Results 61 to 70 of about 4,982 (197)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Un’educazione fondata sulla restituzione

Studi sulla Formazione, 2017
To an education policy increasingly subject to the rules imposed by market, production and competition expectations, I mean to counteract a policy of restitution, such as the commitment to protect every young person from the pressure of exploitation and ...
Paolo Mottana
doaj   +1 more source

Gifted Is as Gifted Does

Academic Leadership: The Online Journal, 2011
In the last decades, interest in instructional process has drawn the attention of linguists to classroomdiscourse studies (Lee, 2007; Chen, 2007; Hall, 2007; Macbeth, 2004). Such growing attention hasbeen attributed to the importance associated with verbal discourse in meaning making (Chin, 2006).Chin further notes that a common ground available in the
Theresa Monaco, null null, null null, null null   +3 more
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

The Gift of Oneself from the Perspective of New Readings of “The Gift” by Marcel Mauss

Journal for Perspectives of Economic Political and Social Integration, 2014
The Gift: Forms and Functions of Exchange in Archaic Societies, by Marcel Mauss, is an important reference in Social Sciences for thinking about the theme of the gift, proposed in this congress.
Malatesta Freitas Maria Do Socorro
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A Novel Screen-Based Virtual Reality Tool for Teaching Brain Death Determination: A Pilot Study of the Virtual Reality Brain Death Determination Tool

Critical Care Explorations
OBJECTIVE:. To assess physician acceptance of a Virtual Reality Brain Death Determination Tool (VRBDDT) as an educational modality and its impact on physician knowledge and confidence in brain death determination and communication with patient families ...
Mikel S. Ehntholt, MD, Patricia A. Mulvania, RN, BSN, CPTC, Theresa A. Daly, MS, BS, Andrea L. C. Schneider, MD, PhD, Monisha A. Kumar, MD, FNCS, Richard D. Hasz, Joshua M. Levine, MD, FANA, FNCS   +6 more
doaj   +1 more source

From Man as Predator to Man as Giver. Reflections on the Gift and the Self-Giving in Psychology

Journal for Perspectives of Economic Political and Social Integration, 2014
Considering the values and the cultural model today prevailing, all centred on narcissistic individualism and extreme competition, Chiara Lubich’s thought on gift and self – giving is likely to look ingenuous and absurd.
Cavaleri Pietro A
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

سُنن ِ الٰہیہ اورتکوینی قوانین : قرآنی آیات کی روشنی میں تعارفی مطالعہ

Pakistan Journal of Islamic Research
The scientific knowledge has discovered that a set of laws govern the whole universe; ranging from a particle of sand to a galaxy of stars and planets.  According to the scientists, the Nature has prescribed these laws, therefore, the laws are named as ...
Muti ur Rehman Bhutto, Mustafeez Ahmad Alvi   +1 more
doaj