Results 121 to 130 of about 57,539 (299)
Advanced Science, EarlyView.MarginPath is a novel vision‐language system that automates breast cancer margin assessment using a single label‐free multiphoton microscopy image. By integrating tumor‐associated collagen signatures with virtual H&E imaging, it generates accurate margin heatmaps and comprehensive diagnostic reports.
Shu Wang +15 more
wiley +1 more source
Advanced Science, EarlyView.Pseudorabies virus (PRV), an emerging zoonotic α‐herpesvirus, causes life‐threatening human encephalitis. We identified a broad‐spectrum neutralizing antibody 6F7 targeting PRV gD. It blocks gD‐Nectin‐1 binding and membrane fusion, inhibiting replication across all PRV variants, representing a promising candidate for anti‐PRV therapy.
Yue Sun +11 more
wiley +1 more source
In memoriam : Gilbert Theo Hinze: 1943 - 2024
Article originally published in VetNews, September 2024, the monthly magazine of the South African Veterinary AssociationGilbert Hinze was born on 22 October 1943 in Paulpietersburg, KwaZulu-Natal and grew up on his parent’s farm in the Commondale ...
Turner, Vincent
core
AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint
Advanced Science, EarlyView.AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz +4 more
wiley +1 more source
Open Life SciencesA congenital protein anomaly in the erythrocyte membrane skeleton causes a hereditary haemolytic illness known as hereditary spherocytosis (HS). The primary characteristic of HS is an increase in the number of tiny spherical red blood cells in the ...
Chi Changwei +5 more
doaj +1 more source
Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies
Advanced Science, EarlyView.In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang +4 more
wiley +1 more source
When is an ounce of prevention worth a pound of cure: The case of cardiovascular disease? [PDF]
Objective: To provide decision makers with a tool to inform resource allocation decisions at the local level, using cardiovascular disease prevention as an example.
Marion Haas +3 more
core
stMixer for Scalable Mosaic Integration and Label Transfer in Spatial Histology and Multi‐Omics
Advanced Science, EarlyView.stMixer is an unsupervised framework for scalable integration and label transfer across spatial histology and multi‐slide multi‐omics data with incomplete modality overlap. It combines self‐looped cross‐attention, multimodal metric learning, and graph‐guided cluster voting to align heterogeneous sections, correct batch effects, and propagate ...
Qixing Yang +3 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun +10 more
wiley +1 more source
Advanced Science, EarlyView.An edible biohybrid platform triggers nanoplastics (NPs) aging and agglomeration by in situ generating hydroxyl radicals within the intestine. The enlarged NPs are unable to penetrate the intestine and are subsequently excreted. Simultaneously, probiotic biofilms reinforce the intestinal barrier.
Su Zhou +4 more
wiley +1 more source