Results 41 to 50 of about 763,846 (258)
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
, 2002 Advancement, a supplement to Bostonia magazine, provided updates on BU development activities, including major gifts and ...
Boston University Office of Development and Alumni Relations
core
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
, 2008 Advancement, a supplement to Bostonia magazine, provided updates on BU development activities, including major gifts and ...
Boston University Office of Development and Alumni Relations
core
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Advancement, Spring 2005 [PDF]
, 2005 Advancement, a supplement to Bostonia magazine, provided updates on BU development activities, including major gifts and ...
Boston University Office of Development and Alumni Relations
core
Challenging cases of professionalism in Japan: improvement in understanding of professional behaviors among Japanese residents between 2005 and 2013. [PDF]
, 2015 BackgroundProfessionalism is deemed as the basis of physicians' contract with society in Japan. Our study in 2005, using a questionnaire with scenarios to professionalism, suggested that many physicians at various levels of training in Japan encounter ...
Barnett, Peter B +3 more
core +2 more sources
Aging and Cancer, EarlyView.ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef +2 more
wiley +1 more source
2013 Fundraising Effectiveness Survey Report [PDF]
, 2013 The 2013 Fundraising Effectivenes Project Report summarizes data from 2,840 survey respondents covering year-to-year fundraising results for 2011-2012.
core
Gifts from Exoplanetary Transits [PDF]
, 2009 The discovery of transiting extrasolar planets has enabled us a number of interesting stduies. Transit photometry reveals the radius and the orbital inclination of transiting planets, and thereby we can learn the true mass and the density of respective ...
Miki Ishii +3 more
core +2 more sources