Results 61 to 70 of about 338,732 (239)

Psychosocial Outcomes in Patients With Endocrine Tumor Syndromes: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction The combination of disease manifestations, the familial burden, and varying penetrance of endocrine tumor syndromes (ETSs) is unique. This review aimed to portray and summarize available data on psychosocial outcomes in patients with ETSs and explore gaps and opportunities for future research and care.
Daniël Zwerus, Floortje Strobbe, Annemarie A. Verrijn Stuart, Hanneke M. van Santen, Gerlof D. Valk, Sasja A. Schepers, Rachel S. van Leeuwaarde   +6 more
wiley   +1 more source

The Versatile Role of Peroxisome Proliferator-Activated Receptors in Immune-Mediated Intestinal Diseases

Cells
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that sense lipophilic molecules and act as transcription factors to regulate target genes.
Edit Posta, Istvan Fekete, Istvan Varkonyi, Eva Zold, Zsolt Barta   +4 more
doaj   +1 more source

Multi-site phosphorylation of the inhibitory guanine nucleotide regulatory protein Gi-2 occurs in intact rat hepatocytes [PDF]

Biochemical Journal, 1994
A phosphorylated form of alpha-Gi-2 (the alpha-subunit of Gi-2), immunoprecipitated from hepatocytes under basal conditions, migrated as a single species of pI approximately 5.7, the labelling of which increased approximately 2-fold in cells challenged with either vasopressin or phorbol 12-myristate 13-acetate (PMA); agents which activate protein ...
N J, Morris, M, Bushfield, B E, Lavan, M D, Houslay   +3 more
openaire   +2 more sources

Predicting Chronicity in Children and Adolescents With Newly Diagnosed Immune Thrombocytopenia at the Timepoint of Diagnosis Using Machine Learning‐Based Approaches

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives To identify predictors of chronic ITP (cITP) and to develop a model based on several machine learning (ML) methods to estimate the individual risk of chronicity at the timepoint of diagnosis. Methods We analyzed a longitudinal cohort of 944 children enrolled in the Intercontinental Cooperative immune thrombocytopenia (ITP) Study ...
Severin Kasser, Alice Bizeul, Meera Chitlur, Hugo Donato, Jelena Roganovic, Julia E. Vogt, Thomas Kühne   +6 more
wiley   +1 more source

FoxO6-mediated IL-1β induces hepatic insulin resistance and age-related inflammation via the TF/PAR2 pathway in aging and diabetic mice

Redox Biology, 2019
FoxO has been proposed to play a role in the promotion of insulin resistance, and inflammation. FoxO is a pro-inflammatory transcription factor that is a key mediator of generation of inflammatory cytokines such as IL-1β in the liver.
Dae Hyun Kim, Bonggi Lee, Jaewon Lee, Mi Eun Kim, Jun Sik Lee, Jae Heun Chung, Byung Pal Yu, H. Henry Dong, Hae Young Chung   +8 more
doaj   +1 more source

Gastrointestinal Manifestations of SARS-CoV-2: Transmission, Pathogenesis, Immunomodulation, Microflora Dysbiosis, and Clinical Implications

Viruses, 2023
The clinical manifestation of COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in the respiratory system of humans is widely recognized. There is increasing evidence suggesting that SARS-CoV-2 possesses the capability
Siva Sundara Kumar Durairajan, Abhay Kumar Singh, Udhaya Bharathy Saravanan, Mayurikaa Namachivayam, Moorthi Radhakrishnan, Jian-Dong Huang, Rahul Dhodapkar, Hongjie Zhang   +7 more
doaj   +1 more source

Restricted connectivity of cartesian products of some graphs [PDF]

, 2016
A vertex cut S of G is said to be a restricted vertex cut if NG(u) - S , ? for any vertex u of G. If G has a restricted vertex cut, then the minimum cardinality of them called the restricted connectivity of G and we denote the restricted connectivity of ...
北 顕弘
core   +1 more source

The global geometry of the moduli space of curves

, 2008
This is a survey written for the Proceedings of the AMS Summer Institute in Algebraic Geometry held in Seattle in 2005. Topics discussed in the survey include the ample and the effective cone of the moduli space of curves, Kodaira dimension, Slope ...
Farkas, Gavril
core   +2 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Which strain of the avian coronavirus vaccine will become the prevalent one in China next?

Frontiers in Veterinary Science, 2023
Infectious bronchitis virus (IBV) is a vital pathogen in poultry farms, which can induce respiratory, nephropathogenic, oviduct, proventriculus, and intestinal diseases.
Haizhu Li, Gengsong Liu, Qiaoyan Zhou, Hongchun Yang, Congcong Zhou, Weili Kong, Jieyu Su, Jieyu Su, Jieyu Su, Gonghe Li, Gonghe Li, Gonghe Li, Hongbin Si, Hongbin Si, Hongbin Si, Changbo Ou, Changbo Ou, Changbo Ou   +17 more
doaj   +1 more source