Results 111 to 120 of about 49,196 (193)

Stable Knock-down of Efflux Transporters Leads to Reduced Glucuronidation in UGT1A1-Overexpressing HeLa Cells: The Evidence for Glucuronidation-Transport Interplay

, 2015
Efflux of glucuronide is facilitated by the membrane transporters including BCRP and MRPs. In this study, we aimed to determine the effects of transporter expression on glucuronide efflux and cellular glucuronidation.
Dong Dong (23216), Yifei Wang (95207), Zhiguo Ma (842755), Huailing Wang (1626064), Baojian Wu (655083), Xingwang Zhang (587405)   +5 more
core   +1 more source

A Review of Nonsteroidal Anti‐Inflammatory Drugs for Food‐Producing Animals With a Focus on Potential Applications for Farmed Finfish

Journal of Fish Diseases, Volume 49, Issue 10, October 2026.
ABSTRACT In finfish aquaculture, there are several inflammatory diseases impacting productivity and animal welfare, however there are limited options available to veterinarians to treat inflammation and pain in fish. Nonsteroidal anti‐inflammatory drugs (NSAIDs) are widely used in terrestrial animals raised for human consumption to treat a range of ...
Chloe J. English, Christine Huynh, William Roy, James W. Wynne, Hamish Rodger   +4 more
wiley   +1 more source

N-glucuronidation of nicotine and cotinine by human liver microsomes and heterologously expressed UDPglucuronosyltransferases. Drug Metab [PDF]

, 2003
This article is available online at http://dmd.aspetjournals.org ABSTRACT: Nicotine is considered the major addictive agent in tobacco. Tobacco users extensively metabolize nicotine to cotinine. Both nicotine and cotinine undergo N-glucuronidation. Human
Sharon E Murphy, Gwendolyn E Kuehl
core  

蟾蜍内酯类3-表异构体的立体特异性葡萄糖醛酸化研究

, 2010
Bufadienolides, a class of natural products with a unique steroidal skeleton were separated and identified from traditional Chinese medicine Chansu, has been reported with Na+-K+-ATPase inhibitory effects and outstanding antitumor activities.
梁思成, 葛广波, 宁静, 杨凌, 马骁驰   +4 more
core  

Glucuronidation of apomorphine

, 2000
Apomorphine, a dopaminergic receptor agonist, is largely used in the therapy of Parkinson's disease. In this study, we characterized the glucuronidation of apomorphine and other catechols in rat liver and brain microsomes, using UDP-[U-14C]glucuronic ...
Leclerc, S., Magdalou, J., Netter, Patrick, Minn, A., El-Bachá, Ramon dos Santos   +4 more
core  

Utilization of carbon catabolite repression for efficiently biotransformation of anthraquinone O-glucuronides by Streptomyces coeruleorubidus DM

Frontiers in Microbiology
Carbon catabolite repression (CCR) is a highly conserved mechanism that regulates carbon source utilization in Streptomyces. CCR has a negative impact on secondary metabolite fermentation, both in industrial and research settings.
Chen Tao, Quyi Wang, Junyang Ji, Ziyue Zhou, Bingjie Yue, Ran Zhang, Shu Jiang, Shu Jiang, Tianjie Yuan   +8 more
doaj   +1 more source

Identification and characterization of human UDP-glucuronosyltransferases responsible for the in vitro glucuronidation of ursolic acid

, 2016
This study aims to characterize the glucuronidation kinetics of ursolic acid (UA) in human liver microsomes (HLMs) and intestinal microsomes (HIMs) and identify the main UDP-glucuronosyltransferases (UGTs) involved. In our present study, only one type of
Huang, Shibo, Liu, Mingyi, Gao, Rui, Zhang, Hong, Xia, Chunhua, Chen, Yu, Xiong, Yuqing   +6 more
core   +1 more source

Inhibition of glucuronidation by an acyl-CoA-mediated indirect mechanism

, 1996
The mechanism of the inhibition of glucuronidation by long-chain fatty acyl-CoAs was studied in rat liver microsomal membranes and in isolated hepatocytes.
Fulceri, R., Benedetti, A., Giunti, R., Mandl, J., Bánhegyi, G., Kardon, T., Csala, M., Gamberucci, A.   +7 more
core   +1 more source

ASSESSMENT OF CATECHOL INDUCTION AND GLUCURONIDATION IN RAT LIVER MICROSOMES

, 2020
: Catechols are substances with a 1,2-dihydroxybenzene group from natural or synthetic origin. The aim of this study was to determine whether catechols (4-methylcatechol, 4-nitrocatechol, 2,3-dihydroxynaphthalene) and the antiparkinsonian drugs ...
Brian Burchell, Eivor Elovaara, Sylvie Fournel-Gigleux, Laurence Antonio, Jouni Mikkola, Jyrki Taskinen, Jacques Magdalou, Leena Luukkanen   +7 more
core  

Characterization of in vitro glucuronidation clearance of a range of drugs in human kidney microsomes: Comparison with liver and intestinal glucuronidation and impact of albumin

, 2012
Previous studies have shown the importance of the addition of albumin for characterization of hepatic glucuronidation in vitro; however, no reports exist on the effects of albumin on renal or intestinal microsomal glucuronidation assays.
Houston, J. Brian, Galetin, Aleksandra, Gill, Katherine L.   +2 more
core   +1 more source