Results 41 to 50 of about 506,300 (298)

Caesarean section and risk of unexplained stillbirth in subsequent pregnancy [PDF]

, 2003
Background Caesarean section is associated with an increased risk of disorders of placentation in subsequent pregnancies, but effects on the rate of antepartum stillbirth are unknown.
Alfirevic, Ananth, Campbell, Castro, Cnattingius, Cole, Cole, Feldman, Gordon CS Smith, Grambsch, Hannah, Hemminki, Hosmer, Jensen, Jill P Pell, Kendrick, Kingdom, Lees, Lieberman, Lydon-Rochelle, Lydon-Rochelle, Macara, Mailer, McIlwaine, McLoone, Moore, Morrison, Parrish, Pocock, Porreco, Rasmussen, Richard Bobbie, Smith, Smith, Soper, Thorpe-Beeston, Yudkin   +36 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Mifepristone Antagonization With Progesterone to Prevent Medical Abortion: A Randomized Controlled Trial. [PDF]

, 2020
ObjectiveTo estimate the efficacy and safety of mifepristone antagonization with high-dose oral progesterone.MethodsWe planned to enroll 40 patients in a double-blind, placebo-controlled, randomized trial.
Chen, Melissa J, Creinin, Mitchell D, Dalton, Laura, Hou, Melody Y, Steward, Rachel   +4 more
core   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Consistent cord blood DNA methylation signatures of gestational age between South Asian and white European cohorts

Clinical Epigenetics
Background Epigenetic modifications, particularly DNA methylation (DNAm) in cord blood, are an important biological marker of how external exposures during gestation can influence the in-utero environment and subsequent offspring development. Despite the
Wei Q. Deng, Marie Pigeyre, Sandi M. Azab, Samantha L. Wilson, Natalie Campbell, Nathan Cawte, Katherine M. Morrison, Stephanie A. Atkinson, Padmaja Subbarao, Stuart E. Turvey, Theo J. Moraes, Piush Mandhane, Meghan B. Azad, Elinor Simons, Guillaume Pare, Sonia S. Anand   +15 more
doaj   +1 more source

Characteristics Overview of Mother with Perinatal Death at Dr. Soetomo Hospital in 2015 [PDF]

, 2016
Objectives: to determine the frequency distribution of perinatal mortality and maternal characteristic features in terms of age, parity, gestational age and pregnancy complications in Dr.Soetomo Hospital Surabaya in 2015.
Haslinda, Y. (Yulisa), Prasetyo, B. (Budi)   +1 more
core  

Early life factors and risk of childhood rhabdomyosarcoma. [PDF]

, 2013
Although little is known about etiology of childhood rhabdomyosarcoma (RMS), early life factors are suspected in the etiology. We explored this hypothesis using linked data from the California Cancer Registry and the California birth rolls.
Anshu eShrestha, Anshu eShrestha, Beate eRitz, Christina A Lombardi, Julia eHeck, Michelle eWilhelm, Simona eOgnjanovic   +6 more
core   +2 more sources

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Comparative Study of Cord Lipid Profile in Small for Gestational Age and Appropriate for Gestational Age Newborn [PDF]

Iranian Journal of Neonatology, 2017
Background: This study was conducted to compare the cord blood lipid profile in term small for gestation (SGA) and appropriate for gestational age (AGA) babies as determination of cord blood lipid profile is useful screening tool for early detection of ...
Sunita Arora, Shifali Gupta, Pushpjeet Sheemar   +2 more
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source