Results 91 to 100 of about 607,978 (313)

Problemas e tensões entre as noções de produção, propriedade intelectual e cultura

Horizontes Antropológicos, 2012
Neste artigo, analiso as relações entre as noções de produção, propriedade intelectual e cultura. Partindo das articulações entre inventor e invenção, mostro quais caminhos problematizam a categoria da propriedade intelectual, sublinhando dualidades do ...
Guilherme Francisco Waterloo Radomsky
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

سُنن ِ الٰہیہ اورتکوینی قوانین : قرآنی آیات کی روشنی میں تعارفی مطالعہ

Pakistan Journal of Islamic Research
The scientific knowledge has discovered that a set of laws govern the whole universe; ranging from a particle of sand to a galaxy of stars and planets.  According to the scientists, the Nature has prescribed these laws, therefore, the laws are named as ...
Muti ur Rehman Bhutto, Mustafeez Ahmad Alvi   +1 more
doaj  

External Validation of the Traumatic Bleeding Severity Score for the Predictive Accuracy of the Need for Massive Transfusion

Acute Medicine & Surgery
Background The Traumatic Bleeding Severity Score (TBSS), developed in Japan, has shown high predictive accuracy in internal validation; however, external validation has still not been performed.
Kei Kimoto, Akira Endo, Atsushi Shiraishi, Kensuke Fujita, Takuya Kimura, Yoshihiro Hagiwara, Takayuki Ogura, J‐OCTET 2 Study Group   +7 more
doaj   +1 more source

“Mais vint un second jour”. Pour Yves Bonnefoy

Lea, 2016
This short article intends to honour the poet Yves Bonnefoy who died recently. His “passing away” as a perpetual movement seems to confirm his poetics of presence which he had been evoking throughout his life.
Michela Landi
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Individual vs. collective contracts: An experimental investigation using the gift exchange game [PDF]

This paper compares individual with collective contracts using modified repeated gift exchange games. The game had two variations, both following a partner design. In the individual variation different workers in the same firm can receive separate wages,
Sophia Chong, Pablo Guillen
core  

Diabetes Millitus Control Exogenous Insulin Infusion: A Review

Pakistan Journal of Engineering & Technology, 2020
Diabetes Millitus Control remains popular from the past years to explore for more investigations. Exogenous Insulin infusion is explored in the study for further analysis. Administration of Insulin delivery has been discussed for type-1 patients.
Vince Wang , Qasim Awais
doaj  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source