Results 61 to 70 of about 273,571 (270)

SARS-CoV-2 Gastrointestinal Infection Prolongs the Time to Recover From COVID-19

Frontiers in Medicine, 2021
Objectives: We previously reported that SARS-CoV-2 infects the gastrointestinal (GI) epithelium. In this study, we aimed to explore the impact of SARS-CoV-2 GI infection on clinical outcomes of COVID-19.Materials and Methods: For this retrospective ...
Zhijie Xu, Zhijie Xu, Zhijie Xu, Meiwen Tang, Meiwen Tang, Meiwen Tang, Ping Chen, Hongyu Cai, Fei Xiao, Fei Xiao, Fei Xiao   +10 more
doaj   +1 more source

Tail asymptotics for delay in a half-loaded GI/GI/2 queue with heavy-tailed job sizes [PDF]

Queueing Systems, 2015
We obtain asymptotic bounds for the tail distribution of steady-state waiting time in a two server queue where each server processes incoming jobs at a rate equal to the rate of their arrivals (that is, the half-loaded regime). The job sizes are taken to be regularly varying. When the incoming jobs have finite variance, there are basically two types of
Jose Blanchet, Karthyek Murthy
openaire   +3 more sources

Deletion of the GI-2 integrase and the wbkA flanking transposase improves the stability of Brucella melitensis Rev 1 vaccine [PDF]

Veterinary Research, 2013
Abstract Brucella melitensis Rev 1 is the best vaccine available for the prophylaxis of small ruminant brucellosis and, indirectly, for reducing human brucellosis. However, Rev 1 shows anomalously high rates of spontaneous dissociation from smooth (S) to rough (R) bacteria, the latter being inefficacious as vaccines.
Beatriz San-Román, María Jesús Grilló, Ignacio López-Goñi, María-Jesús de Miguel, Ignacio Moriyón, Marcos Mancilla, Marcos Mancilla, Ana Zabalza-Baranguá   +7 more
openaire   +7 more sources

Detection of a New Recombinant Rabbit Hemorrhagic Disease Virus 2 in China and Development of Virus-like Particle-Based Vaccine. [PDF]

Viruses
Rabbit hemorrhagic disease virus (RHDV) is a very virulent virus of the genus Lagovirus causing severe and fatal hepatitis in the European rabbit (Oryctolagus cuniculus). RHDV has two distinct genotypes: GI.1 (RHDV) and GI.2 (RHDV2). The first RHDV2/GI.2
Hu B, Dong W, Song Y, Fan Z, Cavadini P, Wang F.   +5 more
europepmc   +2 more sources

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

FEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga, Kazuki Harada, Takuya Yamauchi, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi   +6 more
wiley   +1 more source

The Versatile Role of Peroxisome Proliferator-Activated Receptors in Immune-Mediated Intestinal Diseases

Cells
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that sense lipophilic molecules and act as transcription factors to regulate target genes.
Edit Posta, Istvan Fekete, Istvan Varkonyi, Eva Zold, Zsolt Barta   +4 more
doaj   +1 more source

Which strain of the avian coronavirus vaccine will become the prevalent one in China next?

Frontiers in Veterinary Science, 2023
Infectious bronchitis virus (IBV) is a vital pathogen in poultry farms, which can induce respiratory, nephropathogenic, oviduct, proventriculus, and intestinal diseases.
Haizhu Li, Gengsong Liu, Qiaoyan Zhou, Hongchun Yang, Congcong Zhou, Weili Kong, Jieyu Su, Jieyu Su, Jieyu Su, Gonghe Li, Gonghe Li, Gonghe Li, Hongbin Si, Hongbin Si, Hongbin Si, Changbo Ou, Changbo Ou, Changbo Ou   +17 more
doaj   +1 more source

Multi-site phosphorylation of the inhibitory guanine nucleotide regulatory protein Gi-2 occurs in intact rat hepatocytes [PDF]

Biochemical Journal, 1994
A phosphorylated form of alpha-Gi-2 (the alpha-subunit of Gi-2), immunoprecipitated from hepatocytes under basal conditions, migrated as a single species of pI approximately 5.7, the labelling of which increased approximately 2-fold in cells challenged with either vasopressin or phorbol 12-myristate 13-acetate (PMA); agents which activate protein ...
Miles D. Houslay, M Bushfield, Nicholas J. Morris, B E Lavan   +3 more
openaire   +3 more sources

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source