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Kernicterus Continues to Occur in the USA Despite Concerted Preventive Efforts [PDF]

Case Reports in Pediatrics
Kernicterus spectrum disorder continues to occur in the USA, even after improvements in detecting and managing hyperbilirubinemia were brought about by the 2022 AAP revised guidelines. Three of eight new cases of kernicterus occurring in our state during
Bailey B. Zeiler, Timothy M. Bahr, Robin K. Ohls, Robert D. Christensen   +3 more
doaj   +2 more sources

Clinicopathological Spectrum of Bilirubin Encephalopathy/Kernicterus

Diagnostics, 2019
Bilirubin encephalopathy/kernicterus is relatively rare, but continues to occur despite universal newborn screening. What is more interesting is the spectrum of clinical and even neuropathological findings that have been reported in the literature to be ...
Sumit Das, Frank Van Landeghem
exaly   +3 more sources

Kernicterus [PDF]

Autopsy and Case Reports, 2019
Ameer Hamza
doaj   +4 more sources

MRI of bilirubin encephalopathy (kernicterus): A case series of 4 patients from Sub-Saharan Africa, May 2017

Radiology Case Reports, 2018
Characteristic magnetic resonance imaging (MRI) findings in patients with chronic kernicterus are bilateral and symmetric T2-weighted hyperintensities in the globus pallidus.
Kindu Gebreegziabher, Daniel Solomon, Ayalew Moges   +2 more
exaly   +3 more sources

The Importance of Neuroimaging Follow-Up in Bilirubin-Induced Encephalopathy: A Clinical Case Review [PDF]

Brain Sciences
Introduction: Hyperbilirubinemia in newborns can lead to kernicterus, a severe form of neonatal encephalopathy caused by bilirubin toxicity. Despite timely interventions such as exchange transfusion, kernicterus can still develop, especially in high-risk
Martina Resaz, Alessia Pepe, Domenico Tortora, Andrea Rossi, Luca Antonio Ramenghi, Andrea Calandrino   +5 more
doaj   +2 more sources

Effects of Repetitive Transcranial Magnetic Stimulation on Pallidum GABAergic Neurons and Motor Function in Rat Models of Kernicterus

Brain Sciences, 2023
Kernicterus is a serious complication of hyperbilirubinemia, caused by neuronal injury due to excessive unconjugated bilirubin (UCB) in specific brain areas.
Nanqin Wang, Yongzhu Jia, Xuanzi Zhou, Xia Wang, Huyao Zhou, Nong Xiao   +5 more
doaj   +1 more source

Developmental outcome of severe neonatal indirect hyperbilirubinemia [PDF]

Journal of Research in Clinical Medicine, 2021
Background: Indirect hyperbilirubinemia is one of the most common causes of hospitalization in the neonatal period and its potential association with brain damage is well established.
Manizheh Mostafa Gharehbaghi, Seifolah Heidatabady, Masoomeh Ghasempour, Mahsa Alizade   +3 more
doaj   +1 more source

Free Bilirubin Induces Neuro-Inflammation in an Induced Pluripotent Stem Cell-Derived Cortical Organoid Model of Crigler-Najjar Syndrome

Cells, 2023
Bilirubin-induced neurological damage (BIND), which might progress to kernicterus, occurs as a consequence of defects in the bilirubin conjugation machinery, thus enabling albumin-unbound free bilirubin (BF) to cross the blood–brain barrier and ...
Abida Islam Pranty, Wasco Wruck, James Adjaye   +2 more
doaj   +1 more source

Genetic Association of UGT1A1 Promoter Variants (c.-3279T>G and c.-3156G>A) with Neonatal Hyperbili-rubinemia in an Iranian Population [PDF]

Iranian Journal of Neonatology, 2021
Background: Several studies have reported that two promoter variants (c.-3279T>G and c.-3156G>A) in UDP-glucuronosyltransferase (UGT1A1) gene may contribute to neonatal hyperbilirubinemia.
Nasim Pouralizadeh, Gholamali Mamouri, Abbas Boskabadi, Hassan Boskabadi, Houshang Rafatpanah, Ali Moradi, Hassan Mehrad-Majd   +6 more
doaj   +1 more source

MGE-Like Neural Progenitor Cell Survival and Expression of Parvalbumin and Proenkephalin in a Jaundiced Rat Model of Kernicterus

Cell Transplantation, 2022
Kernicterus is a permanent condition caused by brain damage from bilirubin toxicity. Dystonia is one of the most debilitating symptoms of kernicterus and results from damage to the globus pallidus (GP).
Fu-Chen Yang, Jay L. Vivian, Catherine Traxler, Steven M. Shapiro, John A. Stanford   +4 more
doaj   +1 more source