Results 71 to 80 of about 121,293 (247)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Exploring Annotation of Head Gesture Forms in Spontaneous Human Interaction [PDF]
, 2013 Kousidis S, Malisz Z, Wagner P, Schlangen D. Exploring Annotation of Head Gesture Forms in Spontaneous Human Interaction.
Wagner, Petra ; https://orcid.org/ +3 more
core
Gesture Processing as Grounded Motor Cognition - Towards a Computational Model [PDF]
, 2012 Sadeghipour A, Kopp S. Gesture Processing as Grounded Motor Cognition - Towards a Computational Model. In: Rahbar-Shamskar A, ed. 4th International Conference of Cognitive Science (ICCS 2011). Procedia - Social and Behavioral Sciences. Vol 32.
Kopp, Stefan ; https://orcid.org/ +2 more
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Il gesto assoluto. Duchamp, l’opera d’arte e il linguaggio
Lebenswelt: Aesthetics and Philosophy of Experience, 2019 The Marcel Duchamp absolute gesture is such a gesture that inaugurates an escape movement from any Symbolic Order (another name of this movement is the Deleuzian «becoming-animal»); a gesture that, obviously, Duchamp does not stop play out, because each ...
Felice Cimatti
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
A spreading-activation model of the semantic coordination of speech and gesture [PDF]
, 2013 Kopp S, Bergmann K, Kahl S. A spreading-activation model of the semantic coordination of speech and gesture. In: Proceedings of the 35th Annual Meeting of the Cognitive Science Society (CogSci 2013). Austin, TX: Cognitive Science Society; 2013: 823-828.
Kopp, Stefan ; https://orcid.org/ +2 more
core
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source