Results 81 to 90 of about 14,270 (275)

Gestational diabetes [PDF]

open access: yes, 2017
Gestational diabetes mellitus (GDM) is defined as hyperglycaemia that is diagnosed for the first time in the second or third trimester of pregnancy. It occurs in 1 in 7 pregnancies worldwide and is associated with increased risk of adverse perinatal ...
Murphy, Helen R.   +2 more
core   +1 more source

Ultrasound Activated Piezoelectric Dural Patches to Drive Endogenous Neural Stem Cell–Mediated Repair Traumatic Brain Injury

open access: yesAdvanced Science, EarlyView.
This study presents a wireless, non‐invasive strategy for neural repair by developing a biodegradable piezoelectric dural patch that, under transcranial ultrasound, generates localized electrical fields to drive endogenous neural stem cells toward neuronal differentiation and functional integration.
Pengbo Zhou   +7 more
wiley   +1 more source

Accelerated fetal growth in early pregnancy and risk of severe large‐for‐gestational‐age and macrosomic infant: a cohort study in a low‐risk population [PDF]

open access: yesActa Obstetricia et Gynecologica Scandinavica, 2017
AbstractIntroductionOur objective was to examine the association between fetal growth in early pregnancy and risk of severe large‐for‐gestational‐age (LGA) and macrosomia at birth in a low‐risk population.Material and methodsCohort study that included 68 771 women with non‐anomalous singleton pregnancies, without history of diabetes or hypertension ...
Marija Simic   +2 more
openaire   +2 more sources

Combined Long‐Read Genome and Transcriptome Sequencing Establishes Novel Variants in MEGF8 as the Cause for Carpenter Syndrome Type 2

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Carpenter syndrome type 2 (CRPT2) is a rare autosomal recessive disease mainly characterized by craniosynostosis and polysyndactyly. CRPT2 is the rarer subtype of Carpenter syndrome (CRPTS) and is caused by biallelic variants in the multiple epidermal growth factor‐like domains 8 gene (MEGF8).
Kiana Rashidi   +11 more
wiley   +1 more source

Early exposure to environment sounds and the development of cortical auditory evoked potentials of preterm infants during the first 3 months of life

open access: yesBMC Research Notes, 2020
Objective Preterm infants are exposed earlier than their term counterparts to unattenuated sounds from the external environment during the sensitive period of the organization of the auditory cortical circuitry.
Hannalice Gottschalck Cavalcanti   +5 more
doaj   +1 more source

β-Cell failure in type 2 diabetes: a case of asking too much of too few? [PDF]

open access: yes, 2013
The islet in type 2 diabetes (T2DM) is characterized by a deficit in β-cells, increased β-cell apoptosis, and extracellular amyloid deposits derived from islet amyloid polypeptide (IAPP). In the absence of longitudinal studies, it is unknown if the low β-
Butler, Peter C   +4 more
core   +1 more source

Optimization and verification of high‐fat diet formulation for establishing a rat model of obesity‐related precocious puberty

open access: yesAnimal Models and Experimental Medicine, EarlyView.
We identified 45% HFD as the optimal formulation to establish a juvenile rat model of obesity‐related precocious puberty. It elicits robust phenotypic (early vaginal opening, obesity), histological (advanced ovarian development), and endocrine (elevated HPG axis hormones) alterations, with leptin‐mediated GnRH secretion as a core mechanistic driver ...
Jiayi Gong   +5 more
wiley   +1 more source

Evaluating treatment effectiveness in small for gestational age children by optimizing growth hormone dose

open access: yesMìžnarodnij Endokrinologìčnij Žurnal, 2019
Background. According to world statistics, about 5–10 % of newborns are small for gestational age (SGA). They can have inadequate rates of postnatal growth during first two years of life.
O.V. Bolshova, N.M. Muz
doaj   +1 more source

Equine models in translational medicine: A comparative approach to human health

open access: yesAnimal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh   +1 more
wiley   +1 more source

An evolutionary genomic approach to identify genes involved in human birth timing. [PDF]

open access: yesPLoS Genetics, 2011
Coordination of fetal maturation with birth timing is essential for mammalian reproduction. In humans, preterm birth is a disorder of profound global health significance.
Jevon Plunkett   +22 more
doaj   +1 more source

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