Results 1 to 10 of about 242,163 (312)
Scandinavian Journal of Clinical and Laboratory Investigation, 2022 Prolonged icterus is an important and common problem in neonatology and accurate determination of the different bilirubin species, including differentiation between delta-bilirubin and mono- and di-conjugated bilirubin, is useful for diagnostic purposes. However, most bilirubin measurements routinely performed in the clinical laboratory are hampered by
Morten Hjuler Nielsen +3 more
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Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 2017 Background We occasionally encounter increases in direct bilirubin value on reanalysis of the surplus serum collected in the past from a neonate with indirect hyperbilirubinemia. But the details of this phenomenon are unclear.
Hitoshi, Okada +10 more
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Some of the next articles are maybe not open access.
Current Neurology and Neuroscience Reports, 2022
Hyperbilirubinemia is commonly seen in neonates. Though hyperbilirubinemia is typically asymptomatic, severe elevation of bilirubin levels can lead to acute bilirubin encephalopathy and progress to kernicterus spectrum disorder, a chronic condition characterized by hearing loss, extrapyramidal dysfunction, ophthalmoplegia, and enamel hypoplasia ...
Shuo, Qian +2 more
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Hyperbilirubinemia is commonly seen in neonates. Though hyperbilirubinemia is typically asymptomatic, severe elevation of bilirubin levels can lead to acute bilirubin encephalopathy and progress to kernicterus spectrum disorder, a chronic condition characterized by hearing loss, extrapyramidal dysfunction, ophthalmoplegia, and enamel hypoplasia ...
Shuo, Qian +2 more
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Bilirubin Production and the Risk of Bilirubin Neurotoxicity
Seminars in Perinatology, 2011Neonatal jaundice usually occurs in the transitional period after birth, presenting as an elevation of circulating bilirubin. Bilirubin neurotoxicity can occur if the levels of bilirubin become excessive (hyperbilirubinemia). This pathologic phenotype of newborn jaundice can develop because of excessive bilirubin production or impaired conjugation ...
David K, Stevenson +2 more
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Nature, 1976
THE biological breakdown of haem proceeds through a series of intermediates of which the orange-yellow bile pigment, bilirubin, the chromophore responsible for coloration in the various forms of jaundice, is a key member. In the adult human, for example, erythrocytes have a lifetime of about 3 months and their destruction produces about 300 mg ...
R, Bonnett, J E, Davies, M B, Hursthouse
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THE biological breakdown of haem proceeds through a series of intermediates of which the orange-yellow bile pigment, bilirubin, the chromophore responsible for coloration in the various forms of jaundice, is a key member. In the adult human, for example, erythrocytes have a lifetime of about 3 months and their destruction produces about 300 mg ...
R, Bonnett, J E, Davies, M B, Hursthouse
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Nature, 1963
CONJUGATED bilirubins (esters) are formed within the liver cells from bilirubin and glucuronic or sulphuric acid. These compounds are very unstable because of the highly reactive central methylene bridge. They are oxidized rapidly by the air and react immediately with diazotized sulphanilic acid.
J, FOG, E, JELLUM
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CONJUGATED bilirubins (esters) are formed within the liver cells from bilirubin and glucuronic or sulphuric acid. These compounds are very unstable because of the highly reactive central methylene bridge. They are oxidized rapidly by the air and react immediately with diazotized sulphanilic acid.
J, FOG, E, JELLUM
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Pediatrics, 1971
Current concepts of the mechanisms of biotransformation and drug detoxification evolved largely as a result of studies of the last decade and a half.1 It was demonstrated that most of the enzyme systems responsible for the oxidative, reductive, hydrolytic, and conjugating reactions of drugs, toxins, and many endogenous substances are located in the ...
M M, Thaler, R, Schmid
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Current concepts of the mechanisms of biotransformation and drug detoxification evolved largely as a result of studies of the last decade and a half.1 It was demonstrated that most of the enzyme systems responsible for the oxidative, reductive, hydrolytic, and conjugating reactions of drugs, toxins, and many endogenous substances are located in the ...
M M, Thaler, R, Schmid
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Pediatrics, 1954
Peripheral blood specimens from cases of varying degree of clinical severity of hemolytic disease of the newborn infant have been examined spectrophotometrically and a curve consistent with the presence of bilirubin was found in each case. Extracts of the pigmented brain areas from five cases of hemolytic disease of the newborn infant ...
W J, WATERS, D A, RICHERT, H H, RAWSON
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Peripheral blood specimens from cases of varying degree of clinical severity of hemolytic disease of the newborn infant have been examined spectrophotometrically and a curve consistent with the presence of bilirubin was found in each case. Extracts of the pigmented brain areas from five cases of hemolytic disease of the newborn infant ...
W J, WATERS, D A, RICHERT, H H, RAWSON
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Plasma bilirubin binding and bilirubin neurotoxicity
Developmental Medicine & Child Neurology, 2016This commentary is on the original article by Amin et al. on pages 297–303 of this issue.
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On the autoxidation of bilirubin
Biochemical and Biophysical Research Communications, 1976Abstract The instability of oxygenated aqueous solutions of bilirubin in the dark is due to several distinguishable processes: autoxidation, surface phenomena and precipitation-aggregation. Autoxidation occurs in aqueous solutions over a pH range 7.4–13.2 in the presence of even traces of oxygen.
David A. Lightner +3 more
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