Results 81 to 90 of about 56,416 (247)
Metabolism of the dihydropyridine calcium channel blockers mebudipine and dibudipine by isolated rat hepatocytes [PDF]
The prototype 1,4-dihydropyridine (1,4-DHP) nifedipine, indicated for the management of hypertension and angina pectoris, has drawbacks of rapid onset of vasodilating action and a short half-life.
Baarnhielm +15 more
core +1 more source
Bacterial reduction of N-oxides of tobacco- specific nitrosamines (TSNA) [PDF]
, 1996 1 Contrary to established metabolic pattern, a recent investigation of NNK metabolism produced in rat urine higher levels of 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone (NNK) and 4-(methylnitrosamino)-1-(3-pyri dyl)-1-butanol (NNAL) than their N ...
Calmels S. +4 more
core +1 more source
Gas Chromatography of Glucuronides.
Chemical and Pharmaceutical Bulletin, 1967 The applicability of gas chromatography to the analysis of various types of glucuronides including ether-, ester-, N-and S-glucuronides was studied by converting them to acetyl, methyl and trimethylsilyl derivatives.
T, Imanari, Z, Tamura
openaire +3 more sources
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai +6 more
wiley +1 more source
Characterization of CYPs and UGTs Involved in Human Liver Microsomal Metabolism of Osthenol
Pharmaceutics, 2018 Osthenol is a prenylated coumarin isolated from the root of Angelica koreana and Angelica dahurica, and is an O-demethylated metabolite of osthole in vivo. Its various pharmacological effects have been reported previously.
Pil Joung Cho +7 more
doaj +1 more source
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 510-522, March 2025.Abstract Topiramate (TPM) is a broad‐spectrum antiepileptic drug (AED) commonly prescribed for approved and off‐label uses. Routine monitoring is suggested for clinical usage of TPM in special population due to its broad side effect profile. Therefore, it is crucial to further explore its pharmacokinetic characteristics.
Shuqing Chen +6 more
wiley +1 more source
In Vitro Glucuronidation of Ochratoxin A by Rat Liver Microsomes
Toxins, 2013 Ochratoxin A (OTA), one of the most toxic mycotoxins, can contaminate a wide range of food and feedstuff. To date, the data on its conjugates via glucuronidation request clarification and consolidation.
Zheng Han +6 more
doaj +1 more source
The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids [PDF]
, 2016 At a population level there is growing evidence for the beneficial effects of dietary flavonoids on health. However there is extensive heterogeneity in the response to increased intake, which is likely mediated via wide inter-individual variability in ...
Cassidy, Aedin, Minihane, Anne-Marie
core +1 more source
Phytochemicals in MASLD: A Focused Review of Gut Microbiome‐Linked Mechanisms
Phytotherapy Research, EarlyView.ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as a major global health burden, yet effective pharmacological options remain limited. Recent advances highlight the gut microbiome as a key modulator of liver metabolism, inflammation, and fibrosis, making it a promising therapeutic target.
Jeong In Seo, Su Min Kim, Hye Hyun Yoo
wiley +1 more source
Regulation of Hepatic UGT2B15 by Methylation in Adults of Asian Descent
Pharmaceutics, 2018 The hepatic uridine 5′-diphosphate-glucuronosyl transferases (UGTs) are critical for detoxifying endo- and xenobiotics. Since UGTs are also dynamically responsive to endogenous and exogenous stimuli, we examined whether epigenetic DNA methylation can ...
Steffen G. Oeser +2 more
doaj +1 more source