Results 21 to 30 of about 42,461 (214)
UGT2B7 c.-161C>T polymorphism frequency in Croatian population
Arhiv za Higijenu Rada i Toksikologiju, 2022 Uridine diphosphate glucuronosyltransferase-2B7 (UGT2B7), enzyme responsible for the elimination of a number of xenobiotics through glucuronidation, is expressed in the gut, kidneys, intestines, and brain.
Božina Tamara +6 more
doaj +1 more source
PLoS ONE, 2013 UnlabelledBelinostat is a hydroxamate class HDAC inhibitor that has demonstrated activity in peripheral T-cell lymphoma and is undergoing clinical trials for non-hematologic malignancies.
Ling-Zhi Wang +16 more
doaj +1 more source
Bidirectional interactions between indomethacin and the murine intestinal microbiota
eLife, 2015 The vertebrate gut microbiota have been implicated in the metabolism of xenobiotic compounds, motivating studies of microbe-driven metabolism of clinically important drugs.
Xue Liang +5 more
doaj +1 more source
Clinical Pharmacology of Paracetamol in Neonates: A Review
Current Therapeutic Research, 2015 Paracetamol is commonly used to control mild-to-moderate pain or to reduce opioid exposure as part of multimodal analgesia, and is the only compound recommended to treat fever in neonates.
Gian Maria Pacifici, MD, PhD +1 more
doaj +1 more source
The Evaluation of Genetic Profiles of UGT1A4 and UGT1A6 in the Turkish Population
Journal of Contemporary Medicine, 2021 Aim: Uridine diphosphate glucuronosyltransferases (UGTs) are a superfamily of conjugation phase II enzymes and is responsible for catalyzing the glucuronidation of many endobiotic or xenobiotic substrates.
Zuhal Uçkun Şahinoğulları
doaj +1 more source
The radioimmunoassay of steroid glucuronides. The oestrogen C-3 glucuronides as haptens [PDF]
Biochemical Journal, 1975 Antisera were prepared against three related oestrogen ring-A glucuronides, oestrone 3-glucuronide, oestradiol 3-glucuronide and oestriol 3-glucuronide. The corresponding 6,7-3H-labelled conjugates were synthesized as radioligands and the cross-reactions of the antisera against ring-A oestrogen glucuronides and other steroid conjugates were examined ...
P, Samarajeewa, A E, Kellie
openaire +2 more sources
The Antidiabetic Potential of Alpha‐Mangostin: A Review of Preclinical and Clinical Evidence
AgriFood: Journal of Agricultural Products for Food, EarlyView.Alpha‐mangostin is a compound from the pericarp of Garcinia mangostana. The antidiabetic effects of alpha‐mangostin include enhancing insulin secretion, improving glucose uptake through GLUT receptor upregulation, reducing oxidative stress and inflammation, promoting wound healing, reducing HbA1C, reducing HOMA‐IR index, and decreased mRNA expressions ...
Oliver Dean John +4 more
wiley +1 more source
Animal Research and One Health, EarlyView.This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen +2 more
wiley +1 more source
Cells, 2022 Prostate cancer (PCa) is the second most diagnosed cancer in the United States and is associated with metabolic reprogramming and significant disparities in clinical outcomes among African American (AA) men. While the cause is likely multi-factorial, the
Anindita Ravindran +23 more
doaj +1 more source
Codeine toxicity via breast Milk: Can this occur and implications for opiate therapy in children
British Journal of Clinical Pharmacology, EarlyView.Codeine is commonly used in combination analgesic products. The use of codeine during breastfeeding can rarely be associated with serious adverse effects related to genetic polymorphisms affecting codeine's metabolism and disposition. Clinicians treating infants of breastfeeding mothers should be aware of this rare but potentially serious complication.
Michael Rieder
wiley +1 more source