Results 21 to 30 of about 14,270 (275)

Cross-cohort mixture analysis: a data integration approach with applications on gestational age and DNA-methylation-derived gestational age acceleration metrics [PDF]

, 2023
ABSTRACTBackgroundData integration of multiple epidemiologic studies can provide enhanced exposure contrast and statistical power to examine associations between environmental exposure mixtures and health outcomes. Extant studies have combined population studies and identified an overall mixture-outcome association, without accounting for differences ...
Elena Colicino, Roberto Ascari, Hachem Saddiki, Francheska M. Merced‐Nieves, Nicolò Foppa Pedretti, Kathi Huddleston, Robert O. Wright, Rosalind J. Wright, Child Health Outcomes   +8 more
openalex   +2 more sources

Epigenetic age and pregnancy outcomes: GrimAge acceleration is associated with shorter gestational length and lower birthweight [PDF]

Clinical Epigenetics, 2020
Abstract Background Advanced biological aging, as measured by epigenetic aging indices, is associated with early mortality and morbidity. Associations between maternal epigenetic aging indices in pregnancy and pregnancy outcomes, namely gestational length and birthweight, have not been assessed.
Kharah M. Ross, Judith Carroll, Steve Horvath, Calvin J. Hobel, Mary Coussons‐Read, Christine Dunkel Schetter   +5 more
openalex   +6 more sources

Accelerations of the human fetal heart rate at 38 to 40 weeks' gestational age

American Journal of Obstetrics and Gynecology, 1984
In order to document the normal structure and pattern of fetal heart rate accelerations near term, we measured fetal heart rate and fetal movements for 24-hour observation intervals in 12 healthy pregnant women at 38 to 40 weeks' gestation. There were 34 accelerations per hour on the average with a mean amplitude of 22.8 bpm and a mean duration of 40.7
Odd Harald Jensen
  +7 more sources

Maternal psychosocial risk factors and offspring gestational epigenetic age acceleration in a South African birth cohort study [PDF]

, 2018
Epigenetic age (EA) acceleration is associated with higher risk of chronic disease and mortality in adults. However, little is known about whether and how in utero exposures might shape gestational EA acceleration at birth. We aimed to explore associations between maternal psychosocial risk factors and offspring gestational EA acceleration at birth in
Nastassja Koen, Meaghan J. Jones, Raymond T. Nhapi, Kirsten A. Donald, Whitney Barnett, Nadia Hoffman, Julia L. MacIsaac, Alexander M. Morin, David Lin, Michael S. Kobor, Karestan C. Koenen, Heather J. Zar, Dan J. Stein   +12 more
openalex   +2 more sources

Placental epigenetic clocks derived from crowdsourcing: Implications for the study of accelerated aging in obstetrics [PDF]

iScience
Summary: Epigenetic gestational age acceleration has been implicated in obstetric syndromes including preeclampsia, yet robust conclusions require accurate and unbiased epigenetic age models.
Gaurav Bhatti, Herdiantri Sufriyana, Roberto Romero, Tushar Patel, Fasil Tekola-Ayele, Ibrahim Alsaggaf, Nardhy Gomez-Lopez, Emily C.Y. Su, Bogdan Done, Steve Hoffmann, Alena van Bömmel, Cen Wan, Jake Albrecht, Charles Novak, Tinnakorn Chaiworapongsa, Marina Sirota, Nima Aghaeepour, Gustavo Stolovitzky, David R. Bryant, Adi L. Tarca   +19 more
doaj   +2 more sources

Analysis of prenatal medication use and placental epigenetic gestational age in extremely low gestational age newborns (ELGANs) highlight relationships to aspirin use during pregnancy [PDF]

Clinical Epigenetics
Background Several maternal exposures such as acetaminophen during pregnancy have been previously associated with altered placental CpG methylation. Epigenetic gestational age measures biological aging using DNA methylation from gestational tissues such ...
Katelyn K. Huff, Catherine M. Bulka, Jeliyah Clark, Kyle R. Roell, T. Michael O’Shea, Rebecca C. Fry   +5 more
doaj   +2 more sources

Association between placental epigenetic age acceleration and early postnatal growth patterns [PDF]

Scientific Reports
Placental gestational age acceleration (GAA) is the difference between the actual gestational age (GA) at birth and their estimated epigenetic gestational age (EGA), which is calculated from placental DNA methylation.
Priyadarshni Patel, Angela Shen, Cynthia Perez, Elizabeth M. Kennedy, Kartik Shankar, Kevin J. Pearson, Aline Andres, Todd M. Everson   +7 more
doaj   +2 more sources

Immune pathways and perinatal environmental exposures contribute to epigenetic gestational age prediction and acceleration

AbstractDNA methylation (DNAm), capturing biological gestational age (GA) and epigenetic gestational age acceleration (EGAA), can be modified by environmental exposures. The Asthma&Allergy array is a new DNAm array developed with content focused on asthma and allergy loci.
Amy Eapen, Ian M. Loveless, Mingming Pan, Xiaoyu Liang, Audrey Urquhart, Jennifer K. Straughen, Andrea E. Cassidy‐Bushrow, Alexandra R. Sitarik, Neil Simmerman, Emma E. Thompson, Leah C. Kottyan, Carole Ober, Christine Cole Johnson, Edward M. Zoratti, Albert M. Levin   +14 more
openalex   +3 more sources

Reference values of fetal pulmonary artery branch from 18 to 40 weeks of gestation [PDF]

Scientific Reports
The information and the reference values determined by gestational age of pulmonary vascular resistance parameters of the branch pulmonary arteries measured by Doppler ultrasonography are quite scarce.
Sasiwimon Phuakpoolpol, Thotsapon Trakulmongkichkarn, Sanpon Diawtipsukon, Saowapak Junhasavasdikul   +3 more
doaj   +2 more sources

Investigating asymmetry in fetal and maternal heart rate accelerations and decelerations [PDF]

Scientific Reports
This study investigates the asymmetry in heart rate (HRA) during fetal development in the fetus and mother. R-R intervals from noninvasive fetal and maternal ECG signals from 102 pregnant women whose gestational age ranges from 20 to 40 weeks were ...
Rafał Pawłowski, Fatimah Al-Ani, Amna Samjeed, Katarzyna Buszko, Ahsan Khandoker   +4 more
doaj   +2 more sources