Results 31 to 40 of about 56,416 (247)

Red wine and components flavonoids inhibit UGT2B17 in vitro [PDF]

, 2012
Background The metabolism and excretion of the anabolic steroid testosterone occurs by glucuronidation to the conjugate testosterone glucuronide which is then excreted in urine.
A Barata, A Juul, A Morgentaler, A Seemungal, AA Alomary, AL Waterhouse, Andrea Petroczi, AP Pollnitz, B Djavan, B Tariba, C Chao, C Jenkinson, C Swanson, Carl Jenkinson, CF Ferris, D Turgeon, Declan P Naughton, ET Eng, H Chiyang, HM Behre, J Jakobsson, J Key, JA Conquer, L Ekstrom, L Ekström, NS Wong, P Simonetti, R Rodrigo, S Egert, S He, S Sutcliffe, S Walorczyk, T Imamoto, T Magrone, T Sten, TL Yang   +35 more
core   +2 more sources

Glucuronidation by UGT1A1 is the dominant pathway of the metabolic disposition of belinostat in liver cancer patients.

PLoS ONE, 2013
UnlabelledBelinostat is a hydroxamate class HDAC inhibitor that has demonstrated activity in peripheral T-cell lymphoma and is undergoing clinical trials for non-hematologic malignancies.
Ling-Zhi Wang, Jacqueline Ramírez, Winnie Yeo, Mei-Yi Michelle Chan, Win-Lwin Thuya, Jie-Ying Amelia Lau, Seow-Ching Wan, Andrea Li-Ann Wong, Ying-Kiat Zee, Robert Lim, Soo-Chin Lee, Paul C Ho, How-Sung Lee, Anthony Chan, Sherry Ansher, Mark J Ratain, Boon-Cher Goh   +16 more
doaj   +1 more source

UGT2B7 c.-161C>T polymorphism frequency in Croatian population

Arhiv za Higijenu Rada i Toksikologiju, 2022
Uridine diphosphate glucuronosyltransferase-2B7 (UGT2B7), enzyme responsible for the elimination of a number of xenobiotics through glucuronidation, is expressed in the gut, kidneys, intestines, and brain.
Božina Tamara, Karačić Ena, Ganoci Lana, Čuković-Čavka Silvija, Palić Jozefina, Božina Nada, Šimičević Livija   +6 more
doaj   +1 more source

The Evaluation of Genetic Profiles of UGT1A4 and UGT1A6 in the Turkish Population

Journal of Contemporary Medicine, 2021
Aim: Uridine diphosphate glucuronosyltransferases (UGTs) are a superfamily of conjugation phase II enzymes and is responsible for catalyzing the glucuronidation of many endobiotic or xenobiotic substrates.
Zuhal Uçkun Şahinoğulları
doaj   +1 more source

Developmental changes rather than repeated administration drive paracetamol glucuronidation in neonates and infants [PDF]

, 2015
Purpose: Based on recovered metabolite ratios in urine, it has been concluded that paracetamol glucuronidation may be up-regulated upon multiple dosing.
Allegaert, K.M. (Karel), Danhof, M. (Meindert), Hoon, J.N. de, Knibbe, C.A.J. (Catherijne), Krekels, E.H.J. (Elke), Tibboel, D. (Dick), Van Ham, S. (Saskia)   +6 more
core   +3 more sources

Biosynthesis of hydroxyl-linked glucuronides of short-chain bile acids by rat liver 3-hydroxysteroid UDP-glucuronosyltransferase.

Journal of Lipid Research, 1988
Microsomal preparations from livers of Sprague-Dawley rats catalyze the glucuronidation of 3 alpha-hydroxy-5 beta-H (3 alpha, 5 beta) short-chain bile acids (C20-C23), predominantly at the hydroxyl group, while the glucuronidation of 3 beta, 5 beta short-
A Radominska, M D Green, P Zimniak, R Lester, T R Tephly   +4 more
doaj   +1 more source

Implication of human UGT2B7, 2B15 and 2B17 in 19-norandrosterone metabolism

Frontiers in Endocrinology, 2013
Nandrolone (19-nortestosterone) is an anabolic androgenic steroid commonly abused for doping purposes. Nandrolone is mainly metabolized in the liver into 19-norandrosterone prior to glucuronidation and excretion through urine over an extended period of ...
Emmanuel eStrahm, Ulf eSjöberg, Mats eGarle, Anders eRane, Lena eEkström   +4 more
doaj   +1 more source

In vitro metabolism, reaction phenotyping, enzyme kinetics, CYP inhibition and induction potential of ataluren

Pharmacology Research & Perspectives, 2020
Ataluren promotes ribosomal readthrough of premature termination codons in mRNA which result from nonsense mutations. In vitro studies were performed to characterize the metabolism and enzyme kinetics of ataluren and its interaction potential with CYP ...
Ronald Kong, Jiyuan Ma, Seongwoo Hwang, Young‐Choon Moon, Ellen M. Welch, Marla Weetall, Joseph M. Colacino, Neil Almstead, John Babiak, Elizabeth Goodwin   +9 more
doaj   +1 more source

The pharmacokinetics of anthocyanins and their metabolites in humans [PDF]

, 2014
Background and Purpose: Anthocyanins are phytochemicals with reported vasoactive bioactivity. However, given their instability at neutral pH, they are presumed to undergo significant degradation and subsequent biotransformation.
Anupongsanugool, Azzini, Bell, Cardona, Cassidy, Cassidy, Czank, Das, Del Rio, Erdman, Ferrars, Forester, Garcia-Alonso, Gonzalez-Barrio, Ichiyanagi, Kay, Kay, Kay, Kim, Kim, Kim, Manach, McGhie, Min, Mink, Miyazawa, Mullen, Nardini, Nardini, Nizamutdinova, Nurmi, Pero, Rodriguez-Mateos, Stalmach, Toromanović, Vane, Vitaglione, Wang, Williamson, Wittemer, Woodward, Woodward, Xu, Zhang, Zhang, Zhang, Zhu   +46 more
core   +1 more source

Atypical Kinetics and Albumin Effect of Glucuronidation of 5-n-Butyl-4-{4-[2-(1H-tetrazole-5- yl)-1H-pyrrol-1-yl]phenylmethyl}-2,4-dihydro-2-(2,6- dichlorophenyl)-3H-1,2,4-triazol-3-one, a Novel Nonpeptide Angiotensin Type 1 Receptor Antagonist, in Liver Microsomes and UDP-Glucuronosyl-transferase

Molecules, 2018
Ib is a new nonpeptide AT1 receptor antagonist, which plays an active role in cardiovascular protection. Ib monoglucuronide has been identified as its main metabolite.
Ying Peng, Xueyuan Zhang, Yinci Zhu, Hui Wu, Shiyin Gu, Qingqing Chang, Yi Zhou, Guangji Wang, Jianguo Sun   +8 more
doaj   +1 more source