Results 101 to 110 of about 42,320 (201)

UGTformer: a pretrained graph transformer model for predicting UDP-glucuronosyltransferase-mediated drug metabolism. [PDF]

J Cheminform
Zhan M, Li X, Xiong L, Song W, Fang J, Liu G, Tang Y, Li W.   +7 more
europepmc   +1 more source

Exploring the pharmacokinetic mechanisms that affect bictegravir exposure during pregnancy. [PDF]

J Antimicrob Chemother
van der Wekken-Pas L, Hidalgo-Tenorio C, Rockstroh JK, van Bremen K, Richel O, Molto J, Lambert JS, de Kanter C, Konopnicki D, Burger D, Colbers A.   +10 more
europepmc   +1 more source

Characterization of the Formation of the Acyl Glucuronide Metabolite of 7-Carboxy-Cannabidiol in Human Liver, Kidney, and Intestinal Microsomes and <i>in Vivo</i> in Mice. [PDF]

ACS Med Chem Lett
Simon KT, Hailemariam SE, Friedman E, Wen YW, Freaney M, Barker-Haliski M, Isoherranen N.   +6 more
europepmc   +1 more source

Biotransformation and kinetics of selected benzimidazole synthetic opioids in human hepatocytes. [PDF]

Front Pharmacol
Jadhav GR, Fasinu PS.
europepmc   +1 more source

Modulatory effects of valproic acid and UGT polymorphisms on norclozapine plasma levels in clozapine-treated patients with schizophrenia. [PDF]

Sci Rep
Sangüesa E, Cirujeda C, Bernal A, Ribate MP, García CB.   +4 more
europepmc   +1 more source

Comments to the Article Wu Y, Völler S, Goulooze SC, et al. A Novel Maturation Equation for Hepatic Clearance Across Preterm, Term Neonates, Children, and Adults: Application to Paracetamol and Its Metabolite. J Clin Pharmacol. 2025;65(12):1829-1843. doi: 10.1002/jcph.70080. PMID: 40910464; PMCID: PMC12649303. [PDF]

J Clin Pharmacol
Pasanen M, Juvonen RO.
europepmc   +1 more source

UGT2B15 Acts as a Critical Detoxification Barrier Against Chemi-Cal-Induced Hepatotoxicity and Carcinogenesis via the Androgen Receptor Axis. [PDF]

Cells
Zhao Y, Wang Y, Li Y, Liu S, Jia Z, Wang Y, Zhang R, Liu Z, Lu L.   +8 more
europepmc   +1 more source

(Salen)Metal-Catalyzed β-Glucuronidation of Alcohols, Phenols, and Anilines. [PDF]

J Am Chem Soc
Beyer PD, Jacobsen EN.
europepmc   +1 more source

Discovery of a Colon-Targeted Prodrug As an <i>Escherichia coli</i> Biofilm Inhibitor for Treating Inflammatory Bowel Disease. [PDF]

ACS Med Chem Lett
Shimizu T, Tago K, Yokoyama M, Nakamura K, Tokieda-Tanoue S, Kita A, Miyazaki S.   +6 more
europepmc   +1 more source

A Multi-Omics Study Reveals the Active Components and Therapeutic Mechanism of Erhuang Quzhi Formula for Non-Alcoholic Fatty Liver Disease. [PDF]

Nutrients
Ma T, Li M, Liu Y, Chen Y, Guan Z, Liu T, Qin D, Xu J.   +7 more
europepmc   +1 more source