Results 71 to 80 of about 4,982 (197)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Problemas e tensões entre as noções de produção, propriedade intelectual e cultura

Horizontes Antropológicos, 2012
Neste artigo, analiso as relações entre as noções de produção, propriedade intelectual e cultura. Partindo das articulações entre inventor e invenção, mostro quais caminhos problematizam a categoria da propriedade intelectual, sublinhando dualidades do ...
Guilherme Francisco Waterloo Radomsky
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

External Validation of the Traumatic Bleeding Severity Score for the Predictive Accuracy of the Need for Massive Transfusion

Acute Medicine & Surgery
Background The Traumatic Bleeding Severity Score (TBSS), developed in Japan, has shown high predictive accuracy in internal validation; however, external validation has still not been performed.
Kei Kimoto, Akira Endo, Atsushi Shiraishi, Kensuke Fujita, Takuya Kimura, Yoshihiro Hagiwara, Takayuki Ogura, J‐OCTET 2 Study Group   +7 more
doaj   +1 more source

“Mais vint un second jour”. Pour Yves Bonnefoy

Lea, 2016
This short article intends to honour the poet Yves Bonnefoy who died recently. His “passing away” as a perpetual movement seems to confirm his poetics of presence which he had been evoking throughout his life.
Michela Landi
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Diabetes Millitus Control Exogenous Insulin Infusion: A Review

Pakistan Journal of Engineering & Technology, 2020
Diabetes Millitus Control remains popular from the past years to explore for more investigations. Exogenous Insulin infusion is explored in the study for further analysis. Administration of Insulin delivery has been discussed for type-1 patients.
Vince Wang , Qasim Awais
doaj  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Solution‐Processed Organic Photovoltaics: Fabrication Advances and Challenges

Advanced Science
The growing demand for sustainable energy solutions has propelled organic solar cells (OSCs) into the spotlight as a promising alternative to traditional inorganic photovoltaics.
Kerui Liu, Chenyujie Zhu, Yuanyuan Jiang, Feng Liu, Xiaozhang Zhu   +4 more
doaj   +1 more source