Results 81 to 90 of about 49,196 (193)

Characterization of UGT Isoforms Involved in Liquiritigenin Glucuronidation in Human Liver Microsomes

, 2010
Characterization of UGT Isoforms Involved in Liquiritigenin Glucuronidation in Human Liver ...
胡莹, 杨凌, 刘慧鑫
core  

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, EarlyView.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

Regulation of Hepatic UGT2B15 by Methylation in Adults of Asian Descent

Pharmaceutics, 2018
The hepatic uridine 5′-diphosphate-glucuronosyl transferases (UGTs) are critical for detoxifying endo- and xenobiotics. Since UGTs are also dynamically responsive to endogenous and exogenous stimuli, we examined whether epigenetic DNA methylation can ...
Steffen G. Oeser, Jon-Paul Bingham, Abby C. Collier   +2 more
doaj   +1 more source

Characterization of Human UDP-Glucuronosyltransferase Isoforms Responsible for the in vitro Glucuronidation of Esculetin

, 2009
Esculetin (6,7-dihydroxycoumarin), is one of coumarin analogs isolated from various plant including Cichorium intybus, Artemisia scoparia and Fraxinus japonica Blume, has been found to exhibit broaden biological effects, such as analgesic, anti ...
梁思成, 张延延, 葛广波, 杨凌, 刘慧鑫   +4 more
core  

Glucuronidation of thyroid hormone by human bilirubin and phenol UDP-glucuronyltransferase isoenzymes [PDF]

, 1993
The glucuronidation of thyroid hormone by UDP-glucuronyltransferases (UGTs) stably transfected in Chinese hamster V79 lung fibroblasts was investigated.
Ellen Kaptein, Thomas Ebner, Visser, Theo J., Brian Burchell, Visser, Theo, Anthonie L. Gijzel, Theo J. Visser, Burchell, Brian, de Herder, Wouter W., Wouter W. de Herder, Kaptein, Ellen, Gijzel, Anthonie L., Ebner, Thomas   +12 more
core   +1 more source

Androgen Glucuronidation in Mice: When, Where, and How

, 2022
Glucuronidation, catalyzed by UDP-glucuronosyltransferase UGT2B enzymes, is a major inactivating and elimination pathway for androgen hormones in humans.
Laurent Grosse, Olivier Barbier, Alain Bélanger, Sophie Pâquet, Sarah Chouinard, Mélanie Verreault, Jocelyn Trottier   +6 more
core   +1 more source

Pharmacokinetics of Buccally Administered Cannabidiol and Oral Carprofen During Single‐ and Repeated‐Dose Administration in Dogs

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Cannabidiol (CBD) is increasingly used as an adjunct treatment for chronic pain in dogs, but information on repeated‐dose pharmacokinetics and potential interactions with commonly used analgesics remains limited. This study evaluated the pharmacokinetics of buccally administered CBD, its major metabolites, and orally administered carprofen in ...
Tilen Vake, Katerina Tomsič, Žiga Žgank, Mihaela Klasić, Janja Babič, Zlatka Bajc, Jožica Dolenc, Gabrijela Tavčar Kalcher, Odon Planinšek, Tomaž Snoj   +9 more
wiley   +1 more source

Characterization of Human UDP-Glucuronosyltransferases responsible for the in vitro Glucuronidation of Armillarisin A

, 2010
Armillarisin A, a new coumarin derivative isolated from the fungus Armillariella tabescens (Scop. ex Fr.) Singer, has been used for treatment of acute cholecystitis, infection of biliary system and pancreatitis in China for several years, but its ...
梁思成, 房中则, 葛广波, 孙冬雪, 杨凌, 朱亮亮   +5 more
core  

(Poly)phenols: Mechanisms of action and efficacy of contemporary supplements for exercise recovery and performance

Experimental Physiology, EarlyView.
Abstract (Poly)phenols are a diverse group of bioactive chemical compounds present in a wide range of plant‐ and animal‐based foods. Several thousands of (poly)phenols exist; many have potent biological effects, most notably antioxidant, anti‐inflammatory and vasodilatory.
Glyn Howatson, Tom Clifford
wiley   +1 more source

Comparative Pharmacokinetics of Six Bioactive Constituents From Danggui Jixueteng Decoction in Normal and Myelosuppressive Rats

Analytical Science Advances, Volume 7, Issue 2, December 2026.
ABSTRACT This study compared the pharmacokinetics of six constituents from Danggui Jixueteng Decoction in normal versus carboplatin‐induced myelosuppressive rats. A rapid, sensitive ultra‐high performance liquid chromatography‐tandem mass spectrometry method was developed and validated for simultaneous quantification of six diverse constituents (8‐O ...
Mingxin Guo, Yingjie Liu, Zhiqiang Hu, Xiayu Liu   +3 more
wiley   +1 more source