Results 21 to 30 of about 215,346 (265)

Celecoxib Exerts Neuroprotective Effects in β-Amyloid-Treated SH-SY5Y Cells Through the Regulation of Heme Oxygenase-1: Novel Insights for an Old Drug

Frontiers in Cell and Developmental Biology, 2020
The formation and aggregation of amyloid-β-peptide (Aβ) into soluble and insoluble species represent the pathological hallmarks of Alzheimer’s disease (AD).
Emanuela Mhillaj, Massimiliano Papi, Massimiliano Papi, Fabiola Paciello, Fabiola Paciello, Andrea Silvestrini, Andrea Silvestrini, Rolando Rolesi, Rolando Rolesi, Valentina Palmieri, Valentina Palmieri, Giordano Perini, Giordano Perini, Anna Rita Fetoni, Anna Rita Fetoni, Luigia Trabace, Cesare Mancuso, Cesare Mancuso   +17 more
doaj   +1 more source

Detection of Compound Heterozygous Sickle Cell-b+ Thalassaemia in a Patient with Extreme Weakness, Mild Jaundice and Moderate Anaemia - A Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2017
A 16-year-old female complained of extreme weakness. She had moderate anaemia; her Haemoglobin (Hb) was 7.7 gm/dl. Peripheral blood smear showed few sickled red cells. Sickle cell test was positive. High-Performance Liquid Chromatography (HPLC) revealed
Subhash Chandra, Mostafa Ali, Pooja Mishra, Ashok Kumar Kapoor, Yamini Jindal   +4 more
doaj   +1 more source

Direct Bilirubin Levels Predict Long-Term Outcomes in Patients With Acute Coronary Syndrome Under Different Glucose Metabolism Status: A 6.5-Year Cohort Study of Three-Vessel Disease

Frontiers in Cardiovascular Medicine, 2021
Background: There is controversy over the relationship between bilirubin and coronary artery disease. This study aimed to evaluate the predictive value of direct bilirubin (DB) in patients with complex acute coronary syndrome (ACS).Methods: From April ...
Yue Liu, Ce Zhang, Lin Jiang, Jian Tian, Xue-yan Zhao, Jing-jing Xu, Ru Liu, Bo Xu, Ru-tai Hui, Run-lin Gao, Jin-qing Yuan, Lian-jun Xu, Lei Song   +12 more
doaj   +1 more source

Association Between Serum Bilirubin and the Progression of Carotid Atherosclerosis in Type 2 Diabetes

Journal of Lipid and Atherosclerosis, 2020
Objective: This study investigated whether serum bilirubin levels can predict the progression of carotid atherosclerosis in individuals with type 2 diabetes mellitus (T2DM).
Inkuk Lee, Hyeok-Hee Lee, Yongin Cho, Young Ju Choi, Byung Wook Huh, Byung-Wan Lee, Eun Seok Kang, Seok Won Park, Bong-Soo Cha, Eun Jig Lee, Yong-ho Lee, Kap Bum Huh   +11 more
doaj   +1 more source

Gilbert’s Syndrome and the Gut Microbiota – Insights From the Case-Control BILIHEALTH Study

Frontiers in Cellular and Infection Microbiology, 2021
The heme catabolite bilirubin has anti-inflammatory, anti-oxidative and anti-mutagenic effects and its relation to colorectal cancer (CRC) risk is currently under evaluation.
Patrick A. Zöhrer, Patrick A. Zöhrer, Claudia A. Hana, Nazlisadat Seyed Khoei, Nazlisadat Seyed Khoei, Christine Mölzer, Marlies Hörmann-Wallner, Anela Tosevska, Anela Tosevska, Anela Tosevska, Daniel Doberer, Rodrig Marculescu, Andrew C. Bulmer, Craig W. Herbold, David Berry, David Berry, Karl-Heinz Wagner, Karl-Heinz Wagner   +17 more
doaj   +1 more source

Bilirubin–Albumin Binding and Free Bilirubin [PDF]

Journal of Perinatology, 2001
The relevance of plasma bilirubin-albumin binding and, in particular, the nonalbumin-bound or "free" bilirubin concentration to neonatal bilirubin toxicity is controversial. The pivotal role that "free" bilirubin played in the bilirubin toxicity that occurred following administration of sulfisoxazole or benzyl alcohol to jaundiced newborns, and the ...
openaire   +2 more sources

Inhibition of Lipid Accumulation in Skeletal Muscle and Liver Cells: A Protective Mechanism of Bilirubin Against Diabetes Mellitus Type 2

Frontiers in Pharmacology, 2021
Ectopic lipid accumulation in skeletal muscle and liver drives the pathogenesis of diabetes mellitus type 2 (DMT2). Mild hyperbilirubinaemia has been repeatedly suggested to play a role in the prevention of DMT2 and is known for its capacity to shape an ...
Claudia A. Hana, Eva-Maria Klebermass, Theresa Balber, Theresa Balber, Markus Mitterhauser, Markus Mitterhauser, Ruth Quint, Yvonne Hirtl, Antonia Klimpke, Sophie Somloi, Juliana Hutz, Elisabeth Sperr, Paulina Eder, Jana Jašprová, Petra Valášková, Libor Vítek, Libor Vítek, Elke Heiss, Karl-Heinz Wagner   +18 more
doaj   +1 more source

Micro-Raman Spectroscopy Analysis of Optically Trapped Erythrocytes in Jaundice

Frontiers in Physiology, 2020
Derangements in bilirubin metabolism and/or dysfunctions in the hepato-biliary system lead to the unhealthy buildup of bilirubin in blood, resulting in jaundice.
Sanu Susan Jacob, Aseefhali Bankapur, Surekha Barkur, Mahendra Acharya, Santhosh Chidangil, Pragna Rao, Asha Kamath, R. Vani Lakshmi, Prathap M. Baby, Raghavendra K. Rao   +9 more
doaj   +1 more source

Evaluation of simple antioxidant blood parameters in patients with migraine

Frontiers in Neurology, 2022
BackgroundThe study aims to investigate the role of serum albumin (ALB) and creatinine (CRE), bilirubin (BIL), and uric acid (UA) as major intravascular antioxidants in migraine.MethodsWe enrolled 148 patients with migraine and 150 age- and sex-matched ...
Zhenzhen Yang, Pengfei Xu, Chaofan Geng, Hongju Zhang   +3 more
doaj   +1 more source

Application of the ALBI Scoring System for Mortality Outcome Prediction in Patients with Hypertrophic Cardiomyopathy

Global Heart, 2022
Background: There is no information about the clinical significance of the albumin-bilirubin (ALBI) score in patients with hypertrophic cardiomyopathy (HCM).
Ping Qiao, Liying Li, Haiyan Ruan, Muxin Zhang, Ziqiong Wang, Xinran Li, Rufeng Shi, Xin Wei, Linjia Duan, Yi Zheng, Sen He   +10 more
doaj   +1 more source