Results 91 to 100 of about 424,338 (262)

Maternal obesity during pregnancy disrupts iron homeostasis and promotes fetal hypoxia in the mouse

The Journal of Physiology, Volume 604, Issue 1, Page 566-581, 1 January 2026.
Abstract figure legend Maternal obesity induces systemic inflammation and high insulin and leptin levels, potentially promoting hepcidin release into circulation and thus iron sequestration in specific tissue compartments. This results in low iron availability in the mother with potential detrimental effects on the fetus, including hypoxia.
Adriana Córdova‐Casanova, Isabella Inzani, Antonia Hufnagel, Dino A Giussani, Denise S. Fernandez‐Twinn, Susan E Ozanne   +5 more
wiley   +1 more source

Non-Gestational Choriocarcinoma with Widespread Metastases Presenting with Type 1 Respiratory Failure in a 39-Year-Old Female: Case Report and Review of the Literature

Case Reports in Oncology, 2018
Introduction: Non-gestational choriocarcinoma (NGCC) is an extremely rare cancer. We report a case presenting in extremis. Case Report: A 39-year-old woman presented with type 1 respiratory failure with a 1-month history of breathlessness.
L. Stockton, Elizabeth Green, B. Kaur, E. de Winton   +3 more
semanticscholar   +1 more source

Placental DEPTOR as a stress sensor during pregnancy [PDF]

, 2011
The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Non-Commercial Licence (http://creativecommons.org/licenses/by-nc/2.5/) which permits unrestricted non-commercial use, distribution and ...
Gidron, Y, Goumenou, A, Karteris, E, Mparmpakas, D, Zachariades, E   +4 more
core   +2 more sources

Downregulation of Chromosome 19 miRNA Cluster and the Tumor‐Suppressive Role of miR‐517a‐3p in Choriocarcinoma

Cancer Science, Volume 116, Issue 12, Page 3473-3486, December 2025.
Chromosome 19 microRNA cluster was downregulated in choriocarcinoma compared with complete hydatidiform mole. miR‐517a‐3p reduced the proliferation, migration, and invasion abilities of choriocarcinoma cell lines. Downregulation of SRSF1, targeted by miR‐517a‐3p, suppressed the malignant potential of choriocarcinoma cell lines. ABSTRACT Choriocarcinoma
Yuki Nishiko, Kosuke Yoshida, Yuko Yasui, Akira Yokoi, Masami Kitagawa, Eri Inami, Masato Yoshihara, Kazumasa Mogi, Yukari Nagao, Satoshi Tamauchi, Nobuhisa Yoshikawa, Kimihiro Nishino, Eiko Yamamoto, Kaoru Niimi, Hiroaki Kajiyama   +14 more
wiley   +1 more source

Ectopic non-gestational pure choriocarcinoma of the urinary bladder in a young nulliparous female: A diagnostic challenge

Indian Journal of Medical and Paediatric Oncology, 2020
Choriocarcinoma can occur at ectopic extragenital locations such as lungs, mediastinum, retroperitoneum, and even in the brain (nongestational choriocarcinoma).
Rahul Mannan, Sonam Sharma, Saloni Goyal, Tejinder Singh Bhasin   +3 more
doaj   +1 more source

Maternal Nutritional Status Governs Fetal Development by Modulating Imprinting Gene GAB1‐Mediated Trophoblast Differentiation in the Placenta

Cell Proliferation, Volume 58, Issue 12, December 2025.
Maternal nutrient restriction disrupts placental homeostasis via GAB1 dysregulation—involving both transcriptional downregulation and autophagy‐dependent protein degradation. These molecular alterations inhibit MAPK signalling‐mediated trophoblast fusion, leading to structural and functional deficits in the maternal–fetal exchange interface.
Mingming Fan, Hongyu Wu, Yuan Xie, Ming Liu, Xin Yu, Feiyang Wang, Zhenyu Xiao, Hongmei Wang, Xuan Shao, Yan‐Ling Wang   +9 more
wiley   +1 more source

Gestational trophoblastic neoplasia presenting as an interstitial ectopic pregnancy

Gynecologic Oncology Reports, 2021
Gestational trophoblastic disease (GTD) is a group of benign and malignant tumors that develop from placental tissue and includes hydatidiform moles and gestational trophoblastic neoplasia (GTN).
C. Toal, A.A. Garrett, S. Kostadinov, M. Boisen   +3 more
doaj   +1 more source

Germ cell and other tumors in individuals with differences in sex development

CA: A Cancer Journal for Clinicians, Volume 75, Issue 6, Page 587-601, November/December 2025.
Abstract Approximately one in 3500 to one in 5100 live‐born infants have atypical external genital development, known as differences in sex development (DSD). In 2005, an expert consensus conference thoroughly reviewed aspects of health care for individuals with DSD.
Selma Feldman Witchel, Miguel Reyes‐Múgica   +1 more
wiley   +1 more source

MicroRNA-34a is a tumor suppressor in choriocarcinoma via regulation of Delta-like1 [PDF]

, 2013
Background: Choriocarcinoma is a gestational trophoblastic tumor which causes high mortality if left untreated. MicroRNAs (miRNAs) are small non protein-coding RNAs which inhibit target gene expression.
Chiu, PCN, Lam, KKW, Lee, CL, Leung, CON, Pang, RTK, Ye, TM, Yeung, WSB   +6 more
core   +2 more sources

Non-gestational choriocarcinoma of ovary: Clinico-morphological features and diagnostic value of DNA polymorphism study

Human Pathology Reports, 2022
It is generally accepted that choriocarcinoma is a trophoblastic tumor of gestational origin during the reproductive period, but this neoplasm can rarely occur after menopause or be non-gestational making diagnosis a real challenge.
Alina Magnaeva, Aleksandra Asaturova, Anna Tregubova, Irina Matsneva, Alina Solopova   +4 more
doaj   +1 more source