 infection and is often administered after symptom onset in pregnant individuals, but few data are available on the associated fetal exposure. The placental perfusion model evaluates maternal–fetal drug transfer across the human placenta and thus can determine fetal drug exposure.
Magdalene Zabek +5 more
wiley +1 more source
Correction: Multicenter study of fetal crown-rump length measurement using 3D ultrasound in assisted reproductive technology pregnancies. [PDF]
J Med Ultrason (2001)Pooh RK +13 more
europepmc +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aim This study aimed to describe the pharmacokinetics (PK) of levetiracetam (LEV) in term neonates treated for neonatal seizures secondary to hypoxic–ischemic encephalopathy (HIE). Methods Fifteen neonates were included and received a loading dose ranging from 30 to 60 mg/kg followed by eight maintenance doses corresponding to one‐fourth of the loading
Léo Mimram +9 more
wiley +1 more source
Assessing kidney function for drug dosing in critical illness
British Journal of Clinical Pharmacology, EarlyView.Kidney‐function assessment supports drug dosing in critical illness but does not directly measure drug clearance. Reduced creatinine generation, fluid shifts and rapidly changing filtration can make creatinine‐based estimates misleading, whereas genuinely augmented renal clearance can cause insufficient drug exposure. These processes can coexist.
Ming‐Shen Lin, Kuo‐Fan Liao
wiley +1 more source
Business Strategy and the Environment, EarlyView.ABSTRACT We examine the effect of chief executive officers' (CEOs') career horizons on environmental, social, and governance (ESG) performance and investigate how hard cues influence this performance effect. Our study offers a new perspective of CEO career horizon as a mechanism that enables firms to improve their ESG performance when occupying a ...
Sofia Angelidou +2 more
wiley +1 more source
The Impact of Telemedicine Interventions on Maternal and Fetal Outcomes in Women With Gestational Diabetes: Systematic Review and Meta-Analysis of Randomized Controlled Trials. [PDF]
J Med Internet ResHe H +7 more
europepmc +1 more source
Quantification of Palmar and Digital Epidermal Thickness and Sweat Duct Density
Clinical Anatomy, EarlyView.ABSTRACT Palmar digital skin, with its high density of epidermal sweat glands and unique stratum corneum, derives its autonomic innervation from peripheral nerves. Understanding the changes to these structures could serve as objective proxy markers following peripheral nerve injury and interventions to promote regeneration.
Elizabeth Jones +7 more
wiley +1 more source
Real-world discrimination and incremental value of first-trimester placental growth factor for hypertensive disorders of pregnancy: a retrospective Chinese cohort. [PDF]
Front Endocrinol (Lausanne)Jiang L, Chai M, Xia Y.
europepmc +1 more source