Results 1 to 10 of about 56,416 (247)
Systematic characterization of lysine glucuronidation in a bispecific antibody [PDF]
mAbsThis study presents a systematic characterization of lysine glucuronidation that was revealed during the charge variant characterization of a bispecific antibody (bsAb).
Michael R. Reyda +7 more
doaj +2 more sources
Glucuronidation: driving factors and their impact on glucuronide disposition
Drug Metabolism Reviews, 2017 Glucuronidation is a well-recognized phase II metabolic pathway for a variety of chemicals including drugs and endogenous substances. Although it is usually the secondary metabolic pathway for a compound preceded by phase I hydroxylation, glucuronidation alone could serve as the dominant metabolic pathway for many compounds, including some with high ...
Shufan Ge, Rashim Singh, Dr. Sumit Basu
exaly +4 more sources
Frontiers in Pharmacology, 2022 Glucuronidation catalyzed by UDP-glucuronosyltransferases (UGTs) is one of the most important phase II mechanisms, facilitating drug clearance via conjugation of glucuronic acid with polar groups of xenobiotics.
Wanying Zeng +9 more
doaj +1 more source
Variation in trans-3'-hydroxycotinine glucuronidation does not alter the nicotine metabolite ratio or nicotine intake. [PDF]
PLoS ONE, 2013 CYP2A6 metabolizes nicotine to its primary metabolite cotinine and also mediates the metabolism of cotinine to trans-3'-hydroxycotinine (3HC). The ratio of 3HC to cotinine (the "nicotine metabolite ratio", NMR) is an in vivo marker for the rate of CYP2A6
Andy Z X Zhu +5 more
doaj +1 more source
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 2012 Alcohol is associated with significant morbidity and mortality. Subjects abusing alcohol can be identified through clinical history, examination or self-report questionnaires. A range of biomarkers is available for detecting alcohol misuse, but there is still a need for a marker that can detect alcohol consumption in the time window between one day ...
Walsham, Natalie E., Sherwood, Roy
openaire +3 more sources
UGT1A1 and UGT1A9 Are Responsible for Phase II Metabolism of Tectorigenin and Irigenin In Vitro
Molecules, 2022 Tectorigenin and irigenin are biologically active isoflavones of Belamcanda chinensis (L.) DC. Previous studies indicated that both compounds could be metabolized in vivo; however, the kinetic parameters of enzymes involved in the metabolization of ...
Ji Li, Zhangyao Xu, Jifeng Gu
doaj +1 more source
Potential Assessment of UGT2B17 Inhibition by Salicylic Acid in Human Supersomes In Vitro
Molecules, 2021 Glucuronidation is a Phase 2 metabolic pathway responsible for the metabolism and excretion of testosterone to a conjugate testosterone glucuronide.
Hassan Salhab +2 more
doaj +1 more source
Profiling of Urinary Glucuronidated Bile Acids across Age Groups
Metabolites, 2022 We investigated the age-dependent changes in urinary excretion of glucuronidated bile acids at the C-3 position. Bile acid 3-glucuronides accounted for 0.5% of urinary bile acids in neonates, and the proportion of bile acid 3-glucuronides plateaued at 1 ...
Yamato Muto +6 more
doaj +1 more source
Importance of Ethnicity, CYP2B6 and ABCB1 Genotype for Efavirenz Pharmacokinetics and Treatment Outcomes: A Parallel-group Prospective Cohort Study in two sub-Saharan Africa Populations. [PDF]
, 2013 We evaluated the importance of ethnicity and pharmacogenetic variations in determining efavirenz pharmacokinetics, auto-induction and immunological outcomes in two African populations. ART naïve HIV patients from Ethiopia (n = 285) and Tanzania (n = 209)
A Habtewold +48 more
core +7 more sources
Molecules, 2023 Propranolol, a non-selective beta-blocker medication, has been utilized in the treatment of cardiovascular diseases for several decades. Its hydroxynaphthyl metabolites have been recognized to possess varying degrees of beta-blocker activity due to the ...
Fan Yang +3 more
doaj +1 more source