Results 141 to 150 of about 64,522 (303)
Advanced Science, Volume 13, Issue 25, 4 May 2026.The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo +8 more
wiley +1 more source
Cancer Medicine, Volume 15, Issue 5, May 2026.ABSTRACT Background Pulmonary sarcomatoid carcinoma (PSC) is a rare and highly aggressive tumor. This study aimed to investigate the prognostic factors of PSC and develop a new risk classifier to predict patients' overall survival (OS). Methods This retrospective study consisted of 675 PSC patients registered in the Surveillance, Epidemiology, and End ...
Shuwen Cui +13 more
wiley +1 more source
When an Oral Lesion Uncovers Hyperparathyroidism: A Peripheral Brown Tumor Case
Clinical Case Reports, Volume 14, Issue 5, May 2026.ABSTRACT Oral lesions may represent the first sign of an underlying systemic disease. Giant cell lesions in the oral cavity should prompt investigation for hyperparathyroidism, as early recognition of brown tumors allows appropriate systemic management and may lead to lesion regression after treatment of the endocrine disorder.
Bruno Teixeira Gonçalves Rodrigues +6 more
wiley +1 more source
Rankl expression as a prognostic marker in stage III giant cell tumour of the bone [PDF]
, 2015 Introduction: Giant cell tumour of bone is an aggressive benign bone tumor composed of unstable spindle shaped neoplastic mononuclear stromal cells and reactive components osteoclast like giant cells. GCT in Asian population including Malaysia, presented
Abdul Ghani , Nur Sabrina
core
The prognosis of giant cell tumor of bone and the vital risk factors that affect its postoperative recurrence: a meta-analysis [PDF]
, 2021 Xunge Lin, Jiaqi Liu, Meng Xu
openalex +1 more source
Hydatid Cyst of the Thyroid Gland With Concurrent Hepatic Involvement: A Rare Case Report
Clinical Case Reports, Volume 14, Issue 5, May 2026.ABSTRACT Hydatidosis, caused by Echinococcus granulosus, most commonly affects the liver and lungs, while thyroid involvement is exceptionally rare and can mimic other cystic thyroid lesions. We report a 40‐year‐old woman with no history of animal exposure who presented with anterior neck swelling, odynophagia, and abdominal discomfort. She had a prior
Hana Saffar, Aysan Nozheh, Maral Edalati
wiley +1 more source
Clinical Case Reports, Volume 14, Issue 5, May 2026.ABSTRACT Aggressive lumbar osteoblastoma with secondary aneurysmal bone cysts is rare and may involve both posterior elements and vertebral bodies. When extensive multilevel involvement is present, a combined posterior and transpsoas approach can facilitate complete tumor resection, restore spinal stability, and achieve favorable neurological and ...
Enliang Chen +8 more
wiley +1 more source