Results 11 to 20 of about 30,876 (143)

G9a an Epigenetic Therapeutic Strategy for Neurodegenerative Conditions: From Target Discovery to Clinical Trials. [PDF]

Med Res Rev
ABSTRACT This review provides a comprehensive overview of the role of G9a/EHMT2, focusing on its structure and exploring the impact of its pharmacological and/or gene inhibition in various neurological diseases. In addition, we delve into the advancements in the design and synthesis of G9a/EHMT2 inhibitors, which hold promise not only as a treatment ...
Bellver-Sanchis A, Ribalta-Vilella M, Irisarri A, Gehlot P, Choudhary BS, Jana A, Vyas VK, Banerjee DR, Pallàs M, Guerrero A, Griñán-Ferré C.   +10 more
europepmc   +2 more sources

Robust identification of conventional and leukemic nonnodal mantle cell lymphomas using epigenetic biomarkers. [PDF]

Hemasphere
HemaSphere, Volume 8, Issue 1, January 2024.
Bühler MM, Kulis M, Duran-Ferrer M, López C, Clot G, Nadeu F, Romo M, Giné E, López-Guillermo A, Beà S, Campo E, Martín-Subero JI.   +11 more
europepmc   +2 more sources

Testicular large B-cell lymphoma is genetically similar to PCNSL and distinct from nodal DLBCL. [PDF]

Hemasphere
Abstract Testicular large B‐cell lymphoma (TLBCL) is an infrequent and aggressive lymphoma arising in an immune‐privileged site and has recently been recognized as a distinct entity from diffuse large B‐cell lymphoma (DLBCL). We describe the genetic features of TLBCL and compare them with published series of nodal DLBCL and primary large B‐cell ...
Rivas-Delgado A, López C, Clot G, Nadeu F, Grau M, Frigola G, Bosch-Schips J, Radke J, Ishaque N, Alcoceba M, Tapia G, Luizaga L, Barcena C, Kelleher N, Villamor N, Baumann T, Muntañola A, Sancho-Cia JM, García-Sancho AM, Gonzalez-Barca E, Matutes E, Brito JA, Karube K, Salaverria I, Enjuanes A, Wiemann S, Heppner FL, Siebert R, Climent F, Campo E, Giné E, López-Guillermo A, Beà S.   +32 more
europepmc   +2 more sources

Neural signatures of memory gain through active exploration in an oculomotor‐auditory learning task

Psychophysiology, Volume 60, Issue 10, October 2023., 2023
Abstract Active engagement improves learning and memory, and self‐ versus externally generated stimuli are processed differently: perceptual intensity and neural responses are attenuated. Whether the attenuation is linked to memory formation remains unclear. This study investigates whether active oculomotor control over auditory stimuli—controlling for
Stefanie Sturm, Jordi Costa‐Faidella, Iria SanMiguel   +2 more
wiley   +1 more source

Protecting great apes from disease: Compliance with measures to reduce anthroponotic disease transmission

People and Nature, Volume 4, Issue 5, Page 1387-1400, October 2022., 2022
Abstract The emergence of infectious diseases, such as COVID‐19, impacts livelihood strategies and conservation tools reliant on human‐wildlife interactions, such as wildlife‐based tourism and research. This is particularly relevant to great ape conservation, as humans and great apes are susceptible to being infected by similar pathogens.
Ana Nuno, Chloe Chesney, Maia Wellbelove, Elena Bersacola, Gladys Kalema‐Zikusoka, Fabian Leendertz, Amanda D. Webber, Kimberley J. Hockings   +7 more
wiley   +1 more source

Contributions of the international plant science community to the fight against human infectious diseases – part 1: epidemic and pandemic diseases

Plant Biotechnology Journal, Volume 19, Issue 10, Page 1901-1920, October 2021., 2021
Summary Infectious diseases, also known as transmissible or communicable diseases, are caused by pathogens or parasites that spread in communities by direct contact with infected individuals or contaminated materials, through droplets and aerosols, or via vectors such as insects.
Maria Lobato Gómez, Xin Huang, Derry Alvarez, Wenshu He, Can Baysal, Changfu Zhu, Victoria Armario‐Najera, Amaya Blanco Perera, Pedro Cerda Bennasser, Andera Saba‐Mayoral, Guillermo Sobrino‐Mengual, Ashwin Vargheese, Rita Abranches, Isabel Alexandra Abreu, Shanmugaraj Balamurugan, Ralph Bock, Johannes.F. Buyel, Nicolau B. da Cunha, Henry Daniell, Roland Faller, André Folgado, Iyappan Gowtham, Suvi T. Häkkinen, Shashi Kumar, Sathish Kumar Ramalingam, Cristiano Lacorte, George P. Lomonossoff, Ines M. Luís, Julian K.‐C. Ma, Karen. A. McDonald, Andre Murad, Somen Nandi, Barry O’Keefe, Kirsi‐Marja Oksman‐Caldentey, Subramanian Parthiban, Mathew J. Paul, Daniel Ponndorf, Elibio Rech, Julio C. M. Rodrigues, Stephanie Ruf, Stefan Schillberg, Jennifer Schwestka, Priya S. Shah, Rahul Singh, Eva Stoger, Richard M. Twyman, Inchakalody P. Varghese, Giovanni R. Vianna, Gina Webster, Ruud H. P. Wilbers, Teresa Capell, Paul Christou   +51 more
wiley   +1 more source

