Results 71 to 80 of about 5,469,442 (208)

Early‐Life Manganese Overexposure Activates Microglial Phagocytosis through the YY1/TREM2 Axis Leading to Hippocampal Synaptic Remodeling in Mice

Advanced Science, EarlyView.
Early‐life manganese exposure induces behavioral deficits and aberrant hippocampal synaptic remodeling by enhancing microglial phagocytosis in young adult male mice. Mechanistically, manganese promotes Yin Yang 1 (YY1)/triggering receptor expressed on myeloid cells 2 (TREM2) signaling through enhanced HIF1α‐mediated transcription and suppressed SMURF2 ...
Keyu Chen, Bin He, Kuan Liu, Zhuo Ma, Bin Xu   +4 more
wiley   +1 more source

Gestational age–dependent effects of intrauterine inflammation, delivery mode, and fetal growth on respiratory morbidity in preterm neonates

Frontiers in Pediatrics
IntroductionRespiratory morbidity in preterm neonates is influenced by both lung immaturity and antenatal environmental exposures. Because lung maturation continue throughout late gestation, the effects of these factors may vary according to gestational ...
Kyoko Yokoi, Osuke Iwata, Sachiko Iwata, Satoru Kobayashi, Kozue Kasukabe, Yasuhisa Nakamura, Kazuyuki Yamamoto, Takenori Katou, Shinji Saitoh, Haruo Goto   +9 more
doaj   +1 more source

Mean Duration of Pregnancy in Spontaneous Deliveries in Ahwaz University Affiliated Hospitals in 2007 [PDF]

Journal of Kerman University of Medical Sciences, 2009
Background & Aims: Accurate knowledge about gestational age is very important in taking decision for pregnancy management and termination. According to Naegele’s rule the length of pregnancy is 280 days after LMP and according to studies performed in ...
M Barati, F Moramazi, S Masihi, N SHabazian   +3 more
doaj  

Birthweight-for-gestational-age z -scores are associated with early childhood cardiometabolic health in the Peri/Postnatal Epigenetic Twin Study

, 2023
t Birthweight has been consistently related to risk of cardiometabolic disorders in later life. Twins are at higher risk of low birthweight than singletons, so understanding the links between birthweight and cardiometabolic health may be particularly ...
K J Scurrah (13310223), Jeffrey Craig (13065240), Debbie Ashtree (13059327), M J Silva (13393089), C Sun (7673477)   +4 more
core  

Structural Control of Stromal‐Immune Coupling by COL24A1 Underlies Pregnancy Maintenance

Advanced Science, EarlyView.
COL24A1 emerges as a collagen‐associated regulator of maternal‐fetal interface homeostasis. Its deficiency promotes a maladaptive TIMP1‐high stromal state, impaired ECM turnover, collagen accumulation, and stromal–immune dysregulation, contributing to pregnancy loss.
Teng Wu, Lingling Xie, Wenyi Liu, Hanjie Mo, Chengshu Xie, Jing Tang, Zhaorui Wang, Peixuan Lan, Jianping Zhang, Jie Gao, Qionglan Tang, Chunwei Cao, Hui Chen   +12 more
wiley   +1 more source

CLINICAL STUDY OF RESPIRATORY DISTRESS SYNDROME IN AL-KADHIMIYA TEACHING HOSPITAL

The Iraqi Journal of Medical Sciences, 2016
Background:Respiratory distress syndrome (RDS) or hyaline membrane disease (HMD) is an acute lung disease of the newborn caused by surfactant deficiency. It is Seen primarily in neonates younger than 36-38 weeks of gestational age weighing less than 2500
Lamia AK Al-Saady, Hayder H Al-Musawi
doaj   +4 more sources

Human placental growth hormone is increased in maternal serum at 20 weeks of gestation in pregnancies with large-for-gestational-age babies

, 2017
To investigate the relationship between maternal serum concentrations of placental growth hormone (GH-V), insulin-like growth factor (IGF)-1 and 2, IGF binding proteins (IGFBP)-1 and 3 and birth weight in appropriate-for-gestational-age (AGA), large-for ...
Beatrix Jones (3696325), Mark H. Vickers (6899263), Shutan Liao (3696328), Rennae S. Taylor (7739246), Jo K. Perry (3696319), Mhoyra Fraser (3696322), Lesley M. E. McCowan (7710743), Philip N. Baker (338976)   +7 more
core   +2 more sources

Adjusted analysis of risk of large-for-gestational-age, total cesarean section and operative vaginal delivery after excluding women with a GDM diagnosis based on WHO-1999 criteria.

, 2023
Adjusted analysis of risk of large-for-gestational-age, total cesarean section and operative vaginal delivery after excluding women with a GDM diagnosis based on WHO-1999 criteria.
Line Sletner (292376), Signe Nilssen Stafne (5089160), Are Hugo Pripp (7356923), Nina Cecilie Øverby (11410151), Linda Reme Sagedal (4621729), Anam Shakil Rai (16503263), Anne Karen Jenum (9535089), Elisabeth Qvigstad (398475)   +7 more
core   +1 more source

Maternal Hyperglycemia Disrupts Cerebral Cortex Development Through the Foxp1‐Dll1‐Notch Axis

Advanced Science, EarlyView.
Maternal hyperglycemia disrupts offspring cortical development through a Foxp1–Dll1–Notch signaling axis. In a PGDM mouse model, intrauterine hyperglycemia decreases cortical thickness and perturbs neuronal layering by downregulating Foxp1, which transcriptionally regulates the Notch ligand Dll1.
Longkai He, Ya Jin, Guosheng Liu, Hao Liu, Xinyi Zhu, Weipeng Xu, Wei Li, Meiyao He, Yao Shen, Bingxiao Li, Xuesong Yang, Xiaoyu Wang, Shasha Han   +12 more
wiley   +1 more source

Arhgef1 Deletion Disrupts Early Cortical Neurogenesis via PAK1 Overactivation and Causes Motor Dysfunction in Adulthood

Advanced Science, EarlyView.
ARHGEF1 plays a pivotal role in both embryonic cortical neurogenesis and adult motor function. During early development, it governs genesis of deep‐layer cortical neurons by negatively regulating RAC1/CDC42‐PAK1‐Cofilin signaling. In adulthood, ARHGEF1 is important for the maintenance of neuronal morphology and activity in the motor cortex, ensuring ...
Liuren Li, Xuanyue Ma, Zhenyu Ding, Bang Sun, Linglin Liu, Hei Matthew Yip, Wei Wang, Tianying Wu, Yuan Guo, Yinghui Peng, Shiqing Zhang, Jacque Pak Kan Ip, Li Zhang, Keshen Li, Lei Shi   +14 more
wiley   +1 more source