Results 41 to 50 of about 436,846 (267)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

“Cat scratch colon” causing cecal perforation as a rare complication due to barotrauma during colonoscopy: A case report and literature review

DEN Open
“Cat scratch colon” (CSC), characterized by spontaneous bright‐red linear markings or mucosal laceration with bleeding due to air insufflation barotrauma, is a rare complication during colonoscopy.
Hitoshi Hara, Yasuhide Muto, Tomoki Kido, Ryohei Miyata, Moe Tokuda, Tomohiro Maesono, Takahiro Ajihara, Takuma Naritomi, Michio Itabashi   +8 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Role of Narcissism in Entrepreneurial Traits Mediated by Entrepreneurial Intention and Entrepreneurial Motivation among University Students

Journal of Management and Research
This study investigates the influence of narcissism and entrepreneurial ambition on entrepreneurial intention and self-efficacy in students studying entrepreneurship.
Umer Ejaz, Ali Hassan, Abu Huraira, Shahzada Adeel   +3 more
doaj   +1 more source

Gift Cards and Gift Giving

Journal of Applied Marketing Theory, 2013
Gift cards are frequently located at premium points inside the retail space where stores sell not only their own cards but also other retailers’ cards for almost every occasion. Media encouraged practitioners to promote these cards.
Melek Anitsal, Ismet Anitsal, Amanda Brown   +2 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Apnea Testing for Brain Death/Death by Neurologic Criteria in Adults: A Prospective Multicenter Observational Study Assessing the Relationship Between Methodology, Safety, and Duration

Critical Care Explorations
IMPORTANCE:. Apnea testing is an integral component of brain death (BD) assessments. The optimal method of Apnea Testing is currently not known. OBJECTIVES:.
Sean Cuninghame, MD, MSc, FRCPC, John Basmaji, MD, MSc, FRCPC, James Duffin, PhD, Andrew Healey, MD, FRCPC, Beth Paltser, MSc, Michelle Snyder-Salehi, RN, BScN, Alexander Yoshiki, BScE, J. Gordon Boyd, MD, PhD, FRCPC, Michael Hartwick, MD, FRCPC, Karim Soliman, MD, FRCPC, Jeffrey M. Singh, MD, MSc, FRCPC, David Katz, MD, MSc, FRCPC, Janice Beitel, RN, Ebenezer Ogunsakin, PhD, Marat Slessarev, MD, PhD, FRCPC   +14 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source