Results 91 to 100 of about 64,522 (303)

High frequency of CD95+/CD45RA− regulatory T cells defines an immunosuppressive profile associated with MDS progression

open access: yesBritish Journal of Haematology, EarlyView.
Summary Dynamic interactions between mutated haematopoietic cells and immune cells are key drivers of myelodysplastic neoplasms (MDS) initiation and progression. Regulatory T cells (Tregs) are central mediators of immunosuppression in MDS. We thus aimed to characterize Treg subpopulations in the bone marrow (BM) of MDS patients and to explore their ...
Romain Vazquez   +18 more
wiley   +1 more source

Giant cell tumor of the distal ulna: a case report

open access: yesJournal of Medical Case Reports, 2012
Introduction Several cases of long bone giant cell tumor have been reported in the literature. We report the case of a patient with a giant cell tumor in the distal ulna. This is very unusual, with a reported incidence of 0.45 to 6%.
Vanni Daniele   +4 more
doaj   +1 more source

A preclinical model for the ATLL lymphoma subtype with insights into the role of microenvironment in HTLV-1-mediated lymphomagenesis [PDF]

open access: yes, 2018
\uef7f View references (83) Adult T cell Leukemia/Lymphoma (ATLL) is a mature T cell malignancy associated with Human T cell Leukemia Virus type 1 (HTLV-1) infection.
Adriana Mattiolo   +8 more
core   +2 more sources

Giant-cell tumor of bone: treatment options and role of denosumab

open access: yesBiologics: Targets & Therapy, 2015
Arun S Singh,1 Neal S Chawla,2 Sant P Chawla2 1Sarcoma Service, Division of Hematology/Oncology, University of California, Los Angeles, 2Sarcoma Oncology Center, Santa Monica, CA, USA Abstract: Giant-cell tumor of bone is a rare, locally aggressive ...
Singh AS, Chawla NS, Chawla SP
doaj  

Giant cell tumor of soft tissue of hand: simple but rare diagnosis, which is often missed

open access: yesClinics and Practice, 2011
Giant cell tumor of soft tissue originally described in 1972 in two different series by Salm and Sissons is a rare entity, which is clinically and histopathologically indistinguishable from giant cell tumor of bone.
Sarwan Kumar, Lynn F. Carter
doaj   +1 more source

Genetic Predictors of Progression and Skin Rash in Japanese mCSPC Patients Treated With Apalutamide: CUARTET Study

open access: yesCancer Science, EarlyView.
In patients with mCSPC treated with apalutamide plus ADT, baseline ctDNA predicted earlier progression to CRPC and worse overall survival. Exploratory genome‐wide analysis identified 12 SNPs associated with apalutamide‐related skin rash. ABSTRACT Despite promising evidence of the efficacy of the androgen deprivation therapy (ADT) plus apalutamide in ...
Masaki Shiota   +8 more
wiley   +1 more source

Wide Resection and Iliac Crest Arthrodesis for Multiply Recurrent Giant Cell Tumor of First Metatarsal

open access: yesCase Reports in Orthopedics, 2018
Case. Giant cell tumor of bone is a benign, aggressive neoplasm commonly arising in the femur, tibia, and distal radius and less commonly in the hands and feet.
Andrew Golz   +3 more
doaj   +1 more source

Primary mediastinal giant cell tumor

open access: yesRare Tumors, 2009
Giant cell tumor of soft tissue is a rare tumor first described by Salm and Sissons in 1972 as being a distinct entity.1 Histologically, it is composed of multinucleated giant cells dispersed among mononuclear cells, and is indistinguishable from its ...
Jela Bandovic   +3 more
doaj   +1 more source

Acromegaly: pathogenesis & treatment [PDF]

open access: yes, 2019
Acromegaly is a multi-system disorder whose etiology is most often traced back to a growth hormone-secreting pituitary adenoma (PA). Growth hormone (GH) secretion promotes insulin-like growth factor 1 (IGF-1) release from peripheral tissues, leading to ...
Tilvawala, Megha
core  

Chondroblastoma of the Clivus: Case Report and Review. [PDF]

open access: yes, 2015
Background and Importance Chondroblastoma is a benign primary bone tumor that typically develops in the epiphyses of long bones. Chondroblastoma of the craniofacial skeleton is extremely rare, with most cases occurring in the squamosal portion of the ...
Ahmadpour, Arjang   +5 more
core   +1 more source

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