Results 191 to 200 of about 167,867,171 (233)

Giant cell tumour of bone

Bone and Joint Journal, 2023
Giant cell tumour of bone (GCTB) is a locally aggressive lesion that is difficult to treat as salvaging the joint can be associated with a high rate of local recurrence (LR). We evaluated the risk factors for tumour relapse after treatment of a GCTB of the limbs.
Ahmed Aoude   +2 more
exaly   +5 more sources

MULTIPLE GIANT-CELL TUMOUR OF BONE

open access: yesThe Journal of Bone and Joint Surgery. British volume, 1973
1. A case is described of three giant-cell tumours, the first in 1966 in the lower left femur, the second in 1968 in the upper right femur, the third later in 1968 in the upper left femur. 2. None of the tumours could be described as frankly malignant. 3.
S, Sybrandy, A A, De la Fuente
openaire   +3 more sources

Giant cell tumour of bone in the denosumab era

European Journal of Cancer, 2017
Giant cell tumour of bone (GCTB) is an intermediate locally aggressive primary bone tumour, occurring mostly at the meta-epiphysis of long bones. Overexpression of receptor activator of nuclear factor kappa-B ligand (RANKL) by mononuclear neoplastic stromal cells promotes recruitment of numerous reactive multinucleated osteoclast-like giant cells ...
Jean-Yves Blay   +2 more
exaly   +4 more sources

Radiosensitive giant cell tumour of the sphenoid bone

British Journal of Neurosurgery, 2001
Giant cell tumours rarely occur in the cranial region. We encountered a radiosensitive giant cell tumour of the sphenoid in a 12-year-old girl. After a two-stage operation, the residual tumour regrew rapidly. The adjuvant radiotherapy subsequent to additional surgery has suppressed the growth of the residual tumour for 5 years.
H, Kishima, Y, Miyao, K, Shimizu
exaly   +3 more sources

Malignant giant cell tumour of bone: a review of clinical, pathological and imaging features

open access: yesSkeletal Radiology, 2021
Giant cell tu mour accounts for up to 5% of all bone tumours and malignant giant cell tumour arises in \u3c 10% of cases, representing sarcomatous transformation.
Ismail Tahir
exaly   +2 more sources

Telomere biology in giant cell tumour of bone†

Journal of Pathology, 2008
AbstractGiant cell tumour of bone (GCTB) is a benign bone tumour known for the unpredictable clinical behaviour of recurrences and, in rare instances, distant metastases. It consists of uniformly distributed osteoclastic giant cells in a background of mononuclear rounded and spindle‐shaped cells.
Ramses Forsyth, Sofie Bekaert
exaly   +4 more sources

Giant cell tumour of bone

Current Opinion in Oncology, 2009
Giant cell tumour of bone (GCT) is the most common benign bone tumour and afflicts a young population. Treatment options for patients with unresectable disease have remained fairly static for the past three decades.Recent discoveries have identified a key role for the osteoclast differentiation factor, receptor activator of nuclear factor kappa B (NF ...
David M, Thomas, Keith M, Skubitz
openaire   +2 more sources

An unusual giant cell tumour of bone

International Orthopaedics, 1981
This is a report of an 18-year old girl with an unusual giant cell tumour. Although it is difficult to distinguish between a multifocal giant cell tumour of bone and a primary giant cell tumour with metastases in other bones, we believe that our case is either a multicentric or a multifocal giant cell tumour.
Bose, K., Sinniah, R.
openaire   +2 more sources

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