Results 201 to 210 of about 520,090 (317)

GFP-NIC96 [PDF]

, 2020
openaire   +1 more source

Ultrasound‐Actuated Gene Editing in Human Kidney Organoids

Advanced Science, EarlyView.
Peptide‐stabilized nanoemulsions enable spatially controlled, ultrasound‐triggered delivery of gene‐editing proteins deep within human kidney organoid tissues. Focused acoustic pulses drive droplet vaporization, propelling cargo into target renal cells while preserving native tissue microarchitecture. This non‐viral platform improves both the depth and
Michael A. Miller, Nicole Vo, Utkarsh, Ivan Sokirniy, Justin Pritchard, Benjamin S. Freedman, Scott H. Medina   +6 more
wiley   +1 more source

Anticodon-engineered tRNAs restore full-length MeCP2 expression and function in Rett syndrome nonsense mutations. [PDF]

Front Neurol
Fara E, Pezzini S, Arpaia G, Frasca A, Porter JJ, Lueck JD, Landsberger N.   +6 more
europepmc   +1 more source

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source

Nonsense mutations can increase mRNA levels

Biology Open
Precious O. Owuamalam, Md. Nazmul Hossain, Saverio Brogna   +2 more
doaj   +1 more source

Dissecting the propensity of RIM1 subdomains to form phase condensates. [PDF]

Sci Rep
Kersten L, Galkov M, Nemcova P, Mostafa AHD, Quatraccioni A, Dietrich D, Schoch S.   +6 more
europepmc   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

hSpindly dynamics modulate spindle assembly checkpoint signaling, promoting resistance to mitotic inhibitors. [PDF]

iScience
Mora-Santos M, Herrero-Ruiz J, Fennema-Galparsoro D, Belmonte-Fernández A, Ferrandiz N, Romero F.   +5 more
europepmc   +1 more source

Redox‐Dependent Chaperoning of GBF1 Condensates Regulates Seed Germination in Arabidopsis

Advanced Science, EarlyView.
In dormant seeds (low ROS), GBF1 forms liquid condensates to repress the germination gene CathB3, and the chaperone GIP1 maintains condensate liquidity and repressive activity. Upon imbibition (high ROS), ROS oxidize GIP1 during germination, impairing its chaperone function.
Yunying Wang, Xiaofeng Fang
wiley   +1 more source

Severe Restriction of Glucose Import Enhances Recombinant Protein Production in Escherichia coli. [PDF]

Biotechnol J
Fragoso-Jiménez JC, Sigala JC, Delvigne F, Martínez A, Lara AR, Gosset G.   +5 more
europepmc   +1 more source