Results 51 to 60 of about 49,196 (193)

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). I. Treatments in preclinical and early clinical development

Epilepsia, EarlyView.
Abstract Over the last 34 years, the Eilat Conference on New Antiepileptic Drugs and Devices has provided an interactive forum for stakeholders to discuss investigational and recently licensed treatments for seizures and epilepsy. The Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII) took place in Madrid, Spain, on May 3 ...
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

Impact of Species and Tissue Differences on In Vitro Glucuronidation of Diclofenac

Molecules
Background: The aim of this study is to determine the impact of species and tissue differences on the glucuronidation of diclofenac in vitro. Method: Microsomes from different species (rat, monkey, mouse, dog, and human) and rat and human tissues (liver,
Eric Asare, Shalom Emmanuel, Ting Du, Huan Xie, Dong Liang, Song Gao   +5 more
doaj   +1 more source

Apalutamide-induced severe hypothyroidism: case series and practice recommendations for thyroid management

European Thyroid Journal
The androgen receptor signaling inhibitor apalutamide is used successfully for the treatment of prostate cancer. An increased risk of hypothyroidism, mostly subclinical, has been reported in the SPARTAN and TITAN trials.
Karel David, Paul Van Crombrugge, Anne-Marie Van der Biest, Frederiek D’Hondt, Frank Claessens, Alexander Giesen, Steven Joniau, Brigitte Decallonne   +7 more
doaj   +1 more source

Advances in Anthocyanin Recovery and Purification From Natural Sources: Bioavailability, Mechanistic Action in the Human Body and Applications in Novel Food Development

Food Chemistry International, EarlyView.
This review highlights green recovery, purification, stabilisation, bioavailability, health relevance, and novel food applications of anthocyanins from natural and agro‐industrial sources. ABSTRACT Anthocyanins are water‐soluble natural pigments and multifunctional food ingredients that support clean‐label colour, antioxidant activity, and value‐added ...
Chandan Kumar Sahu, Soumitra Banerjee, Venkata Krishna Bayineni, Ravi‐Kumar Kadeppagari, Amit Arora   +4 more
wiley   +1 more source

Pharmacokinetics, Excretion, and Metabolite Profiling of Leonurine in Rats: Evidence for Extensive Phase II Conjugations

Molecules
Leonurine, a bioactive alkaloid from Leonurus japonicus, has attracted considerable pharmacological interest, yet its in vivo disposition remains insufficiently defined.
Xu Liu, Jing Hu, Yang Chen, Bin Shi, Zhanpeng Shang, Yan Liang   +5 more
doaj   +1 more source

Stabilization Strategies for Catechins and Epicatechins: Recent Advances

Food Chemistry International, EarlyView.
Oxidation, epimerization, polymerization, and hydrolysis, driven by heat, pH, and oxygen, are pathways. Nano‐/microencapsulation maintains integrity with 70%–95% efficiency; biopolymer nanoparticles, starch/polysaccharide nanocarriers improve stability and dispersion. Lipid nanocarriers enhance bioavailability but raise oxidation risk.
Nuzhat Shamim, Muhammad Usman Kahlid, Mutjardah Zarrish, Ayman Furqan, Prakram Singh Chauhan, Bipindra Pandey   +5 more
wiley   +1 more source

The Efflux Mechanism of Fraxetin-O-Glucuronides in UGT1A9-Transfected HeLa Cells: Identification of Multidrug Resistance-Associated Proteins 3 and 4 (MRP3/4) as the Important Contributors

Frontiers in Pharmacology, 2019
Fraxetin, a natural compound present in many dietary supplements and herbs, is useful in the treatment of acute bacillary dysentery and type 2 diabetes. Previously, several metabolic studies have revealed extensive first-pass metabolism causing formation
Zifei Qin, Zifei Qin, Beibei Zhang, Beibei Zhang, Jing Yang, Jing Yang, Shishi Li, Jinjin Xu, Zhihong Yao, Zhihong Yao, Xiaojian Zhang, Xiaojian Zhang, Frank J. Gonzalez, Xinsheng Yao, Xinsheng Yao   +14 more
doaj   +1 more source

Metabolism and disposition of opicapone in the rat and metabolic enzymes phenotyping

Pharmacology Research & Perspectives, 2022
Opicapone (2,5‐dichloro‐3‐(5‐(3,4‐dihydroxy‐5‐nitrophenyl)‐1,2,4‐oxadiazol‐3‐yl)‐4,6‐dimethylpyridine 1‐oxide) is a selective catechol‐O‐methyltransferase inhibitor that has been granted marketing authorization in Europe, Japan, and United States.
Ana I. Loureiro, Carlos Fernandes‐Lopes, Maria João Bonifácio, Filipa Sousa, László E. Kiss, Patricio Soares‐da‐Silva   +5 more
doaj   +1 more source

Characterization of Hepatic and Intestinal Glucuronidation of Magnolol: Application of the Relative Activity Factor Approach to Decipher the Contributions of Multiple UDP-Glucuronosyltransferase Isoforms

, 2011
Magnolol is a food additive that is often found in mints and gums. Human exposure to this compound can reach a high dose; thus, characterization of magnolol disposition in humans is very important.
Ling Yang, Finel, Moshe, Zhongze Fang, He, Guiyuan, Liang, Sicheng, Hongbo Zhang, Liu, Huixin, Dong, Peipei, 杨凌, Peipei Dong, Fang, Zhongze, Zhang, Hongbo, Moshe Finel, Zhu, Liangliang, Huixin Liu, Liangliang Zhu, Guangbo Ge, Guiyuan He, Ge, Guangbo, Yanyan Zhang, Sicheng Liang, Yang, Ling, Zhang, Yanyan   +22 more
core   +1 more source

Effects of catechins, resveratrol, silymarin components and some of their conjugates on xanthine oxidase‐catalyzed xanthine and 6‐mercaptopurine oxidation

Journal of the Science of Food and Agriculture, Volume 105, Issue 5, Page 2765-2776, 30 March 2025.
Abstract BACKGROUND Over the past two decades, the global incidence of gout has markedly increased, affecting people worldwide. Considering the side effects of xanthine oxidase (XO) inhibitor drugs (e.g. allopurinol and febuxostat) used in the treatment of hyperuricemia and gout, the potential application of phytochemicals has been widely studied.
Tímea Bencsik, Orsolya Balázs, Róbert G Vida, Balázs Z Zsidó, Csaba Hetényi, Kateřina Valentová, Miklós Poór   +6 more
wiley   +1 more source