Results 11 to 20 of about 12,220 (202)
Apalutamide treatment and refractory hypothyroidism: effects of apalutamide on levothyroxine metabolism [PDF]
European Thyroid JournalApalutamide, a selective androgen receptor antagonist, is a new treatment for prostate cancer. Among the side effects observed during apalutamide treatment, an increased risk of hypothyroidism has been reported, particularly in patients previously ...
Florie Quattrochi +2 more
doaj +2 more sources
Piscine UDP-glucuronosyltransferase 1B [PDF]
Aquatic Toxicology, 2007 Glucuronidation is an important detoxification pathway for organic pollutants in fish. We report here the isolation and characterisation of UDP-glucuronosyltransferases (UGT) genes from the closely related marine flatfish, plaice (Pleuronectes platessa) and flounder (Platichthys flesus).
Michael Leaver
exaly +4 more sources
The Effect of Uridine Diphosphate‐Glucuronosyltransferase Inhibition on the Pharmacokinetics of Ecopipam and Its Metabolites [PDF]
Clinical and Translational ScienceEcopipam, a selective dopamine D1 receptor antagonist in development for Tourette syndrome, is primarily converted by uridine diphosphate‐glucuronosyltransferase (UGT)1A9 to ecopipam glucuronide, with a minor metabolic pathway by cytochrome P450 3A4 ...
Virginia D. Schmith +3 more
doaj +2 more sources
Age-Dependent Hepatic UDP-Glucuronosyltransferase Gene Expression and Activity in Children
Frontiers in Pharmacology, 2016 UDP-glucuronosyltransferases (UGTs) are important phase II drug metabolism enzymes. The aim of this study was to explore the relationship between age and changes in mRNA expression and activity of major human hepatic UGTs, as well as to understand the ...
Huma Mehboob, Wanqing Liu
exaly +3 more sources
PLoS ONE, 2021 Previous studies have revealed that gypenosides produced from Gynostemma pentaphyllum (Thunb.) Makino are mainly dammarane-type triterpenoid saponins with diverse structures and important biological activities, but the mechanism of diversity for ...
Yangmei Zhang +8 more
doaj +2 more sources
Liver Transplantation in a Patient with Crigler-Najjar Syndrome Type 1: A Case Report of Two Cases
Archives of Anesthesia and Critical Care, 2023 Crigler Najjar syndrome(CNS); is a disease in which the diphosphate glucuronosyltransferase (bilirubin-UGT) enzyme function, which plays a role in the glucuronidation of bilirubin, is deficient as a result of mutation in the uridine 5'-diphosphate ...
Ahmed Uslu +3 more
doaj +1 more source
Pharmacokinetics and Pharmacogenetics of Dabigatran
Рациональная фармакотерапия в кардиологии, 2021 Dabigatran etexilate is a prodrug of dabigatran, a oral direct inhibitor of thrombin. Pharmacokinetics of dabigatran etexilate doesn’t have the disadvantages of vitamin K antagonists.
A. V. Savinova +4 more
doaj +1 more source
Archives of Anesthesia and Critical Care, 2022 Inherited defects of Uridine 5'-diphospho-glucuronosyltransferase (UDPGT) can cause congenital unconjugated hyperbilirubinemia. The perioperative anesthetic management of such patients poses several challenges.
Amit Kumar +3 more
doaj +1 more source
Quantitative analysis of the UDP‐glucuronosyltransferase transcriptome in human tissues
Pharmacology Research & Perspectives, 2023 UDP‐glucuronosyltransferases (UGTs) are phase II drug metabolizing enzymes that play important roles in the detoxification of endogenous and exogenous substrates.
Lucas Zhou +3 more
doaj +1 more source
Фундаментальная и клиническая медицина, 2020 Aim. To explore allele and genotype frequencies of the rs8175347 polymorphism within the UGT1A1 gene in Kemerovo Region. Materials and Methods. The study sample included 64 male and 68 female inhabitants of the Kemerovo Region.
A. N. Volkov
doaj +1 more source