Results 51 to 60 of about 240,583 (210)

Chemotherapy resistance and risk stratification in gestational trophoblastic neoplasia: A systematic review and network meta‐analysis

open access: yesActa Obstetricia et Gynecologica Scandinavica, EarlyView.
Higher pretreatment β‐hCG, greater tumor burden, higher FIGO stage/score, and choriocarcinoma were associated with higher chemoresistance risk in gestational trophoblastic neoplasia. In exploratory network analyses, etoposide‐containing regimens showed lower predicted chemoresistance.
Ying‐Ying Xue   +7 more
wiley   +1 more source

Circulating miR‐342‐3p as a biomarker for diagnosing gestational diabetes mellitus and predicting adverse perinatal outcomes: A retrospective cohort study

open access: yesJournal of Diabetes Investigation, EarlyView.
ABSTRACT Aims This study evaluated the clinical utility of circulating miR‐342‐3p for diagnosing gestational diabetes mellitus (GDM) and predicting adverse perinatal outcomes (APOs). Methods A retrospective cohort of 261 GDM women (the GDM group) and 261 propensity score‐matched healthy controls (the Normal group) was analyzed.
Kangjun Yu, Sanqiang Niu, Hai Liang
wiley   +1 more source

Gestational Trophoblastic Disease

open access: yes, 2019
The diagnosis of gestational trophoblastic disease has witnessed revolutionary changes with improved availability of immunohistochemistry and genotyping as valuable adjuncts.
Wang, RW, Cheung, ANY
core   +1 more source

Periodontitis and Adverse Pregnancy Outcomes: Mechanistic Evidence

open access: yesJournal of Periodontal Research, EarlyView.
This narrative review aims to describe mechanisms linking periodontal diseases in pregnancy with adverse pregnancy outcomes. ABSTRACT Periodontal diseases, including both gingivitis and periodontitis, occur commonly among pregnant individuals. Both gingivitis and periodontitis are associated with adverse pregnancy outcomes (APOs) such as early ...
Gregory C. Valentine   +4 more
wiley   +1 more source

Leptin–cholesterol crosstalk in pregnancy: Mechanistic implications for placental function and cardiometabolic programming

open access: yesExperimental Physiology, EarlyView.
Abstract Pregnancy requires the coordinated maternal reorganization of lipid and endocrine pathways to sustain fetal growth and anticipate neonatal nutrition. Leptin, produced by adipose tissue and the placenta, acts as an integrative signal linking maternal energy status with trophoblast function and vascular adaptation, while cholesterol provides ...
Julio Flores   +4 more
wiley   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor   +4 more
wiley   +1 more source

High risk gestational trophoblastic diseases: Diagnosis and primary management with EMACO chemotherapy [PDF]

open access: yes, 2015
Gestational trophoblastic disease (GTD) is characterized by abnormal proliferation of pregnancy associated trophoblastic tissue with malignant potential.
Kadam R. Priyanka, Dave S. Pariseema
core   +1 more source

Gestational Trophoblastic Disease and Gestational Trophoblastic Neoplasm - An Experience at Tertiary Care Hospital

open access: yesANNALS OF ABBASI SHAHEED HOSPITAL AND KARACHI MEDICAL & DENTAL COLLEGE, 2018
Objective: To determine the frequency of gestational trophoblastic diseases and gestational  tropho-  blastic neoplasm, its risk factors and prognosis. Methods: This was a descriptive,  cross-sectional  study  conducted  at  Civil  Hospital,  Karachi  from  March 2015 to September 2015.
Shakira Perveen   +2 more
openaire   +2 more sources

Ascending infection of Gardnerella spp. and compartmentalized inflammatory response in fetal–maternal interface organ‐on‐chip model

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend The fetal–maternal interface organ‐on‐chip was used to investigate the ascending infection of Gardnerella spp. across the decidua (DEC), chorion trophoblast (CTC), amnion mesenchymal (AMC) and amnion epithelial (AEC) compartments over 48 h.
Mariana de Castro Silva   +7 more
wiley   +1 more source

p21-activated kinase-1 promotes aggressive phenotype, cell proliferation, and invasion in gestational trophoblastic disease

open access: yes, 2010
Gestational trophoblastic disease (GTD) includes hydatidiform mole (HM), which can develop persistent gestational trophoblastic neoplasia requiring chemotherapy; choriocarcinoma, which is a frankly malignant tumor; placental site trophoblastic tumor; and
Chan, DCW   +7 more
core   +1 more source

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