Results 61 to 70 of about 436,846 (267)
The role of immunity in comorbid pain and depression
Exploration of ImmunologyThe narrative review aims to shed light on the influence of inflammation in the comorbid chronic pain and major depressive disorder (MDD). This connection is known to be multifactorial, with a dynamic interaction between genetic and epigenetic factors ...
Antonella Ciaramella, Giancarlo Carl
doaj +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
A Corpus Analysis of Metaphorical Expressions in Covid-19 Open Research Dataset(CORD19)
Corporum, 2021 Metaphors play a significant role in shaping our thoughts and processes of communication. They are extensively used in everyday language and hence are an indispensable part of shaping human thought and language structures.
Shazia Riaz Dar
doaj
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Critical Care ExplorationsOBJECTIVE:. To assess physician acceptance of a Virtual Reality Brain Death Determination Tool (VRBDDT) as an educational modality and its impact on physician knowledge and confidence in brain death determination and communication with patient families ...
Mikel S. Ehntholt, MD +6 more
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Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
سُنن ِ الٰہیہ اورتکوینی قوانین : قرآنی آیات کی روشنی میں تعارفی مطالعہ
Pakistan Journal of Islamic ResearchThe scientific knowledge has discovered that a set of laws govern the whole universe; ranging from a particle of sand to a galaxy of stars and planets. According to the scientists, the Nature has prescribed these laws, therefore, the laws are named as ...
Muti ur Rehman Bhutto +1 more
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FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Un’educazione fondata sulla restituzione
Studi sulla Formazione, 2017 To an education policy increasingly subject to the rules imposed by market, production and competition expectations, I mean to counteract a policy of restitution, such as the commitment to protect every young person from the pressure of exploitation and ...
Paolo Mottana
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