Results 61 to 70 of about 349,129 (310)

Real‐World Trends in Prenatal Antirheumatic Drug Utilization in Ontario, Canada: A Cross‐Sectional Time‐Series Analysis

Arthritis Care &Research, EarlyView.
Objective This study aimed to describe real‐world trends in preconception and prenatal use of antirheumatic drugs among pregnant individuals with rheumatic diseases in Ontario, Canada. Methods We conducted a time‐series analysis using repeated cross‐sectional data to examine annual patterns of disease‐modifying antirheumatic drug (DMARD) use among ...
Shenthuraan Tharmarajah, Swaleh Hussain, Sara J. T. Guilcher, Lisa M. McCarthy, Dharini Mahendira, Howard Berger, Mina Tadrous   +6 more
wiley   +1 more source

Performance of Intergrowth 21st Growth Charts in the Diagnosis of Small and Large for Gestational Age in Term and Preterm Newborns

Acta Médica Portuguesa, 2020
Introduction: Birth weight is a major contributor to neonatal morbidity and mortality and is associated with chronic diseases in adulthood. This study aimed to evaluate the use of Intergrowth 21st instead of the Fenton & Kim 2013 growth charts in the ...
Bárbara Marques, Rosa Martins, Teresa Rodrigues, Graça Oliveira, Margarida Abrantes   +4 more
doaj   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Change of maternal weight gain trajectory following lifestyle interventions for gestational diabetes and its impact on abnormal infant birthweight: an observational study based on longitudinal weight measurements

BMC Pregnancy and Childbirth
Background Restricted gestational weight gain (GWG) following lifestyle interventions for gestational diabetes mellitus (GDM) has been observed in clinical trials but not been explicitly confirmed in real-world clinical settings.
Juan Li, Chuanzi Yang, Kuanrong Li
doaj   +1 more source

Association of chronic hypertension with birth of small-for-gestational-age neonate [PDF]

, 2017
Objective: To examine the effect of chronic hypertension (CH), with and without superimposed preeclampsia (PE), on the incidence of small for gestational age (SGA) neonates, and explore possible mechanisms for such association. Methods: The data for the
Panaitescu, A.M., Akolekar, R., Nicolaides, K.H., Baschat, A.A., Syngelaki, A.   +4 more
core   +1 more source

Sex‐Specific Regulation of Glycemic Homeostasis by Theabrownin from Pu‐erh Tea

Advanced Science, EarlyView.
Pu‐erh tea's key component, theabrownin (TB), lowers blood glucose in a sex‐specific manner. In females, estrogen boosts intestinal MUC2 production, which dramatically enhances TB's ability to inhibit the carbohydrate‐digesting enzyme α‐glucosidase.
Yang Li, Junliang Kuang, Dan Zheng, Jieyi Wang, Kun Ge, Chun Qu, Xiaojiao Zheng, Zhenxing Ren, Fengjie Huang, Mingliang Zhao, Yimin Sun, Huiheng Zhang, Keke Ding, Xixi Xia, Yajun Tang, Lu Liu, Jian Zhou, Fei Gao, Xiaohui Ma, Yongquan Xu, Guoxiang Xie, Aihua Zhao, Wei Jia   +22 more
wiley   +1 more source

Transgenerational transmission of small‐for‐gestational age [PDF]

Ultrasound in Obstetrics & Gynecology, 2019
ABSTRACTObjectiveTo evaluate the transgenerational transmission of small‐for‐gestational age (SGA).MethodsThis was a cohort study of a random sample of 2043 offspring delivered between 1975 and 1993 at Hospital Sant Joan de Déu in Barcelona. Exclusion criteria were multiple pregnancy, aneuploidy or genetic syndrome, major birth defects, severe mental ...
Á. Sepúlveda‐Martínez, M. Rodríguez‐López, F. Paz Y Miño, G. Casu, F. Crovetto, E. Gratacós, F. Crispi   +6 more
openaire   +5 more sources

Gestational weight gain and body mass index in children: results from three german cohort studies. [PDF]

, 2012
Previous studies suggested potential priming effects of gestational weight gain (GWG) on offspring's body composition in later life. However, consistency of these effects in normal weight, overweight and obese mothers is less clear.
Manfred J Müller, Kries, Rüdiger von, Nehring, I., Rüdiger von Kries, Brenner Hermann, Rzehak, P., Weck, M., Weck Melanie, Peter Rzehak, Beyerlein, A., Weck, Melanie, Joachim Heinrich, Melanie Weck, Wabitsch, Martin, Plachta-Danielzik, S., Heinrich, Joachim, von Kries, R., Hermann Brenner, Müller, M.J., Müller Manfred J., Plachta-Danielzik, Sandra, Heinrich, J., Beyerlein Andreas, Müller, Manfred J., Rzehak, Peter, Wabitsch, M., Nehring Ina, Rothenbacher, D., von Kries Rüdiger, Rzehak Peter, Rothenbacher, Dietrich, Brenner, Hermann, Beyerlein, Andreas, Andreas Beyerlein, Wabitsch Martin, Brenner, H., Nehring, Ina, Sandra Plachta-Danielzik, Dietrich Rothenbacher, Heinrich Joachim, Ina Nehring, Rothenbacher Dietrich, Martin Wabitsch, Plachta-Danielzik Sandra   +43 more
core   +1 more source