Results 41 to 50 of about 12,514,294 (303)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Nodal and cripto-1: distinct functions regulate trophoblast specification in mouse pregnancy

Frontiers in Cell and Developmental Biology
IntroductionProper placentation is essential for fetal growth and development in mammals. Nodal signaling is essential to ensure proper embryo development and requires Cripto-1 as a co-receptor.
Laura Girardet, Laura Girardet, Neha Kamath, Neha Kamath, Daniel Dufort, Daniel Dufort   +5 more
doaj   +1 more source

Multinucleated Giant Cancer Cells Produced in Response to Ionizing Radiation Retain Viability and Replicate Their Genome

International Journal of Molecular Sciences, 2017
Loss of wild-type p53 function is widely accepted to be permissive for the development of multinucleated giant cells. However, whether therapy-induced multinucleation is associated with cancer cell death or survival remains controversial.
R. Mirzayans, B. Andrais, A. Scott, Y. Wang, Piyush Kumar, D. Murray   +5 more
semanticscholar   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Functional studies of plant transcription factors and their relevance in the plant root-knot nematode interaction

Frontiers in Plant Science
Root-knot nematodes are polyphagous parasitic nematodes that cause severe losses in the agriculture worldwide. They enter the root in the elongation zone and subtly migrate to the root meristem where they reach the vascular cylinder and establish a ...
Jose Domínguez-Figueroa, Jose Domínguez-Figueroa, Almudena Gómez-Rojas, Carolina Escobar   +3 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Floret-like multinucleated giant cells in neurofibroma

Diagnostic Pathology, 2007
This short report discusses a case of neurofibroma containing floret-like multinucleated giant cells. This being the second such case in the literature.
Golka Dariusz, Shaktawat Sameer
doaj   +1 more source

Transcriptional analysis through RNA sequencing of giant cells induced by Meloidogyne graminicola in rice roots

Journal of Experimental Botany, 2013
One of the reasons for the progressive yield decline observed in aerobic rice production is the rapid build-up of populations of the rice root knot nematode Meloidogyne graminicola.
H. Ji, G. Gheysen, S. Denil, K. Lindsey, J. Topping, K. Nahar, A. Haegeman, W. D. De Vos, G. Trooskens, W. van Criekinge, T. de Meyer, T. Kyndt   +11 more
semanticscholar   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Granuloma with langhans giant cells: An overview

Journal of Oral and Maxillofacial Pathology, 2013
Granuloma formation with multinucleated giant cells is seen in numerous diseases. A granuloma is a focus of chronic inflammation consisting of a microscopic aggregation of macrophages surrounded by a collar of lymphocytes and plasma cells.
SNalin Kumar, TSrinivasa Prasad, P. Narayan, J. Muruganandhan   +3 more
semanticscholar   +1 more source