Results 81 to 90 of about 7,058 (215)

AMHR2 mutation in persistent Müllerian duct syndrome: A case of transverse testicular ectopia

UroPrecision, Volume 4, Issue 1, Page 64-68, March 2026.
Abstract Backgroud Persistent Müllerian duct syndrome (PMDS) is a rare condition characterized by the persistence of Müllerian duct structures in genotypic and phenotypic males. Case Presentation We present the case of a 4‐month‐old male with PMDS who presented with transverse testicular ectopia. The patient underwent diagnostic laparoscopic orchiopexy
Hangcheng Fu, Weijing Huang, Jeffrey T. White   +2 more
wiley   +1 more source

HRS Degradation‐Induced Nicotinamide Deficiency in Placental Extracellular Vesicles Triggers Preeclampsia by Disrupting Maternal‐Fetal Immune Homeostasis

Advanced Science, Volume 13, Issue 11, 23 February 2026.
This study shows that lower NAM levels in PE‐derived pEVs correlate with disease severity. NAM‐deficient pEVs reduce Th1 and Th17 inhibition, leading to PE‐like symptoms. NAM in pEVs inhibits Th1 via SIRT1 and Th17 via macrophages. Reduced NAM in PE‐EVs is due to decreased HRS expression in trophoblasts, resulting from elevated HSP27.
Haiyi Fei, Yuhan Lin, Xiu Liu, Xiaohong Zhu, Xiaowen Lu, Zhan Shi, Fan Jia, Shiqian Xu, Ling Fang, Lingling Jiang, Songying Zhang   +10 more
wiley   +1 more source

A Novel Human Cellular System for Studying Normal Aging and for Anti‐Aging Discovery

Aging Cell, Volume 25, Issue 2, February 2026.
This study introduces a human cellular aging model using placental trophoblasts (hTSC‐STBs) that mimics key aging features like senescence and genomic instability. It aligns with human tissue aging and responds to anti‐aging treatments, offering a scalable platform to screen potential therapies and bridge lab findings to clinical applications ...
Zhen Feng, Cheuk Shuen Li, Haifeng Fu, Wenxin Jiang, Weiyu Zhang, Yingzhang Huang, Yunying Huang, Timothy Theodore Ka Ki Tam, Yang Li, Fang Liu, Liming Lu, Yin Lau Lee, William Shu Biu Yeung, Gordon Dougan, Pentao Liu   +14 more
wiley   +1 more source

Gestational choriocarcinoma with renal and pulmonary metastases lacking a primary uterine origin

Taiwanese Journal of Obstetrics & Gynecology, 2016
Objective: We describe a case of gestational choriocarcinoma metastasized to the kidney and lung, which presented initially as refractory hematuria after a term pregnancy 5 years earlier. Case Report: A 35-year-old woman, G2P1, with a previous history of
Hao-Ming Li, Wen-Chien Hou, Yu-Ju Lai, Chien-Chang Kao, Tai-Kuang Chao, Mu-Hsien Yu, Her-Young Su   +6 more
doaj   +1 more source

Pure ovarian choriocarcinoma: report of two cases

Journal of Research in Medical Sciences, 2009
<ul><li>Pure primary ovarian choriocarcinoma is an extremely rare condition of gestational or nongestational origin. The possibility of gestational origin can be suspected by the presence of a corpus luteum of pregnancy but definite diagnosis
Narges Izadi-Mood, Nasrin Samadi, Parvaneh Rahimi-Moghaddam, Soheila Sarmadi   +3 more
doaj  

Hemoptysis as primary manifestation in three women with choriocarcinoma with pulmonary metastasis: a case series

Journal of Medical Case Reports, 2017
Background Gestational choriocarcinoma is the most common gestational trophoblastic neoplasia; it is often secondary to hydatidiform mole, as well as to abortion, ectopic pregnancy, premature delivery, or term delivery. Approximately 60% of patients with
Wenping Zhang, Bao Liu, Jizhen Wu, Beibei Sun   +3 more
doaj   +1 more source

Choriocarcinoma with Uterine Rupture and Shock: A Rare Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2015
Choriocarcinoma is a rare neoplasm and a malignant form of gestational trophoblastic disease. Choriocarcinoma is frequently preceded by a complete mole, ectopic pregnancy, nonmolar intrauterine abortion, and uncommonly by a partial mole.
Manika Agarwal, Ritesh Kumar, Jupirika Pyrbot, A.S. Singh   +3 more
doaj   +1 more source

Identification and characterisation of NANOG+/OCT-4high/SOX2+ doxorubicin-resistant stem-like cells from transformed trophoblastic cell lines [PDF]

, 2018
Treatment of gestational trophoblastic diseases (GTD) involves surgery, radiotherapy and chemotherapy. Although, these therapeutic approaches are highly successful, drug resistance and toxicity remain a concern for high risk patients.
Aplin, Audus, Bajpai, Bellet, Berkowitz, Clarke, Fisher, Fowden, Frank, Gey, Heeschen, Huppertz, Johnson, Kwon, Lala, Lenz, Loke, Machado, Markovic, Qin, Rao, Rofstad, Seckl, Sessa, Taichman, Tang, Tsao, Weinberg, Yu, Yuan   +29 more
core   +2 more sources

Regulation of stanniocalcin-1 secretion by BeWo cells and first trimester human placental tissue from normal pregnancies and those at increased risk of developing preeclampsia. [PDF]

, 2020
Stanniocalcin-1 (STC-1) is a multi-functional glycosylated peptide present in the plasma of healthy women postpartum and increased further in pregnancies complicated by preeclampsia. Although the STC-1 gene is expressed by the placenta what regulates its
Asma Khalil, Baskaran Thilaganathan, Guy S. Whitley, Joan Embola, Judith E. Cartwright, Julia Bercher, Kim LC, Ma X, Naila Abid, Salnikow K, Sandra V. Ashton, Trindade DM, Wallace AE, Zoe Tryfonos   +13 more
core   +1 more source

Maternal obesity during pregnancy disrupts iron homeostasis and promotes fetal hypoxia in the mouse

The Journal of Physiology, Volume 604, Issue 1, Page 566-581, 1 January 2026.
Abstract figure legend Maternal obesity induces systemic inflammation and high insulin and leptin levels, potentially promoting hepcidin release into circulation and thus iron sequestration in specific tissue compartments. This results in low iron availability in the mother with potential detrimental effects on the fetus, including hypoxia.
Adriana Córdova‐Casanova, Isabella Inzani, Antonia Hufnagel, Dino A Giussani, Denise S. Fernandez‐Twinn, Susan E Ozanne   +5 more
wiley   +1 more source