Effect of bilirubin and Gilbert syndrome on health: cohort analysis of observational, genetic, and Mendelian randomisation associations [PDF]
BMJ Medicine, 2023 Objectives To compare associations between the Gilbert syndrome genotype in European populations, measured bilirubin concentrations, genetically predicted bilirubin using this genotype, and a wide range of health outcomes in a large cohort.Design Cohort ...
Willie Hamilton +3 more
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Effects of Gilbert syndrome on cardiovascular disease risk reduction: a systematic review [PDF]
The Egyptian Heart JournalBackground Gilbert syndrome is a human genetic disorder which affects bilirubin metabolism in the liver and results in unconjugated hyperbilirubinemia.
Nicola Churchill +2 more
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Genetic testing of UGT1A1 in the diagnosis of Gilbert syndrome: The discovery of seven novel variants in the Chinese population [PDF]
Molecular Genetics & Genomic Medicine, 2022 Background Genetic testing of UGT1A1 was used to facilitate the diagnosis of Gilbert syndrome, and analyze the distribution features of pathogenic variants in the Chinese population.
Leilei Gu +4 more
doaj +2 more sources
Case Report: Persistent indirect hyperbilirubinemia caused by Gilbert syndrome misdiagnosed as drug-induced liver injury during tuberculosis treatment [PDF]
Frontiers in MedicineBackgroundDrug-induced liver injury (DILI) is a common complication of anti-tuberculosis therapy and frequently leads to treatment interruption or modification.
Ping Liu, Yuming Xu
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Patients with Gilbert syndrome and type 2 diabetes have lower prevalence of microvascular complications [PDF]
Metabolism Open, 2021 Objective: Accumulating clinical evidence indicates an inverse relationship between oxidative stress and unconjugated hyperbilirubinemia. This study aimed to compare the prevalence of diabetes microvascular complications in patients with Gilbert syndrome
Ana Cecilia Uribe-Weichers +3 more
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A Case Report of Gilbert Syndrome Presenting With Acute Cholecystitis [PDF]
Clinical Case ReportsA 38‐year‐old male with Gilbert syndrome presented with acute cholecystitis, jaundice, and elevated liver enzymes. This case highlights the importance of genetic testing for unexplained jaundice, avoiding misdiagnosis, and guiding personalized treatment ...
Shu‐Qi Yang +6 more
doaj +2 more sources
Case Report: Hyperbilirubinemia in Gilbert Syndrome Attenuates Covid-19-Induced Metabolic Disturbances [PDF]
Frontiers in Cardiovascular Medicine, 2021 Gilbert syndrome (GS) is a liver disorder characterized by non-hemolytic unconjugated hyperbilirubinemia. On the other hand, Coronavirus disease 2019 (Covid-19) is a recent viral infectious disease presented as clusters of pneumonia, triggered by the ...
Hayder M. Al-kuraishy +6 more
doaj +2 more sources
An Epileptic Patient with Recurrent Hyperbilirubinemia Caused by Gilbert Syndrome [PDF]
Case Reports in Gastroenterology, 2020 Gilbert syndrome (GS) is characterized by intermittent indirect bilirubin elevation. Several antiepileptic drugs (AEDs) impair the liver function to different degrees, such as valproic acid, lamotrigine, phenobarbital, phenytoin, and carbamazepine ...
Yaoyao Zhang +5 more
doaj +2 more sources
Tolvaptan-induced isolated elevation of bilirubin in a patient with Gilbert syndrome [PDF]
SAGE Open Medical Case Reports, 2023 Tolvaptan is the current standard of treatment for autosomal dominant polycystic kidney disease. It operates by acting on V2 receptors and blocks vasopressin interactions, causing a reduction in the rate of renal cyst growth and preserving kidney ...
Matthew Nguyen +4 more
doaj +2 more sources
Rethinking hyperbilirubinemia: Gilbert syndrome in children with cystic fibrosis, a case report [PDF]
Respiratory Medicine Case ReportsCystic Fibrosis leads to liver complications, including cystic fibrosis liver disease but hyperbilirubinemia in CF patients on CFTR modulators is less understood.
Yara Salameh, John Lyles, Shatha Yousef
doaj +2 more sources