Results 191 to 200 of about 483,563 (314)

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Correction: Gut microbiome is associated with stereotypic behavior of the giant panda (Ailuropoda melanoleuca). [PDF]

PLoS One
Hu A, Liu J, Chen P, Yang K, Xu F, Luo G, Zhang J, He M.   +7 more
europepmc   +1 more source

AN MHD MODEL FOR MAGNETAR GIANT FLARES

, 2014
Giant flares on soft gamma-ray repeaters that are thought to take place on magnetars release enormous energy in a short time interval. Their power can be explained by catastrophic instabilities occurring in the magnetic field configuration and the ...
Lin, J., Reeves, K. K., Zhang, Q. S., Zhang, L., Meng, Y., Yuan, F.   +5 more
core  

Voltage‐Driven Non‐Volatile Interconversion Between Giant Single‐Domain and Multidomain Magnetic States in a Multiferroic Heterostructure

Advanced Science, EarlyView.
Non‐volatile voltage control of magnetic configurations is achieved in a strain‐coupled multiferroic heterostructure. Voltage pulses reversibly interconvert giant single‐domain and multidomain magnetic states, which remain stable at zero applied voltage. ABSTRACT Voltage control of magnetic states in multiferroic heterostructures represents a promising
M. Ghidini, S. Valencia, A. Lesaine, R. Mansell, V. Farenkov, X. Moya, N. A. Stelmashenko, F. Maccherozzi, C. W. H. Barnes, F. Kronast, S. S. Dhesi, N. D. Mathur   +11 more
wiley   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Gut microbiome is associated with stereotypic behavior of the giant panda (Ailuropoda melanoleuca). [PDF]

PLoS One
Hu A, Liu J, Chen P, Yang K, Xu F, Luo G, Zhang J, He M.   +7 more
europepmc   +1 more source

On the Shoulders of Giants [PDF]

Journal of the Royal Society of Medicine, 1997
openaire   +2 more sources

F‐Type Pyocin Versus Phage λ Tail: Conserved Hub, Divergent Fibers

Advanced Science, EarlyView.
Near‐atomic cryo‐EM structures of a Gram‐negative F‐type pyocin reveal a conserved tail tip architecture shared with bacteriophage λ together with a previously unrecognized side‐fiber attachment mode. These findings provide new insight into tailocin assembly and host recognition and establish a structural framework for engineering precision ...
Zhiwei Gu, Yufan Xie, Lanxin Wang, Luyan Ma, Xiaofei Ge, Jiawei Wang   +5 more
wiley   +1 more source

Anomalous Enhancement in MXene‐Based Electrochemical Actuators: Pseudo‐Capacitance‐Induced Multi‐Charge Accumulation in Confined Space

Advanced Science, EarlyView.
We elucidate the electrochemical actuation mechanism of 2D material‐based electrodes within a MXene‐centered framework, linking atomic‐scale surface chemistry to macroscopic performance (see schematic). Mechanistically, the reduction of Ti─O─Ti sites in H2SO4 triggers the accumulation of hydrated ions at confined active sites, resulting in anomalous ...
Jiang Xu, Jipeng Feng, Bingqing Hu, Xude Li, Shifei Huang, Shanhai Ge, Guoxiu Wang   +6 more
wiley   +1 more source

Neuromorphic Devices and Computing for Sensing, Memory, and Control

Advanced Science, EarlyView.
This review introduces neuromorphic devices made from diverse materials. These devices mimic neuronal functions and architectures and, when integrated with artificial or biological computing, can form closed loops with neurons for pressure, optical, acoustic, and biochemical sensing and modulation.
Zhengguang Zhu, Nicholas Schaffer, Xiao Yang   +2 more
wiley   +1 more source