Results 21 to 30 of about 22,737 (234)

Enhanced Characterization of Drug Metabolism and the Influence of the Intestinal Microbiome: A Pharmacokinetic, Microbiome, and Untargeted Metabolomics Study. [PDF]

, 2020
Determining factors that contribute to interindividual and intra-individual variability in pharmacokinetics (PKs) and drug metabolism is essential for the optimal use of drugs in humans.
Alhaja, Maher, Dorrestein, Pieter C, Jarmusch, Alan K, Knight, Rob, Liyanage, Marlon, Ma, Joseph D, Momper, Jeremiah D, Tsunoda, Shirley M, Vrbanac, Alison   +8 more
core   +1 more source

Development of icterus gravis in a preterm infant with G71R UGT1A1 polymorphism [PDF]

, 2013
BACKGROUND: Uridine diphosphate-glucuronosyltransferase (UGT) gene family is involved in the detoxification of biomaterials and drugs in the liver. Among the UGT gene family members, only UGT1A1 is involved in bilirubin conjugation.
Akimune Kaga, Haruo Usuda, Muneyuki Tanabu, Sachiko Saito, Shigeo Kure, Susumu Kanda, Takuma Matsuki, Yohei Watanabe, Yukimune Ohkubo, Yutaka Suzuki   +9 more
core   +1 more source

Effects of dietary components on testosterone metabolism via UDP‐glucuronosyltransferase (UGT)

Frontiers in Endocrinology, 2013
The potential interference in testosterone metabolism through ingested substances has ramifications for: i) a range of pathologies such as prostate cancer, ii) medication contra-indications, iii) disruption to the endocrine system, and iv) potential ...
Carl eJenkinson, Andrea ePetroczi, Declan P Naughton   +2 more
doaj   +1 more source

Strong Inhibition of Celastrol Towards UDP-Glucuronosyl Transferase (UGT) 1A6 and 2B7 Indicating Potential Risk of UGT-Based Herb-Drug Interaction

Molecules, 2012
Celastrol, a quinone methide triterpene isolated from <em>Tripterygium wilfordii</em> Hook F., has various biochemical and pharmacological activities, and is now being developed as a promising anti-tumor agent.
Qi Wang, Ru-Meng Ma, Jian-Ping Deng, Gang Li, Liang Wang, Jun Yuan, Yong-Sheng Zhang, Xing-Chun Gao, Yan-Yang Tu   +8 more
doaj   +1 more source

Performance of in silico tools for the evaluation of UGT1A1 missense variants [PDF]

, 2015
Variations in the gene encoding uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) are particularly important because they have been associated with hyperbilirubinemia in Gilbert’s and Crigler–Najjar syndromes as well as with changes in drug ...
Bronze-da-Rocha, Elsa, Costa, Elísio, Rodrigues, Carina, Santos-Silva, Alice   +3 more
core   +1 more source

Metabolism of 2,3-Dehydrosilybin A and 2,3-Dehydrosilybin B: A Study with Human Hepatocytes and Recombinant UDP-Glucuronosyltransferases and Sulfotransferases

Antioxidants, 2021
2,3-Dehydrosilybin A and 2,3-dehydrosilybin B are a pair of enantiomers formed by the oxidation of the natural flavonolignans silybin A and silybin B, respectively.
Jiří Vrba, Barbora Papoušková, Kateřina Lněničková, Pavel Kosina, Vladimír Křen, Jitka Ulrichová   +5 more
doaj   +1 more source

A Network-Based Pharmacology Study of the Herb-Induced Liver Injury Potential of Traditional Hepatoprotective Chinese Herbal Medicines [PDF]

, 2017
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Cheung, F, Feng, Y, HONG, M, Huang, J, LI, S, Tan, HY, Wang, N   +6 more
core   +1 more source

Analysis of the UDP-glucuronosyltransferase gene in Portuguese patients with a clinical diagnosis of Gilbert and Crigler–Najjar syndromes [PDF]

