Results 71 to 80 of about 49,196 (193)
Catechins and Their Effect on the Gut Microbiome in Health and Cancer
Phytotherapy Research, EarlyView.ABSTRACT Catechins are a group of flavonoids found primarily in green tea, fruits, and berries; they play a significant role in the modulation of the gut microbiota, thereby having an impact on gut health and cancer prevention. Owing to their low bioavailability, catechins are transformed by the gut microbiota into various bioactive metabolites such as
Prakash Monika +5 more
wiley +1 more source
Molecules, 2019 GL-V9 is a prominent derivative of wogonin with a wide therapeutic spectrum and potent anti-tumor activity. The metabolism characteristics of GL-V9 remain unclear.
Han Xing +12 more
doaj +1 more source
, 2010 Diethylstilbestrol (DES), a synthetic estrogen, was once prescribed to pregnant women to reduce the risk of pregnancy complications and losses, and now in treatment for breast and prostate cancers and locally for estrogen deficiencies. It has been proved
葛广波, 杨凌, 朱亮亮, 刘慧鑫
core
Ontogeny of Hepatic Glucuronidation; Methods and Results
, 2012 The onset and maturation, or so-called ontogeny, of hepatic glucuronidation is important for the clearance of a number of drugs in children. The current review discusses methods for studying the ontogeny of liver enzyme systems and specifically focuses ...
Krekels, EHJ +3 more
core +1 more source
Phytotherapy Research, EarlyView.ABSTRACT Asthma affects 260–300 million people worldwide. About 20%–35% of patients use medicinal plants with their asthma medication, often without telling their clinicians. Disclosure rates are low; up to 42% of asthma outpatients use herbal products, with no records in their charts.
Emine Kocyigit +5 more
wiley +1 more source
Characterization of CYPs and UGTs Involved in Human Liver Microsomal Metabolism of Osthenol
Pharmaceutics, 2018 Osthenol is a prenylated coumarin isolated from the root of Angelica koreana and Angelica dahurica, and is an O-demethylated metabolite of osthole in vivo. Its various pharmacological effects have been reported previously.
Pil Joung Cho +7 more
doaj +1 more source
Characterization of UGT Isoforms Involved in Naringenin Glucuronidation in Human Liver Microsomes
, 2010 Characterization of UGT Isoforms Involved in Naringenin Glucuronidation in Human Liver ...
胡莹, 杨凌, 刘慧鑫
core
Glucuronidation of β-lap in HT29 cell S9 fractions.
, 2015 HT29 cells S9 were incubated with β-lap according to the details in methods. (A) A typical Michaelis-Menten kinetics of β-lap glucuronidation in HT29 cells S9 fractions; (B) UGT1A siRNA treated HT29 cells S9 fractions significantly decreases β-lap ...
Huiying Liu (148261) +5 more
core +1 more source
Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges
British Journal of Pharmacology, EarlyView.This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu +6 more
wiley +1 more source
In Vitro Glucuronidation of Ochratoxin A by Rat Liver Microsomes
Toxins, 2013 Ochratoxin A (OTA), one of the most toxic mycotoxins, can contaminate a wide range of food and feedstuff. To date, the data on its conjugates via glucuronidation request clarification and consolidation.
Zheng Han +6 more
doaj +1 more source