Results 91 to 100 of about 49,196 (193)

Insights into the Metabolism, Disposition, and Quantitative Profile of mGlu5 NAM AE90015 with Metabolite Identification and a Novel Integration Method

Molecules
AE90015 is a highly specific and effective negative allosteric modulator (NAM) for the human mGlu5 receptor, showing significant promise for treating Parkinson’s disease.
Zhiyang Zack Zou, Ming-Jie Han, Yu Chang, Guiying Li   +3 more
doaj   +1 more source

CHARACTERIZATION OF CATECHOL GLUCURONIDATION IN RAT LIVER

, 2020
This paper is available online at http://dmd.aspetjournals.org ABSTRACT: Catechols are a class of substances from natural or synthetic origin that contain a 1,2-dihydroxybenzene group. We have characterized the glucuronidation by rat liver microsomes and

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Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, Volume 46, Issue 6, Page 1477-1498, November 2026.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Glucuronidation of tobacco-specific nitrosamines by UGT2B10 [PDF]

, 2008
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) is an important tobacco-specific nitrosamine (TSNA) in the etiology of tobacco-related cancers, and N-glucuronidation is an important mechanism of NNAL detoxification. In the present study, an analysis
Spratt, Thomas E, Lazarus, Philip, Sun, Dongxiao, Dellinger, Ryan W, Chen, Gang   +4 more
core   +1 more source

Olanzapine for the Prevention and Treatment of ICU Delirium: Protocol for a Systematic Review With Meta‐Analysis

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 10, November 2026.
ABSTRACT Background Intensive care unit (ICU) delirium is a multifactorial acute brain dysfunction associated with prolonged hospitalization, increased morbidity and mortality, and higher healthcare costs. Despite these substantial negative impacts of delirium, the optimal prevention and treatment strategies are unclear.
Benedikte Liebetrau, Andreas Ruhvald Madsen, Sören Möller, Markus Harboe Olsen, Sebastian Wiberg, Simon Mølstrøm   +5 more
wiley   +1 more source

UDP-glucuronosyltransferase 1A6 is the major isozyme responsible for protocatechuic aldehyde glucuronidation in human liver microsomes

, 2008
Glucuronidation is an important pathway in the metabolism of protocatechuic aldehyde (3,4-dihydroxybenzaldehyde, PAL). However, the metabolites and primary UDP-glucuronosyltransferase (UGT) isozymes responsible for PAL glucuronidation remain to be ...
Liu, Hong-Tao, Zhang, Jiang-Wei, Liu, Hui-Xin, Li, Wei, Liu, Yong, Yang, Ling   +5 more
core   +1 more source

Multi-Omics in Predicting Lamotrigine Neurotoxicity: Current Opportunities (Review)

Безопасность и риск фармакотерапии
INTRODUCTION. Lamotrigine (LTG) is among the most commonly prescribed second-generation antiepileptic drugs due to its low teratogenic risk. However, lamotrigine has pronounced neurotoxic, hepatotoxic, dermatotoxic potential (for genetic and metabolic ...
N. A. Shnayder, V. V. Bader, R. F. Nasyrova, M. Ya. Kissin   +3 more
doaj   +1 more source

Lipid-based nanosystem of edaravone: development, optimization, characterization and in vitro/in vivo evaluation

Drug Delivery, 2017
Edaravone (EDR) is a well-recognized lipophilic free radical scavenger for diseases including neurodegenerative disease, cardiovascular disease, and cancer. However, its oral use is restricted due to poor oral bioavailability (BA).
Ankit Parikh, Krishna Kathawala, Chun Chuan Tan, Sanjay Garg, Xin-Fu Zhou   +4 more
doaj   +1 more source

Divergent Expression and Metabolic Functions of Human Glucuronosyltransferases through Alternative Splicing

Cell Reports, 2016
Maintenance of cellular homeostasis and xenobiotic detoxification is mediated by 19 human UDP-glucuronosyltransferase enzymes (UGTs) encoded by ten genes that comprise the glucuronidation pathway.
Michèle Rouleau, Alan Tourancheau, Camille Girard-Bock, Lyne Villeneuve, Jonathan Vaucher, Anne-Marie Duperré, Yannick Audet-Delage, Isabelle Gilbert, Ion Popa, Arnaud Droit, Chantal Guillemette   +10 more
doaj   +1 more source

Size does matter : drug glucuronidation in children [PDF]

, 2012
The maturation of UGT2B7-mediated drug glucuronidation was studied in preterm and term neonates up to infants of three years of age using a population approach.
Krekels, E.H.J.
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