Results 11 to 20 of about 42,320 (201)

Molecular targeting of the UDP-glucuronosyltransferase enzymes in high-eukaryotic translation initiation factor 4E refractory/relapsed acute myeloid leukemia patients: a randomized phase II trial of vismodegib, ribavirin with or without decitabine

Haematologica, 2023
Drug resistance underpins poor outcomes in many malignancies including refractory and relapsed acute myeloid leukemia (R/R AML). Glucuronidation is a common mechanism of drug inactivation impacting many AML therapies, e.g., cytarabine, decitabine ...
Sarit Assouline, Jadwiga Gasiorek, Julie Bergeron, Caroline Lambert, Biljana Culjkovic-Kraljacic, Eftihia Cocolakis, Chadi Zakaria, David Szlachtycz, Karen Yee, Katherine L.B. Borden   +9 more
doaj   +1 more source

Effect of Efavirenz on UDP-Glucuronosyltransferase 1A1, 1A4, 1A6, and 1A9 Activities in Human Liver Microsomes

Molecules, 2012
Efavirenz is a non-nucleoside reverse transcriptase inhibitor used for the treatment of human immunodeficiency virus type 1 infections. Drug interactions of efavirenz have been reported due to in vitro inhibition of CYP2C9, CYP2C19, CYP3A4, and UDP ...
Hye Suk Lee, Hyeri Lee, Sae Rom Lim, Jeong Han Kim, Hye Young Ji   +4 more
doaj   +1 more source

Duplication, Loss, and Evolutionary Features of Specific UDP-Glucuronosyltransferase Genes in Carnivora (Mammalia, Laurasiatheria)

Animals, 2022
UDP-glucuronosyltransferases (UGTs) are one of the most important enzymes for xenobiotic metabolism or detoxification. Through duplication and loss of genes, mammals evolved the species-specific variety of UGT isoforms. Among mammals, Carnivora is one of
Mitsuki Kondo, Yoshinori Ikenaka, Shouta M. M. Nakayama, Yusuke K. Kawai, Mayumi Ishizuka   +4 more
doaj   +1 more source

Determination of major UDP-glucuronosyltransferase enzymes and their genotypes responsible for 20-HETE glucuronidation[S]

Journal of Lipid Research, 2014
The compound 20-HETE is involved in numerous physiological functions, including blood pressure and platelet aggregation. Glucuronidation of 20-HETE by UDP-glucuronosyltransferases (UGTs) is thought to be a primary pathway of 20-HETE elimination in humans.
Yazun Bashir Jarrar, Eun-Young Cha, Kyung-Ah Seo, Jong-Lyul Ghim, Hyo-Ji Kim, Dong-Hyun Kim, Su-Jun Lee, Jae-Gook Shin   +7 more
doaj   +1 more source

Maternal Nutrient Restriction Disrupts Gene Expression and Metabolites Associated with Urea Cycle, Steroid Synthesis, Glucose Homeostasis, and Glucuronidation in Fetal Calf Liver

Metabolites, 2022
This study aimed to understand the mechanisms underlying the effects of maternal undernutrition (MUN) on liver growth and metabolism in Japanese Black fetal calves (8.5 months in utero) using an approach that integrates metabolomics and transcriptomics ...
Susumu Muroya, Yi Zhang, Kounosuke Otomaru, Kazunaga Oshima, Ichiro Oshima, Mitsue Sano, Sanggun Roh, Koichi Ojima, Takafumi Gotoh   +8 more
doaj   +1 more source

Inhibitory Effects of Baicalein Derived from Japanese Traditional Herbal Medicine on SN-38 Glucuronidation

Journal of Pharmacy & Pharmaceutical Sciences, 2018
Purpose: The chemotherapeutic agent irinotecan is hydrolyzed to its active form SN-38 by human carboxyesterases, but SN-38 is converted into the inactive form SN-38G by hepatic UDP-glucuronosyltransferases (UGTs).
Takashi Satoh, Ayaka Igarashi, Misaki Tanno, Koki Yamada, Natsuko Takahashi-Suzuki, Kazuhiro Watanabe   +5 more
doaj   +1 more source

Biosynthesis of hydroxyl-linked glucuronides of short-chain bile acids by rat liver 3-hydroxysteroid UDP-glucuronosyltransferase.

Journal of Lipid Research, 1988
Microsomal preparations from livers of Sprague-Dawley rats catalyze the glucuronidation of 3 alpha-hydroxy-5 beta-H (3 alpha, 5 beta) short-chain bile acids (C20-C23), predominantly at the hydroxyl group, while the glucuronidation of 3 beta, 5 beta short-
A Radominska, M D Green, P Zimniak, R Lester, T R Tephly   +4 more
doaj   +1 more source

Implication of human UGT2B7, 2B15 and 2B17 in 19-norandrosterone metabolism

Frontiers in Endocrinology, 2013
Nandrolone (19-nortestosterone) is an anabolic androgenic steroid commonly abused for doping purposes. Nandrolone is mainly metabolized in the liver into 19-norandrosterone prior to glucuronidation and excretion through urine over an extended period of ...
Emmanuel eStrahm, Ulf eSjöberg, Mats eGarle, Anders eRane, Lena eEkström   +4 more
doaj   +1 more source

Bisphenol-A and phthalate metabolism in children with neurodevelopmental disorders.

PLoS ONE, 2023
BackgroundThe etiology of autism spectrum (ASD) and Attention Deficit/Hyperactivity (ADHD) disorders are multifactorial. Epidemiological studies have shown associations with environmental pollutants, such as plasticizers.
T Peter Stein, Margaret D Schluter, Robert A Steer, Xue Ming   +3 more
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Glucuronidation by UGT1A1 is the dominant pathway of the metabolic disposition of belinostat in liver cancer patients.

PLoS ONE, 2013
UnlabelledBelinostat is a hydroxamate class HDAC inhibitor that has demonstrated activity in peripheral T-cell lymphoma and is undergoing clinical trials for non-hematologic malignancies.
Ling-Zhi Wang, Jacqueline Ramírez, Winnie Yeo, Mei-Yi Michelle Chan, Win-Lwin Thuya, Jie-Ying Amelia Lau, Seow-Ching Wan, Andrea Li-Ann Wong, Ying-Kiat Zee, Robert Lim, Soo-Chin Lee, Paul C Ho, How-Sung Lee, Anthony Chan, Sherry Ansher, Mark J Ratain, Boon-Cher Goh   +16 more
doaj   +1 more source