A Novel Cultivation System for Germ Cell Proliferation and Sustaining Whole Testicular Niche
A hydrogel microneedle‐based system enables whole testicular cultivation, supporting spermatogonial proliferation and enhancing spermatogenesis in vitro. This ‘whole testicular spermatogonia pool’ (WTSP) significantly increases spermatid production and fertility potential in mice. This system also promotes spermatogonial expansion in human fetal testes,
Yu Xia+14 more
wiley +1 more source
Background It is unclear whether the effects of abnormal gestational weight gain (GWG) on birth outcomes are differently in women with different maternal ages.
Yidi Wang+6 more
doaj +1 more source
ObjectivesPrematurity, being small for gestational age and early neonatal ward admission are the major neonatal conditions that may interfere with breastfeeding supportive practices in infants born at gestational age ≥35+0 weeks.
Freja Marie Nejsum+5 more
doaj +1 more source
A multicountry randomized controlled trial of comprehensive maternal nutrition supplementation initiated before conception: the Women First trial. [PDF]
Background: Reported benefits of maternal nutrition supplements commenced during pregnancy in low-resource populations have typically been quite limited.
Ali, Sumera A.+20 more
core +1 more source
Gestational diabetes mellitus- right person, right treatment, right time? [PDF]
Background: Personalised treatment that is uniquely tailored to an individual’s phenotype has become a key goal of clinical and pharmaceutical development across many, particularly chronic, diseases.
Lindsay, Robert S.+2 more
core +1 more source
This study uncovers a novel mechanism and therapeutic targets in obstetric antiphospholipid syndrome (OAPS). Antiphospholipid antibody/ß2‐glycoprotein I complex boosts CCL2 and TNF‐α expression in decidual macrophages via TLR4‐NF‐κB. CCL2 accumulates on endothelial surfaces via ACKR1, recruiting monocyte‐derived CCR2+ macrophages, driving inflammation,
Rui Gao+13 more
wiley +1 more source
Mean Duration of Pregnancy in Spontaneous Deliveries in Ahwaz University Affiliated Hospitals in 2007 [PDF]
Background & Aims: Accurate knowledge about gestational age is very important in taking decision for pregnancy management and termination. According to Naegele’s rule the length of pregnancy is 280 days after LMP and according to studies performed in ...
M Barati+3 more
doaj
Estimation of causal effects using instrumental variables with nonignorable missing covariates: Application to effect of type of delivery NICU on premature infants [PDF]
Understanding how effective high-level NICUs (neonatal intensive care units that have the capacity for sustained mechanical assisted ventilation and high volume) are compared to low-level NICUs is important and valuable for both individual mothers and ...
Lorch, Scott A.+2 more
core +3 more sources
RelA Inhibits Embryonic Myogenesis by Coordinately Regulating a Novel Distal Enhancer of Myogenin
Maternal obesity (MO) accounts for more than 40% of pregnancies in the United States, induces inflammation, and impairs embryonic myogenesis, known to program muscle dysfunction in offspring. Inflammation enhances the binding of RelA to a novel distal enhancer located 4 kb upstream of myogenin promoter to inhibit embryonic myogenesis, which is ...
Md Nazmul Hossain+9 more
wiley +1 more source
MOTHERS’ HYPERTENSION AND NEONATAL BIRTH WEIGHT
Pregnancy induced hypertension has impacts on birth weight in different gestational ages, and deciding on preventive modalities is mainly based on comprehension of birth weight in different gestational ages.
M. Madadzadeh+3 more
doaj