Contributions of the international plant science community to the fight against infectious diseases in humans—part 2: Affordable drugs in edible plants for endemic and re‐emerging diseases

Plant Biotechnology Journal, Volume 19, Issue 10, Page 1921-1936, October 2021., 2021
Summary The fight against infectious diseases often focuses on epidemics and pandemics, which demand urgent resources and command attention from the health authorities and media. However, the vast majority of deaths caused by infectious diseases occur in endemic zones, particularly in developing countries, placing a disproportionate burden on ...
Wenshu He, Can Baysal, Maria Lobato Gómez, Xin Huang, Derry Alvarez, Changfu Zhu, Victoria Armario‐Najera, Aamaya Blanco Perera, Pedro Cerda Bennaser, Andrea Saba‐Mayoral, Guillermo Sobrino‐Mengual, Ashwin Vargheese, Rita Abranches, Isabel Alexandra Abreu, Shanmugaraj Balamurugan, Ralph Bock, Johannes F. Buyel, Nicolau B. da Cunha, Henry Daniell, Roland Faller, André Folgado, Iyappan Gowtham, Suvi T. Häkkinen, Shashi Kumar, Ramalingam Sathish Kumar, Cristiano Lacorte, George P. Lomonossoff, Ines M. Luís, Julian K.‐C. Ma, Karen A. McDonald, Andre Murad, Somen Nandi, Barry O’Keef, Subramanian Parthiban, Mathew J. Paul, Daniel Ponndorf, Elibio Rech, Julio C.M. Rodrigues, Stephanie Ruf, Stefan Schillberg, Jennifer Schwestka, Priya S. Shah, Rahul Singh, Eva Stoger, Richard M. Twyman, Inchakalody P. Varghese, Giovanni R. Vianna, Gina Webster, Ruud H. P. Wilbers, Paul Christou, Kirsi‐Marja Oksman‐Caldentey, Teresa Capell   +51 more
wiley   +1 more source

Single human oocyte transcriptome analysis reveals distinct maturation stage‐dependent pathways impacted by age

Aging Cell, Volume 20, Issue 5, May 2021., 2021
Here we used single‐oocyte RNA‐Seq to study the transcriptome changes occurring during human oocyte aging. We sampled Germinal Vesicle (GV) stage oocytes from women of age 18–43 and analyzed them directly (GV) or after in vitro maturation (IVM‐MII). We observed that age has a bigger impact on the IVM‐MII transcriptome.
Sílvia Llonch, Montserrat Barragán, Paula Nieto, Anna Mallol, Marc Elosua‐Bayes, Patricia Lorden, Sara Ruiz, Filippo Zambelli, Holger Heyn, Rita Vassena, Bernhard Payer   +10 more
wiley   +1 more source

Genome‐wide postnatal changes in immunity following fetal inflammatory response

The FEBS Journal, Volume 288, Issue 7, Page 2311-2331, April 2021., 2021
The exposure to a fetal inflammatory response (FIR) is often followed by a postnatal systemic inflammation, increasing the risk of perinatal brain injury. We profiled the transcriptome and proteome in neonatal dried blood spots from extremely preterm newborns (< 28 weeks of gestation), affected and unaffected by FIR.
Daniel Costa, Núria Bonet, Amanda Solé, José Manuel González de Aledo‐Castillo, Eduard Sabidó, Ferran Casals, Carlota Rovira, Alfons Nadal, Jose Luis Marin, Teresa Cobo, Robert Castelo   +10 more
wiley   +1 more source

A co‐development approach to conservation leads to informed habitat design and rapid establishment of amphibian communities

Ecological Solutions and Evidence, Volume 2, Issue 1, January–March 2021., 2021
Stakeholders came together to manage an evidence–based project to restore and create ponds for amphibians. After four years the intervention ponds had higher mean amphibian species richness than long–established local ponds. Abstract 1. Effective wildlife restoration is a critical requirement of many conservation actions.
David O'Brien, Jeanette E. Hall, Alexandre Miró, Katie O'Brien, Robert Jehle   +4 more
wiley   +1 more source