, 2006
We describe the molecular study in a cohort of 120 Portuguese patients with the clinical diagnosis of Gilbert syndrome and in one with the diagnosis of Crigler–Najjar syndrome type II, as well as a prenatal diagnosis of Crigler–Najjar syndrome type I ...
Barbot, José, Bauerle, Roswitha, Cancela, Eugénia, Carvalho, João, Costa, Elísio, Costa, Miguel, Freitas, Teresa, Martins, Marcia, Santos, Rosário, Santos-Silva, Ermelinda, Saraiva, Jorge, Vieira, Emília   +11 more
core   +1 more source

A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. [PDF]

, 2010
We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which ...
Aben, Katja K, Albanes, Demetrius, Allen, Naomi E, Allione, Alessandra, Andriole, Gerald, Baris, Dalsu, Benhamou, Simone, Besenbacher, Soren, Bishop, David T, Black, Amanda, Bolick, Sophia CE, Brennan, Paul, Bueno-de-Mesquita, H Bas, Burdett, Laurie, Cancel-Tassin, Geraldine, Canzian, Federico, Caporaso, Neil, Carrato, Alfredo, Chanock, Stephen J, Chatterjee, Nilanjan, Chen, Meng, Clavel-Chapelon, Francoise, Cortessis, Victoria K, Cussenot, Olivier, Czerniak, Bogdan, D García-Prats, María, De Vivo, Immaculata, Dietrich, Holger, Dinney, Colin P, Diver, W Ryan, Figueroa, Jonine D, Fletcher, Tony, Fraumeni, Joseph F, Fu, Yi-Ping, Gago-Dominguez, Manuela, Gapstur, Susan M, Garcia-Closas, Montserrat, García-Closas, Reina, Godfrey, Ashley, Golka, Klaus, Grubb, Robert, Guarrera, Simonetta, Gurzau, Eugen, Hengstler, Jan G, Hildebrandt, Michelle AT, Hoover, Robert N, Hunter, David J, Hutchinson, Amy, Jacobs, Eric J, Jacobs, Kevin B, Johnson, Alison, Karagas, Margaret R, Kiemeney, Lambertus A, Kiltie, Anne E, Knowles, Margaret A, Kogevinas, Manolis, Koppova, Kvetoslava, Kumar, Rajiv, Landi, Maria Teresa, Ljungberg, Borje, Lloreta, Josep, Makkinje, Remco R, Malats, Nuria, Matullo, Giuseppe, Mayordomo, Jose I, McGrath, Monica, Navarro, Carmen, Panico, Salvatore, Pike, Malcolm C, Polidoro, Silvia, Porru, Stefano, Prokunina-Olsson, Ludmila, Purdue, Mark P, Rafnar, Thorunn, Real, Francisco X, Riboli, Elio, Ricceri, Fulvio, Rothman, Nathaniel, Rudnai, Peter, Sacerdote, Carlotta, Sanchez, Manuel, Sanz-Velez, José I, Schned, Alan, Schwenn, Molly, Selinski, Silvia, Serra, Consol, Silverman, Debra T, Stefansson, Kari, Stern, Mariana C, Sulem, Patrick, Tardón, Adonina, Taylor, Jack A, Teo, Mark TW, Thun, Michael, Tjonneland, Anne, Trichopoulos, Dimitrios, Valdivia, Gabriel, Van Den Berg, David, Vermeulen, Sita H, Vineis, Paolo, Virtamo, Jarmo, Wang, Zhaoming, Weinstein, Stephanie J, Wheeler, William, Witjes, J Alfred, Wu, Xifeng, Xu, Zongli, Yang, Hushan, Yeager, Meredith, Yuan, Jian-Min   +109 more
core   +2 more sources

Effect of UDP‐glucuronosyltransferase 1A1 activity on risk for developing Gilbert's syndrome

Kaohsiung Journal of Medical Sciences, 2019
Variations at the six nucleotides −3279 (T > G), −53 (A[TA]6TAA > A[TA]7TAA), 211 (G > A), 686 (C > A), 1091 (C > T), and 1456 (T > G) in the UDP‐glucuronosyltransferase 1A1 (UGT1A1) gene were determined in 178 Taiwanese patients with Gilbert's syndrome ...
May‐Jen Huang, Yi‐Chun Chen, Yang‐Yang Huang, Sien‐Sing Yang, Pei‐Lain Chen, Ching‐Shan Huang   +5 more
doaj   +1 more source