Results 161 to 170 of about 532,493 (260)

Buserelin Improves Ovulation-Embryo Synchrony Compared With hCG After eCG-Induced Superovulation in Donor Sows. [PDF]

open access: yesReprod Domest Anim
Lopez-Jara A   +7 more
europepmc   +1 more source

GH172 Difructose Dianhydride I Synthase: A Two‐Stepped Journey via Glycosylation and Cyclization Using QM/MM Metadynamics

open access: yesChemistry – A European Journal, EarlyView.
Unlocking the chemistry of caramel by simulations and experimental validation. αFFase1${\alpha }\rm{FFase1}$ converts inulobiose into difructose dianhydride I, one component of caramel, through two steps: a rate‐limiting glycosylation (with a rare sugar ring flip) followed by a cyclization step, guided by residues E85, K147, and N226.
Santiago Alonso‐Gil   +7 more
wiley   +1 more source

Mosaic TLR8 gain-of-function in an elderly female treated with JAK inhibitor and adjunctive therapy. [PDF]

open access: yesJ Hum Immun
Patel JA   +10 more
europepmc   +1 more source

En la puerta de su casa de la calle Caballeros los Gil Roca al regreso de la romería

open access: yes, 1948
En la puerta de su casa de la calle Caballeros los Gil al regreso de la romería, cansados pero muy contentos de la experiencia. Sentado delante Juan Gil Roca, detrás de I a D; Tonica Gil Roca, José Miguel Martí Gil, Vicentino Martí Gil, Lidón Gil Roca ...
Gil Roca, Elías
core  

Motor Physiology Transcranial Magnetic Stimulation–Based Biomarkers and Associated Neurocognitive Profiles in Attention‐Deficit/Hyperactivity Disorder

open access: yesAnnals of the Child Neurology Society, EarlyView.
ABSTRACT Purpose Attention‐deficit/hyperactivity disorder (ADHD) is a highly prevalent and heterogeneous neurodevelopmental condition for which current diagnostic approaches rely on symptom‐based classifications that do not capture underlying neurobiology.
Alyssa C. DeRonda   +7 more
wiley   +1 more source

Pediatric Developmental Safety Assessment: Are We Ready for the Next Thalidomide?

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Pediatric drug development has achieved remarkable success in the last 20 years with over 1,000 products studied in pediatric patients. This success has been driven in part by an increased understanding of pediatric disease processes. The aspect that has been largely overlooked is the potential adverse effect of new drugs on pediatric developmental ...
Gilbert J. Burckart   +6 more
wiley   +1 more source

Empirical PK/PD Model for Differentiating Intrinsic Dosing Rules by Therapeutic Indication With Relevance for HIV‐1 Latency Reversal

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Romidepsin (RMD), an FDA‐approved histone deacetylase inhibitor for treating cancer, demonstrates potent latency‐reversing activity in vitro but has yielded suboptimal outcomes in kick‐and‐kill HIV‐cure trials when administered as a 5 mg/m2 infusion.
Lauren A. R. Tompkins   +7 more
wiley   +1 more source

Pediatric Developmental Safety Assessment and New Approach Methodologies: US FDA/Triangle CERSI Workshop Report

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Pediatric developmental safety assessment presents distinct challenges in drug development. Children undergo dynamic changes in organ systems and drug disposition pathways during development, and drug‐related effects may be delayed or manifested differently than in adults.
Gilbert J. Burckart   +16 more
wiley   +1 more source

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