Results 81 to 90 of about 42,320 (201)

Isoursodeoxycholic acid: metabolism and therapeutic effects in primary biliary cirrhosis1

Journal of Lipid Research, 2001
Significant amounts of ursodeoxycholic acid (UDCA) used for the treatment of patients with primary biliary cirrhosis (PBC) become epimerized at C-3 to isoUDCA. We investigated the metabolism of isoUDCA and a possible pharmacologic effect in five patients
Hanns-Ulrich Marschall, Ulrika Broomé, Curt Einarsson, Gunvor Alvelius, Hans Günther Thomas, Siegfried Matern   +5 more
doaj   +1 more source

Glucuronide metabolism in plants. 3. Triterpene glucuronides [PDF]

Biochemical Journal, 1956
C A, MARSH, G A, LEVVY
openaire   +2 more sources

Research on the Mechanism of Natural Products Acting on Chronic Obstructive Pulmonary Disease

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
This figure illustrates that approximately 80 natural compounds exert therapeutic effects against chronic obstructive pulmonary disease by targeting pathological mechanisms such as airway inflammation, oxidative stress, airway remodeling, mucus hypersecretion, emphysema, protease–antiprotease imbalance, apoptosis, and autophagy.
Shuna Wei, Xiaoju Liu
wiley   +1 more source

Characterization of Phase I and Glucuronide Phase II Metabolites of 17 Mycotoxins Using Liquid Chromatography—High-Resolution Mass Spectrometry

Toxins, 2019
Routine mycotoxin biomonitoring methods do not include many mycotoxin phase I and phase II metabolites, which may significantly underestimate mycotoxin exposure especially for heavily metabolized mycotoxins. Additional research efforts are also needed to
Irina Slobodchikova, Reajean Sivakumar, Md Samiur Rahman, Dajana Vuckovic   +3 more
doaj   +1 more source

Unraveling the Bioactive Compounds and Multi‐Target Mechanisms of the Fructus Aurantii Immaturus‐Bambusae Caulis in Taeniam Herb Pair Against Chronic Gastritis: Integrating Identification of Absorbed Constituents, Targeted Network Pharmacology, and Computational Validation

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
This work systematically explored the anti‐chronic gastritis mechanism of the FAI‐BCT herb pair. UPLC‐Q‐TOF‐MS/MS was applied to identify absorbed prototypes and metabolites of FAI‐BCT in rat plasma. Combining database mining, network pharmacology, molecular docking, and molecular dynamics simulation, we screened the key bioactive components and core ...
Yinghua Ma, Weiwei Xie, Jing Song, Yabin Qin, Yile Zhao   +4 more
wiley   +1 more source

Population Pharmacokinetics and Pharmacodynamics of Paracetamol in Malaysian Patients With Plasmodium knowlesi Malaria

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 7, July 2026.
ABSTRACT Paracetamol may improve renal function in patients with severe Plasmodium knowlesi malaria, particularly in those with acute kidney injury and hemolysis, via inhibition of cell‐free hemoglobin mediated oxidative kidney damage. We developed a population pharmacokinetic/pharmacodynamic (PK/PD) model to assess effects of paracetamol on creatinine,
Thanaporn Wattanakul, Daniel J. Cooper, Katherine Plewes, Matthew J. Grigg, Giri S. Rajahram, Timothy William, Arjen M. Dondorp, Michael D. Edstein, Geoffrey W. Birrell, Nicholas M. Anstey, Richard M. Hoglund, Bridget E. Barber, Joel Tarning   +12 more
wiley   +1 more source

Butorphanol Pharmacokinetics Across Species: Meta‐Analysis Integrating Allometric Scaling and Minimal Physiologically Based Pharmacokinetic Modeling

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 7, July 2026.
mPBPK Allometric Meta‐Analysis (MAMA) of Butorphanol Across 13 Species. ABSTRACT Butorphanol, an opioid agonist–antagonist used in human and veterinary medicine, lacks systematic interspecies comparisons. Butorphanol pharmacokinetics (PK) was assessed across species using a minimal physiologically based PK (mPBPK) model and allometric scaling, termed ...
Ahmed M. Saeed, William J. Jusko
wiley   +1 more source

Drug Interactions of Vebreltinib, a Novel Type I c‐Met Inhibitor, Coadministration With Rifampin or Itraconazole in Healthy Participants

Clinical and Translational Science, Volume 19, Issue 7, July 2026.
Pharmacokinetic and drug–drug interaction evaluation of vebreltinib in healthy participants, showing decreased exposure with rifampin and increased exposure with itraconazole. ABSTRACT Vebreltinib is a novel, highly selective type I c‐Met inhibitor developed for treating non–small cell lung cancer (NSCLC) and glioma.
Jingcheng Chen, Jingxuan Wu, Yuqin Song, Jiangshuo Li, Linna li, Lijun Li, Yanhong Kong, Xiaofang Wu, Hang Yin, Mengyu Hou, Bingyan Wang, Qiannan Gao, Ran Li, Le Wu, Weizhe Xue, Ruihua Dong   +15 more
wiley   +1 more source

The pharmacology of gepants in migraine: A scoping review on mechanisms, clinical applications, and combination strategies

Headache: The Journal of Head and Face Pain, Volume 66, Issue 7, Page 1628-1643, July/August 2026.
Abstract Background Calcitonin gene‐related peptide (CGRP) is a key mediator in migraine pathophysiology, and the development of gepants, novel CGRP receptor antagonists, has expanded therapeutic options for both acute and preventive treatment. This scoping review aims to synthesize current evidence on the pharmacology, clinical applications, safety ...
Luigi Francesco Iannone, Marcello Silvestro, Antonio Munafò, Marina Romozzi, Pierangelo Geppetti, Antonio Russo   +5 more
wiley   +1 more source

Utilization of carbon catabolite repression for efficiently biotransformation of anthraquinone O-glucuronides by Streptomyces coeruleorubidus DM

Frontiers in Microbiology
Carbon catabolite repression (CCR) is a highly conserved mechanism that regulates carbon source utilization in Streptomyces. CCR has a negative impact on secondary metabolite fermentation, both in industrial and research settings.
Chen Tao, Quyi Wang, Junyang Ji, Ziyue Zhou, Bingjie Yue, Ran Zhang, Shu Jiang, Shu Jiang, Tianjie Yuan   +8 more
doaj   +1 more source