Results 141 to 150 of about 166,449,558 (233)

Making the Case for Organ‐on‐Chip Platforms in Long‐Acting Therapeutics Development

Advanced Healthcare Materials, Volume 15, Issue 36, 25 September 2026.
LATs release drug from a tissue‐resident depot over weeks to months, improving adherence, but their development is hampered by preclinical models that cannot reproduce the coupled tissue processes, sustained release, local microenvironment change, interstitial transport, immune and foreign‐body responses, and clearance that govern depot performance in ...
Charlie Gowans, Abdulwahhab Khedr, Panagiotis G. Georgiou, Nehir Arik, Ozlem Sen, Steve P. Rannard, Tom O. McDonald, Christos Tapeinos   +7 more
wiley   +1 more source

Allosteric Inhibition of Polycomb Repressive Complex 2 by an EZH2‐Selective Small Molecule Inhibitor

Advanced Science, Volume 13, Issue 49, 3 September 2026.
The study characterizes C36, a highly selective EZH2/PRC2 inhibitor that acts via a novel allosteric mechanism. Unlike previous inhibitors, C36 inhibits EZH2/PRC2 by disrupting the allosteric communication between EZH2 and EED in a SAM‐noncompetitive manner.
Ting Cao, Dongdong Liu, Haishan Gao, Chenyang Qin, Wen Zhang, Ziyun Lu, Dongxia Tan, Yuxiu Qu, Yusong Liu, Zhiran Zou, Hongtao Yu, Wei Qi   +11 more
wiley   +1 more source

Harnessing blood clot as a native scaffold for orchestrating tissue repairs and regeneration

BMEMat, Volume 4, Issue 3, September 2026.
The blood clot, owing to its dynamic composition and unique microenvironment, holds significant yet underappreciated potential for tissue engineering. This review systematically summarizes the pathophysiology of clot formation, the key regulatory factors shaping its microenvironment, and its applications in both pre‐clinical and clinical settings ...
Gao‐peng Dang, Yu‐zhu Wang, Yi‐fei Wang, Que Bai, Jia‐xin Hao, Zhi‐ting Li, Xiao‐qing Cao, Yu Wei, Yue Feng, Ji‐hua Chen, Franklin R. Tay, Rui‐bing Wang, Jun‐ting Gu, Li‐na Niu   +13 more
wiley   +1 more source

Severe Multiorgan Failure Triggered by Infection in an Adult With Decades of Untreated Sickle Cell Disease: A Case Report

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT A 67‐year‐old man with decades of untreated sickle cell disease developed septic shock with multiorgan failure, splenic infarction, and marrow fibrosis; his genotype could not be confirmed. He recovered with intensive supportive care, with hydroxyurea initiated for long‐term disease modification, illustrating catastrophic infection‐triggered ...
Sara Shahidi, Gisha Mohan
wiley   +1 more source

Bizarre Parosteal Osteochondromatous Proliferation of the Foot: Case Report and Review of Cases Published in the Last 15 Years

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Bizarre parosteal osteochondromatous proliferation is an exceedingly rare bone tumor that mimics malignant lesions both clinically and radiologically. Atypical imaging findings, such as cortical erosion, may bias the differential diagnosis toward malignant tumors.
Jacobo Kerbel, Iturbide Andrés Ponce de León‐Sandoval, Emilio Remolina Sánchez Rucobo, Roberto Berebichez‐Fridman, Enrique Berebichez‐Fastlicht   +4 more
wiley   +1 more source

Large Undifferentiated Sarcoma of the Liver: A Rare Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Undifferentiated embryonal sarcoma of the liver (UESL) is a rare pediatric malignancy requiring prompt histopathological diagnosis. Neoadjuvant chemotherapy followed by extended right hepatectomy can achieve complete tumor necrosis with negative margins. A multidisciplinary approach is essential for favorable outcomes in pediatric UESL.
Hanzala Zahid, Talha Khalid, Moeez Ahmad Saeed, Salman Riaz, Ahmed Hassan, Arham Saif, Kashaf Imtiaz, Muhammad Husnain Ahmad   +7 more
wiley   +1 more source

An In Vitro and In Vivo Assessment of the Anti‐Breast Cancer Activity of Erythrina excelsa Baker (Fabaceae) Bark Extracts

Cancer Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background Breast cancer remains a topic of interest due to its high mortality rate among Cameroonian women. The barks of Erythrina excelsa are traditionally used for medicinal purposes in the management of various conditions including cancer.
Jonas Walantini, Marius Trésor Kemegne Sipping, Merline Nguedia Ymele, Roland Nhouma Rebe, Joël Abel Gbaweng Yaya, Derek Tantoh Ndinteh, Dieudonné Njamen, Stéphane Zingue   +7 more
wiley   +1 more source

What's new on giant cell tumor of bone. [PDF]

SICOT J
Tsukamoto S, Errani C, Balach T, Zamora T, Ortiz-Cruz E, Rajasekaran RB, Yau R, Ji T, Pérez-Muñoz I, Linares F, Angelini A, Ruggieri P, Benevenia J, Mavrogenis AF.   +13 more
europepmc   +1 more source

Cardiovascular Immune‐Related Adverse Events of Immune Checkpoint Inhibitors: A Systematic Review and Meta‐Summary of Case Reports

Cancer Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background Reports of immune checkpoint inhibitor (ICI) therapy‐associated immune‐related adverse events (irAEs) exhibit considerable heterogeneity, particularly when comparing data from clinical trials and real‐world observational studies. Methods We conducted a systematic review of real‐world observational studies (case reports and series ...
Shea‐Lee Godin, Tyler Kingma, Ashwin Pillai, Obada Kholoki, Agnes S. Kim   +4 more
wiley   +1 more source

Giant cell tumor of bone: exploring HtrA1 as a potential predictor of recurrence. [PDF]

Arch Orthop Trauma Surg
Mirioglu A, Dalkir KA, Gokmen MY, Bagir M, Ates KE, Deveci MA, Gönlüşen G, Ozbarlas HS.   +7 more
europepmc   +1 more source