Results 11 to 20 of about 5,484,661 (188)

Maternal Vitamin D Deficiency Is a Risk Factor for Infants' Epigenetic Gestational Age Acceleration at Birth in Japan: A Cohort Study. [PDF]

Nutrients
Background/Objectives: The DNA methylation of neonatal cord blood can be used to accurately estimate gestational age. This is known as epigenetic gestational age. The greater the difference between epigenetic and chronological gestational age, the greater the association with an inappropriate perinatal fetal environment and development.
Kawai T, Jwa SC, Ogawa K, Tanaka H, Aoto S, Kamura H, Morisaki N, Fujiwara T, Hata K.   +8 more
europepmc   +4 more sources

Epigenetic age and pregnancy outcomes: GrimAge acceleration is associated with shorter gestational length and lower birthweight [PDF]

Clinical Epigenetics, 2020
Abstract Background Advanced biological aging, as measured by epigenetic aging indices, is associated with early mortality and morbidity. Associations between maternal epigenetic aging indices in pregnancy and pregnancy outcomes, namely gestational length and birthweight, have not been assessed.
Kharah M. Ross, Judith E. Carroll, Steve Horvath, Calvin J. Hobel, Mary E. Coussons-Read, Christine Dunkel Schetter   +5 more
openaire   +7 more sources

Gestational age acceleration is associated with epigenetic biomarkers of prenatal physiologic stress exposure. [PDF]

Clin Epigenetics, 2022
Abstract Background Physiological maternal stress response, such as imbalance in the glucocorticoid pathway and immune system seems to be mediated by DNA methylation (DNAm) and might translate intrauterine stress exposures into phenotypic changes in a sex-specific manner.
Euclydes V, Gomes C, Gouveia G, Gastaldi VD, Feltrin AS, Camilo C, Vieira RP, Felipe-Silva A, Grisi S, Fink G, Brentani A, Brentani H.   +11 more
europepmc   +4 more sources

Cross-Cohort Mixture Analysis: A Data Integration Approach With Applications on Gestational Age and DNA-Methylation-Derived Gestational Age Acceleration Metrics. [PDF]

Biom J
ABSTRACT Data integration of multiple studies can provide enhanced exposure contrast and statistical power to examine associations between environmental exposure mixtures and health outcomes. Extant research has combined populations and identified an overall mixture–outcome association, without accounting for differences across ...
Colicino E, Ascari R, Saddiki H, Merced-Nieves F, Foppa Pedretti N, Huddleston K, Wright RO, Wright RJ, Program Collaborators for Environmental Influences on Child Health Outcomes.   +8 more
europepmc   +4 more sources

Amplification of the epigenetic (gestational) age acceleration signal [PDF]

, 2021
ABSTRACT Background Epigenetic (gestational) age acceleration (E(G)AA) is associated with environmental exposures and health outcomes in humans. However, E(G)AA is the residual term from a regression of epigenetic age (outcome) on chronological (gestational) age (predictor) and therefore strongly ...
Yunsung Lee, Jon Bohlin
openaire   +1 more source

Cumulative stress, PTSD, and emotion dysregulation during pregnancy and epigenetic age acceleration in Hispanic mothers and their newborn infants

Epigenetics, 2023
Pregnancy can exacerbate or prompt the onset of stress-related disorders, such as post-traumatic stress disorder (PTSD). PTSD is associated with heightened stress responsivity and emotional dysregulation, as well as increased risk of chronic disorders ...
Seyma Katrinli, Alicia K Smith, Stacy S. Drury, Jonathan Covault, Julian D. Ford, Vijender Singh, Bo Reese, Amy Johnson, Victoria Scranton, Pamela Fall, Margaret Briggs-Gowan, Damion J Grasso   +11 more
doaj   +1 more source

DNA methylation age at birth and childhood: performance of epigenetic clocks and characteristics associated with epigenetic age acceleration in the Project Viva cohort

Clinical Epigenetics, 2023
Background Epigenetic age acceleration (EAA) and epigenetic gestational age acceleration (EGAA) are biomarkers of physiological development and may be affected by the perinatal environment.
Anne K. Bozack, Sheryl L. Rifas-Shiman, Diane R. Gold, Zachary M. Laubach, Wei Perng, Marie-France Hivert, Andres Cardenas   +6 more
doaj   +1 more source

Placental epigenetic gestational aging in relation to maternal sociodemographic factors and smoking among infants born extremely preterm: a descriptive study

Epigenetics, 2022
Social determinants of health (SDoH) are defined as the conditions in which people are born, grow, live, work, and age. The distribution of these conditions is influenced by underlying structural factors and may be linked to adverse pregnancy outcomes ...
Jeliyah Clark, Catherine M. Bulka, Chantel L. Martin, Kyle Roell, Hudson P. Santos, T. Michael O’Shea, Lisa Smeester, Rebecca Fry, Radhika Dhingra   +8 more
doaj   +1 more source

Accelerated epigenetic age at birth and child emotional and behavioura development in early childhood: a meta-analysis of four prospective cohort studies in ECHO

Epigenetics, 2023
Background: ‘Epigenetic clocks’ have been developed to accurately predict chronologic gestational age and have been associated with child health outcomes in prior work. Methods: We meta-analysed results from four prospective U.S cohorts investigating the
Ashley Y. Song, Catherine M. Bulka, Sierra S. Niemiec, Katerina Kechris, Kristen E. Boyle, Carmen J. Marsit, T. Michael O’Shea, Rebecca C. Fry, Kristen Lyall, M. Daniele Fallin, Heather E. Volk, Christine Ladd-Acosta   +11 more
doaj   +1 more source

Kidney growth in small-for-gestational-age infants: evidence of early accelerated renal growth [PDF]

Nephrology Dialysis Transplantation, 2006
Very few data are available on longitudinal renal growth in small for gestational age (SGA) infants born at term. The aim of this prospective study was to estimate comparatively the renal growth in SGA infants and in infants born appropriate for gestational age (AGA) during the first 2 years of life.The study comprised groups of SGA and AGA infants ...
Giapros, V., Drougia, A., Hotoura, E., Papadopoulou, F., Argyropoulou, M., Andronikou, S.   +5 more
openaire   +3 more sources