Results 11 to 20 of about 49,196 (193)
Species Differences in Ezetimibe Glucuronidation
MetabolitesBackground: Peclinical and clinical studies have revealed that ezetimibe, an approved cholesterol-absorption inhibitor, is rapidly and extensively metabolized to a more potent metabolite, ezetimibe glucuronide.
Shalom Emmanuel +5 more
doaj +2 more sources
PLoS ONE, 2016 This study aimed to determine the reaction kinetics of the regioselective glucuronidation of diosmetin and chrysoeriol, two important methylated metabolites of luteolin, by human liver microsomes (HLMs) and uridine-5'-diphosphate glucuronosyltransferase (
Xuejun Zeng +10 more
doaj +2 more sources
The gut microbiome and drug-resistant epilepsy: Microbiome-antiseizure medication interactions and implications for pharmacoresistance. [PDF]
Epilepsia OpenAbstract Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy and represents a major unmet clinical need. While traditional hypotheses of pharmacoresistance have focused on alterations in drug targets, efflux transporter overexpression, and intrinsic disease severity, the gut microbiome has recently emerged as a ...
Zammar K +4 more
europepmc +2 more sources
Investigation Into the Metabolism and Elimination Behavior of RU 58841, and Its Influence on the Steroid Profile in Humans. [PDF]
Biomed ChromatogrABSTRACT RU 58841 is a nonsteroidal antiandrogen, developed for the treatment of androgen‐dependent conditions. This study aimed to characterize the human metabolism of RU 58841 for the first time and to assess its systemic exposure following topical administration.
Okutan A +4 more
europepmc +2 more sources
Effect of race and glucuronidation rates on the relationship between nicotine metabolite ratio and nicotine clearance. [PDF]
, 2021 OBJECTIVES To investigate if the nicotine metabolite ratio (NMR, the ratio of nicotine metabolites 3'-hydroxycotinine/cotinine) is a reliable phenotypic biomarker for nicotine clearance across races, and as a function of differences in the rate of ...
Jacob, Peyton +5 more
core +2 more sources
Molecules, 2012 Efavirenz is a non-nucleoside reverse transcriptase inhibitor used for the treatment of human immunodeficiency virus type 1 infections. Drug interactions of efavirenz have been reported due to in vitro inhibition of CYP2C9, CYP2C19, CYP3A4, and UDP ...
Hye Suk Lee +4 more
doaj +1 more source
Bisphenol-A and phthalate metabolism in children with neurodevelopmental disorders.
PLoS ONE, 2023 BackgroundThe etiology of autism spectrum (ASD) and Attention Deficit/Hyperactivity (ADHD) disorders are multifactorial. Epidemiological studies have shown associations with environmental pollutants, such as plasticizers.
T Peter Stein +3 more
doaj +1 more source
Journal of Lipid Research, 2014 The compound 20-HETE is involved in numerous physiological functions, including blood pressure and platelet aggregation. Glucuronidation of 20-HETE by UDP-glucuronosyltransferases (UGTs) is thought to be a primary pathway of 20-HETE elimination in humans.
Yazun Bashir Jarrar +7 more
doaj +1 more source
Range of glucuronidation efficiencies.
, 2023 BackgroundThe etiology of autism spectrum (ASD) and Attention Deficit/Hyperactivity (ADHD) disorders are multifactorial. Epidemiological studies have shown associations with environmental pollutants, such as plasticizers.
Robert A. Steer (16979607) +3 more
core +1 more source
Animals, 2022 UDP-glucuronosyltransferases (UGTs) are one of the most important enzymes for xenobiotic metabolism or detoxification. Through duplication and loss of genes, mammals evolved the species-specific variety of UGT isoforms. Among mammals, Carnivora is one of
Mitsuki Kondo +4 more
doaj +1 more source