Results 1 to 10 of about 22,737 (234)
Apalutamide treatment and refractory hypothyroidism: effects of apalutamide on levothyroxine metabolism [PDF]
European Thyroid JournalApalutamide, a selective androgen receptor antagonist, is a new treatment for prostate cancer. Among the side effects observed during apalutamide treatment, an increased risk of hypothyroidism has been reported, particularly in patients previously ...
Florie Quattrochi +2 more
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Development and characterization of near-isogenic lines for quantitative trait locus qDT.3B.1 underlying drought tolerance in wheat. [PDF]
Plant GenomeAbstract Drought is a critical challenge to wheat (Triticum aestivum L.) productivity. The quantitative complexity of drought tolerance makes breeding for this trait difficult. Developing near‐isogenic lines (NILs) targeting quantitative trait locus (QTL) for 1000‐grain weight (TGW) under drought stress can effectively identify key mechanisms and genes.
Caguiat JD +4 more
europepmc +2 more sources
The Effect of Uridine Diphosphate‐Glucuronosyltransferase Inhibition on the Pharmacokinetics of Ecopipam and Its Metabolites [PDF]
Clinical and Translational ScienceEcopipam, a selective dopamine D1 receptor antagonist in development for Tourette syndrome, is primarily converted by uridine diphosphate‐glucuronosyltransferase (UGT)1A9 to ecopipam glucuronide, with a minor metabolic pathway by cytochrome P450 3A4 ...
Virginia D. Schmith +3 more
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Dexamethasone-Mediated Regulation of CYP3A4 and UGTs in Human Hepatoma HuH-7 Cells. [PDF]
Fundam Clin PharmacolABSTRACT Background The application of human hepatic cell lines to early drug discovery and development instead of human primary hepatocytes (HPHs) has been limited because of the low level of drug‐metabolizing enzymes (DMEs). Objective The study aimed to evaluate the effects of dexamethasone (DEX) treatment on DME expression, activities, and ...
Yu H, Lee SH, Kim JH, Kim SJ, Kang HE.
europepmc +2 more sources
Liver Transplantation in a Patient with Crigler-Najjar Syndrome Type 1: A Case Report of Two Cases
Archives of Anesthesia and Critical Care, 2023 Crigler Najjar syndrome(CNS); is a disease in which the diphosphate glucuronosyltransferase (bilirubin-UGT) enzyme function, which plays a role in the glucuronidation of bilirubin, is deficient as a result of mutation in the uridine 5'-diphosphate ...
Ahmed Uslu +3 more
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PLoS ONE, 2021 Previous studies have revealed that gypenosides produced from Gynostemma pentaphyllum (Thunb.) Makino are mainly dammarane-type triterpenoid saponins with diverse structures and important biological activities, but the mechanism of diversity for ...
Yangmei Zhang +8 more
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Pharmacokinetics and Pharmacogenetics of Dabigatran
Рациональная фармакотерапия в кардиологии, 2021 Dabigatran etexilate is a prodrug of dabigatran, a oral direct inhibitor of thrombin. Pharmacokinetics of dabigatran etexilate doesn’t have the disadvantages of vitamin K antagonists.
A. V. Savinova +4 more
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Archives of Anesthesia and Critical Care, 2022 Inherited defects of Uridine 5'-diphospho-glucuronosyltransferase (UDPGT) can cause congenital unconjugated hyperbilirubinemia. The perioperative anesthetic management of such patients poses several challenges.
Amit Kumar +3 more
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Quantitative analysis of the UDP‐glucuronosyltransferase transcriptome in human tissues
Pharmacology Research & Perspectives, 2023 UDP‐glucuronosyltransferases (UGTs) are phase II drug metabolizing enzymes that play important roles in the detoxification of endogenous and exogenous substrates.
Lucas Zhou +3 more
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Фундаментальная и клиническая медицина, 2020 Aim. To explore allele and genotype frequencies of the rs8175347 polymorphism within the UGT1A1 gene in Kemerovo Region. Materials and Methods. The study sample included 64 male and 68 female inhabitants of the Kemerovo Region.
A. N. Volkov
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