Results 141 to 150 of about 147,929 (284)

Physiologically based pharmacokinetic modeling and simulation of topiramate in populations with renal and hepatic impairment and considerations for drug–drug interactions

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 510-522, March 2025.
Abstract Topiramate (TPM) is a broad‐spectrum antiepileptic drug (AED) commonly prescribed for approved and off‐label uses. Routine monitoring is suggested for clinical usage of TPM in special population due to its broad side effect profile. Therefore, it is crucial to further explore its pharmacokinetic characteristics.
Shuqing Chen   +6 more
wiley   +1 more source

Population Pharmacokinetics and Transfer of Gabapentin When Used as a Pain Adjunct for Cesarean Deliveries

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 551-560, March 2025.
ABSTRACT Enhanced Recovery After Surgery (ERAS) protocols for cesarean deliveries (CDs) utilize multimodal pain management strategies that often include gabapentin. While gabapentin is excreted in breast milk, its pharmacokinetics in immediately postpartum lactating women are not known. This observational pharmacokinetic study (NCT05099484) enrolled 21
Rebecca Silvola   +9 more
wiley   +1 more source

FP771IOHEXOL CLEARANCE IN CHILDREN WITH LOW GFR: COMPARISON OF 24 HOURS SINGLE-POINT GFR AND MULTIPLE-POINT GFR [PDF]

open access: yesNephrology Dialysis Transplantation, 2018
Camilla Tøndel   +7 more
openaire   +1 more source

Modeling of Disease Progression of Type 2 Diabetes Using Real‐World Data: Quantifying Competing Risks of Morbidity and Mortality

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 606-615, March 2025.
ABSTRACT Type 2 diabetes (T2D) is a progressive metabolic disorder that could be an underlying cause of long‐term complications that increase mortality. The assessment of the probability of such events could be essential for mortality risk management. This work aimed to establish a framework for risk predictions of macrovascular complications (MVC) and
Hanna Kunina   +2 more
wiley   +1 more source

Single‐cell‐based non‐invasive screening for fetal pathogenic microimbalances using maternal blood: comparison with invasive prenatal diagnosis

open access: yesUltrasound in Obstetrics &Gynecology, EarlyView.
ABSTRACT Objective Pathogenic or likely pathogenic copy‐number variants (p/lpCNVs) are a significant cause of perinatal morbidity and mortality. Current prenatal screening based on cell‐free DNA (cfDNA) fails to detect the majority of microimbalances (microdeletions/microduplications), leaving a significant residual risk of undetected chromosomal ...
T. Stampalija   +60 more
wiley   +1 more source

Late Antique Allāh: Ancestral Arabian Religion and the Monotheistic Zeitgeist

open access: yesArabian Archaeology and Epigraphy, EarlyView.
ABSTRACT This essay addresses the ongoing scholarly tension between the monotheistic interpretations of late pre‐Islamic Arabian religion, pioneered by G. Hawting and P. Crone, and the traditional accounts of rampant Arabian polytheism found in later Islamic literary sources.
Ahmad Al‐Jallad, Hythem Sidky
wiley   +1 more source

GFR [PDF]

open access: yes, 2019
openaire   +1 more source

Optimizing Prolonged (6 h) Normothermic Machine Perfusion of Donor Kidneys (PROPER Study)

open access: yesArtificial Organs, EarlyView.
Prolonged ex situ normothermic machine perfusion of donor kidneys up to 6 h is feasible, maintaining viability and histological integrity. Key protocol optimizations include fresh red blood cells, albumin supplementation, and urine recirculation—laying the groundwork for assessment and potential pretransplant interventions in future clinical trials ...
Asel S. Arykbaeva   +14 more
wiley   +1 more source

Plasma Adsorption Perfusion (BR‐350) Versus Open Albumin Dialysis (OPAL) for Hyperbilirubinemia in Hepatic Failure in Cirrhotic Patients

open access: yesArtificial Organs, EarlyView.
The therapy with PAP using BR‐350 resulted in a significant decrease of bilirubin concentrations. The median relative reduction of bilirubin was comparable between PAP and OPAL (47% vs. 40%, p = 0.29). The crossover comparison between the single session of PAP using BR‐350 and OPAL revealed similar relative reduction rates of bilirubin.
Justa Friebus‐Kardash   +8 more
wiley   +1 more source

Haematopoietic stem cell transplantation outcomes for teenage and young adult patients with acute leukaemia: A British Society of Blood and Marrow Transplantation and Cellular Therapy registry study

open access: yesBritish Journal of Haematology, EarlyView.
Summary Teenage and young adult (TYA) patients undergoing allogeneic stem cell transplant have distinct psychosocial needs, yet they are poorly represented in research and their outcomes are not well understood. This study uses prospectively collected data from the British Society of Blood and Marrow Transplantation and Cellular Therapy (BSBMTCT ...
Graham McIlroy   +15 more
wiley   +1 more source

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