Term delivery choriocarcinoma patient with brain and lung metastases successfully treated by etoposide, methotrexate, actomycin D, cyclophosphamide and vincristine (EMA-CO) chemotherapy. [PDF]
, 2005 It is well known that antecedent term delivery and metastasis to sites other than the lungs and vagina are high risk factors for patients with gestational trophoblastic neoplasia.
Hiramatsu, Yuji +4 more
core +1 more source
Rare Tumors, 2013 Primary choriocarcinoma of the ovary is rare. Furthermore, this tumor can arise from gestational tissue or pure germ cells of the ovary, with the latter resulting in non-gestational choriocarcinoma.
Fernando Nalesso +6 more
doaj +1 more source
AMHR2 mutation in persistent Müllerian duct syndrome: A case of transverse testicular ectopia
UroPrecision, EarlyView.Abstract Backgroud Persistent Müllerian duct syndrome (PMDS) is a rare condition characterized by the persistence of Müllerian duct structures in genotypic and phenotypic males. Case Presentation We present the case of a 4‐month‐old male with PMDS who presented with transverse testicular ectopia. The patient underwent diagnostic laparoscopic orchiopexy
Hangcheng Fu +2 more
wiley +1 more source
Gynecologic Oncology Reports, 2020 Background: Non-gestational choriocarcinomas represent a small subset of germ cell tumors. The majority of non-gestational choriocarcinomas arise from the gynecologic tract. In rare cases, they can originate from other sites, and very few such cases have
Evan Schrader +4 more
doaj +1 more source
Lentivirus-mediated RNA interference targeting the H19 gene inhibits cell proliferation and apoptosis in human choriocarcinoma cell line JAR [PDF]
, 2013 BACKGROUND: H19 is a paternally imprinted gene that has been shown to be highly expressed in the trophoblast tissue. Results from previous studies have initiated a debate as to whether noncoding RNA H19 acts as a tumor suppressor or as a tumor promotor ...
Dan Zhao +11 more
core +1 more source
A Novel Human Cellular System for Studying Normal Aging and for Anti‐Aging Discovery
Aging Cell, Volume 25, Issue 2, February 2026.This study introduces a human cellular aging model using placental trophoblasts (hTSC‐STBs) that mimics key aging features like senescence and genomic instability. It aligns with human tissue aging and responds to anti‐aging treatments, offering a scalable platform to screen potential therapies and bridge lab findings to clinical applications ...
Zhen Feng +14 more
wiley +1 more source
\ud Case Report: Unsuspected Uterine Choriocarcinoma with Lung Metastasis\ud [PDF]
, 2010 Choriocarcinoma is a rare form of cancer which commonly occurs in women of reproductive age, rarely in post-menopausal women and in women under 20 years of age.
Faustine, Lucas +8 more
core
Identification and characterisation of NANOG+/OCT-4high/SOX2+ doxorubicin-resistant stem-like cells from transformed trophoblastic cell lines [PDF]
, 2018 Treatment of gestational trophoblastic diseases (GTD) involves surgery, radiotherapy and chemotherapy. Although, these therapeutic approaches are highly successful, drug resistance and toxicity remain a concern for high risk patients.
Aplin +29 more
core +2 more sources
Cureus, 2021 Non-gestational choriocarcinoma of the ovary is a very rare neoplasm. It carries a worse prognosis as compared to gestational choriocarcinoma (GCC). Here, we report a case of non-gestational ovarian choriocarcinoma.
Abdul Sattar Anjum +4 more
semanticscholar +1 more source
Human placental cytotrophoblasts produce the immunosuppressive cytokine interleukin 10. [PDF]
, 1996 The mechanism by which the mammalian mother accepts the implanting fetus as an allograft remains unexplained, but is likely to be the result of a combination of factors.
Abrams, JS +5 more
core +1 more source