Results 211 to 220 of about 701,605 (308)

EYA4 promotes cellular senescence by enhancing P21 transcription through interaction with SIX2. [PDF]

Adv Biotechnol (Singap)
Li X, Mao P, Chen D, Li L, Fang H, Huang J, Liu H.   +6 more
europepmc   +1 more source

BLADE‐ON‐PETIOLE Genes Enable Genetic Bottleneck Mitigation Through Cross‐Species Repurposing of Floral Persistence Traits

Advanced Science, EarlyView.
This study shows that BLADE‐ON‐PETIOLE (BOP) proteins regulate floral abscission and senescence in tomato by interacting with TFAM1 to form transcriptional condensates controlling the ARABIDOPSIS THALIANA HOMEOBOX GENE 1 (ATH1)‐mediated abscission pathway.
Nan Xiao, Qianwen Lyu, Tinghao Zhang, Yupan Zou, Yue Xie, Dandan Yang, Cao Xu, Xiaozhen Huang   +7 more
wiley   +1 more source

Increased Bacterial Load per Neutrophil Reduces Intracellular Killing Capacity. [PDF]

J Innate Immun
Duebel LV, Dekker SO, Bongers SH, van Aalst C, Mulder E, Hietbrink F, Koenderman L, Vrisekoop N.   +7 more
europepmc   +1 more source

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

Tomato Brown Rugose Fruit Virus Evades Tm-2²-Mediated Resistance by Avoiding the Induction of Tm-2² Self-Association. [PDF]

Mol Plant Pathol
Ma HY, Liu YJ, Huan XX, Liu SY, Mu XQ, Zhang LM, Bao ZL, Tian YP, Yan ZY, Li XD.   +9 more
europepmc   +1 more source

ECM‐Stiffness Mediated Persistent Fibroblast Activation Requires Integrin and Formin Dependent Chromatin Remodeling

Advanced Science, EarlyView.
Prolonged exposure to stiff extracellular matrix drives cancer‐associated fibroblasts into a persistently activated myofibroblast state. Two parallel pathways are identified: β1 integrin activation smoothens the nuclear lamina to reduce lamin–chromatin contacts, while the formin mDia2 regulates nuclear actin to alter chromatin organization.
Swathi Packirisamy, Oscar André, Zhimeng Fan, Pontus Nordenfelt, Vinay S Swaminathan   +4 more
wiley   +1 more source

Arp2/3 involvement in intercellular bridge membrane fluctuations and constriction during neural stem cell divisions. [PDF]

iScience
LaFoya B, Ortman MN, Fries A, Nolen BJ, Prehoda KE.   +4 more
europepmc   +1 more source

A Functionally Conserved Enhancer is Critical for PGC1A Expression and Thermogenesis in Brown Fat

Advanced Science, EarlyView.
An evolutionarily conserved enhancer controls PGC1A expression and thermogenic activation in brown adipose tissue. Integrative multi‐omics analyses identify two BAT‐specific enhancers, with PGC1A‐En1 functioning as the dominant regulatory element that maintains thermogenic capacity across species.
Duo Su, Haosen Yang, Xiaokai Li, Tingting Jiang, Siyuan Zhan, Tao Zhong, Jiazhong Guo, Yan Wang, Li Li, Hongping Zhang, Linjie Wang   +10 more
wiley   +1 more source

The lipid flippase MoNeo1 mediates vesicle trafficking and pathogenicity in Magnaporthe oryzae. [PDF]

Stress Biol
Cai Y, Huang X, Nie Y, Luan Y, Aarti A, Gong Q, Sun P, Abubakar YS, Wang B, Wang A, Li G, Lin L, Zheng W.   +12 more
europepmc   +1 more source

GFP-expression in subplate cells in the Edg2-GFP and CTGF-GFP mouse

, 2016
Hoerder-Suabedissen, A, Kousha, O, Garcia-Moreno, F, Molnar, Z   +3 more
openaire   +1 more source