Results 21 to 30 of about 49,196 (193)

Inhibitory Effects of Baicalein Derived from Japanese Traditional Herbal Medicine on SN-38 Glucuronidation

Journal of Pharmacy & Pharmaceutical Sciences, 2018
Purpose: The chemotherapeutic agent irinotecan is hydrolyzed to its active form SN-38 by human carboxyesterases, but SN-38 is converted into the inactive form SN-38G by hepatic UDP-glucuronosyltransferases (UGTs).
Takashi Satoh, Ayaka Igarashi, Misaki Tanno, Koki Yamada, Natsuko Takahashi-Suzuki, Kazuhiro Watanabe   +5 more
doaj   +1 more source

Maternal Nutrient Restriction Disrupts Gene Expression and Metabolites Associated with Urea Cycle, Steroid Synthesis, Glucose Homeostasis, and Glucuronidation in Fetal Calf Liver

Metabolites, 2022
This study aimed to understand the mechanisms underlying the effects of maternal undernutrition (MUN) on liver growth and metabolism in Japanese Black fetal calves (8.5 months in utero) using an approach that integrates metabolomics and transcriptomics ...
Susumu Muroya, Yi Zhang, Kounosuke Otomaru, Kazunaga Oshima, Ichiro Oshima, Mitsue Sano, Sanggun Roh, Koichi Ojima, Takafumi Gotoh   +8 more
doaj   +1 more source

a. Glucuronidation pathway analysis.

, 2023
BackgroundThe etiology of autism spectrum (ASD) and Attention Deficit/Hyperactivity (ADHD) disorders are multifactorial. Epidemiological studies have shown associations with environmental pollutants, such as plasticizers.
Robert A. Steer (16979607), Margaret D. Schluter (16979604), T. Peter Stein (2016349), Xue Ming (2016343)   +3 more
core   +1 more source

Implication of human UGT2B7, 2B15 and 2B17 in 19-norandrosterone metabolism

Frontiers in Endocrinology, 2013
Nandrolone (19-nortestosterone) is an anabolic androgenic steroid commonly abused for doping purposes. Nandrolone is mainly metabolized in the liver into 19-norandrosterone prior to glucuronidation and excretion through urine over an extended period of ...
Emmanuel eStrahm, Ulf eSjöberg, Mats eGarle, Anders eRane, Lena eEkström   +4 more
doaj   +1 more source

Biosynthesis of hydroxyl-linked glucuronides of short-chain bile acids by rat liver 3-hydroxysteroid UDP-glucuronosyltransferase.

Journal of Lipid Research, 1988
Microsomal preparations from livers of Sprague-Dawley rats catalyze the glucuronidation of 3 alpha-hydroxy-5 beta-H (3 alpha, 5 beta) short-chain bile acids (C20-C23), predominantly at the hydroxyl group, while the glucuronidation of 3 beta, 5 beta short-
A Radominska, M D Green, P Zimniak, R Lester, T R Tephly   +4 more
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Glucuronidation by UGT1A1 is the dominant pathway of the metabolic disposition of belinostat in liver cancer patients.

PLoS ONE, 2013
UnlabelledBelinostat is a hydroxamate class HDAC inhibitor that has demonstrated activity in peripheral T-cell lymphoma and is undergoing clinical trials for non-hematologic malignancies.
Ling-Zhi Wang, Jacqueline Ramírez, Winnie Yeo, Mei-Yi Michelle Chan, Win-Lwin Thuya, Jie-Ying Amelia Lau, Seow-Ching Wan, Andrea Li-Ann Wong, Ying-Kiat Zee, Robert Lim, Soo-Chin Lee, Paul C Ho, How-Sung Lee, Anthony Chan, Sherry Ansher, Mark J Ratain, Boon-Cher Goh   +16 more
doaj   +1 more source

Bidirectional interactions between indomethacin and the murine intestinal microbiota

eLife, 2015
The vertebrate gut microbiota have been implicated in the metabolism of xenobiotic compounds, motivating studies of microbe-driven metabolism of clinically important drugs.
Xue Liang, Kyle Bittinger, Xuanwen Li, Darrell R Abernethy, Frederic D Bushman, Garret A FitzGerald   +5 more
doaj   +1 more source

Clinical Pharmacology of Paracetamol in Neonates: A Review

Current Therapeutic Research, 2015
Paracetamol is commonly used to control mild-to-moderate pain or to reduce opioid exposure as part of multimodal analgesia, and is the only compound recommended to treat fever in neonates.
Gian Maria Pacifici, MD, PhD, Karel Allegaert, MD, PhD   +1 more
doaj   +1 more source

UGT2B7 c.-161C>T polymorphism frequency in Croatian population

Arhiv za Higijenu Rada i Toksikologiju, 2022
Uridine diphosphate glucuronosyltransferase-2B7 (UGT2B7), enzyme responsible for the elimination of a number of xenobiotics through glucuronidation, is expressed in the gut, kidneys, intestines, and brain.
Božina Tamara, Karačić Ena, Ganoci Lana, Čuković-Čavka Silvija, Palić Jozefina, Božina Nada, Šimičević Livija   +6 more
doaj   +1 more source

The Evaluation of Genetic Profiles of UGT1A4 and UGT1A6 in the Turkish Population

Journal of Contemporary Medicine, 2021
Aim: Uridine diphosphate glucuronosyltransferases (UGTs) are a superfamily of conjugation phase II enzymes and is responsible for catalyzing the glucuronidation of many endobiotic or xenobiotic substrates.
Zuhal Uçkun Şahinoğulları
doaj   +1 more source