Results 41 to 50 of about 57,539 (299)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

The frequency, clinical course, and health related quality of life in adults with Gilbert’s syndrome: a longitudinal study

BMC Gastroenterology, 2019
Background Gilbert syndrome (GS) is an autosomal recessive inherited disorder of bilirubin glucuronidation which has not been investigated in Egypt. This longitudinal study investigated the frequency, clinical course, genetic profile and health related ...
Sanaa Kamal, Sara Abdelhakam, Dalia Ghoraba, Yasmin Massoud, Kareem Abdel Aziz, Huda Hassan, Tamer Hafez, Ahmed Abdel Sallam   +7 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Gilbert Disease (With Respect to a case)

Eurasian Journal of Medicine, 2019
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Ahmet Yıldız, Hasan Gök, Arif Yılmaz, Lütfi Gökmen   +3 more
doaj  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Bilineal inheritance of PKD1 abnormalities mimicking autosomal recessive polycystic disease

, 2013
BACKGROUND: Dominant polycystic kidney disease is common and usually presents clinically in adulthood. Recessive polycystic kidney disease is much less common and frequently presents antenatally or in the neonatal period with severe renal involvement ...
Sukhtankar, Priya, Gilbert, Rodney D., Fowler, Darren J., Lachlan, Katherine   +3 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Mapping of infection prevention and control education and training in some countries of the World Health Organization’s Eastern Mediterranean Region: current situation and future needs

Antimicrobial Resistance and Infection Control, 2023
Background A strong understanding of infection prevention and control (IPC) procedures and comprehensive training among healthcare workers is essential for effective IPC programs.
Rima Moghnieh, Amal Saif Al-Maani, Jana Berro, Nour Ibrahim, Rana Attieh, Dania Abdallah, Jameela Al-Ajmi, Dhouha Hamdani, Najiba Abdulrazzaq, Abeer Omar, Safa Al-Khawaja, Rami Al-Abadla, Salam Al-Ratrout, Mohammad Gharaibeh, Zakaria Abdelrahim, Hiba Azrag, Karima Mayar Amiri, Atika Berry, Bashar Hagali, Jamal Kadhim, Huda Al-Shami, Mumtaz Ali Khan, Roula Husni, Iman Heweidy, Bassim Zayed   +24 more
doaj   +1 more source

[Gilbert's disease].

Boletin medico del Hospital Infantil de Mexico, 1981
An extensive review of Gilbert's disease (unconjugated, non-hemolytic hyperbilirubinemia) is made with incidence not exactly determined, but it is a disease linked to hereditary factors. Two types of the disease, together with the controversy existing as to their pathogenesis are discussed. The clinical picture and all laboratory studies carried out to
M, Shein, S, Pick
openaire   +1 more source

ELECTRON MICROSCOPIC OBSERVATION OF THE LIVER IN GILBERT'S DISEASE

The Kurume Medical Journal, 1965
The term “Gilbert's disease” is today applied to a heterogenous group of benigndisorder, which is characterized by low-grade chronic unconjugated hyperbilirubinemia not due to overt hemolysis.Recently much attention has been paid to this disorder because it offers clues as to the mechanism of jaundice or bilirubin metabolism.
TANIKAWA, KYUICHI, EMURA, TAKESHI
openaire   +3 more sources