Results 121 to 130 of about 49,196 (193)

Inhibitory actions of dietary and pharmaceutical components on steroid glucuronidation [PDF]

Anabolic steroid abuse remains the most potent and frequent form of doping in elite sports, originally utilising synthetic potent anabolic steroids. However, advances in highly sensitive mass spectrometry-based urine drug screens for synthetic anabolic ...
Jenkinson, Carl
core  

UGT1A and UGT2B Genetic Variation Alters Nicotine and Nitrosamine Glucuronidation in European and African American Smokers

, 2015
BACKGROUND: Identifying sources of variation in the nicotine and nitrosamine metabolic inactivation pathways is important to understanding the relationship between smoking and cancer risk.
Das, Soma, Chen, Peixian, Wassenaar, Catherine A, Ratain, Mark J, Conti, David V, Tyndale, Rachel F, Benowitz, Neal L, Cook, Edwin H   +7 more
core   +1 more source

Species difference in glucuronidation formation kinetics with a selective mTOR inhibitor DMD #54809 2 Running Title: Glucuronidation of an mTOR inhibitor

, 2020
Non-standard abbreviations: CL, clearance; CLint, intrinsic clearance; IV, intravenous; LC-MS/MS, liquid chromatography tandem mass spectrometry; mTOR, mammalian target of rapamycin; PK, pharmacokinetics; UGT, UDP glucuronosyltransferase; NADPH, reduced ...
Yohannes Teffera, Paul Krolikowski, Jingzhou Liu, Zhiyang Zhao, A C, L M B, Loren M Berry, Y T, Adria Colletti, Z Z, Discovery Research, J L, P K   +12 more
core  

Dietary green and white teas suppress UDP-glucuronosyltransferase UGT2B17 mediated testosterone glucuronidation

, 2012
The anabolic steroid testosterone can be used by athletes to enhance athletic performance and muscle growth. UDP-glucuronosyltransferase (UGT2B17) is the key enzyme involved in the glucuronidation of testosterone to testosterone glucuronide, which also ...
Jenkinson, Carl, Petroczi, Andrea, Naughton, Declan P., Barker, James   +3 more
core   +1 more source

In Vitro Glucuronidation of Wushanicaritin by Liver Microsomes, Intestine Microsomes and Expressed Human UDP-Glucuronosyltransferase Enzymes

, 2017
Wushanicaritin, a natural polyphenol compound, exerts many biological activities. This study aimed to characterize wushanicaritin glucuronidation by pooled human liver microsomes (HLM), human intestine microsomes and individual uridine diphosphate ...
Frank Gonzalez, Xiaodan Hong, Zifei Qin, Baojian Wu, Hao Gao, Xinsheng Yao, Yi Dai, Yuanru Zheng, Zhihong Yao   +8 more
core   +1 more source

CHARACTERIZATION OF AFLOQUALONE N-GLUCURONIDATION: SPECIES DIFFERENCES AND IDENTIFICATION OF HUMAN UDP-GLUCURONOSYLTRANSFERASE ISOFORM(S)

, 2020
: Afloqualone (AFQ) is one of the centrally acting muscle relaxants. AFQ N-glucuronide is the most abundant metabolite in human urine when administered orally, whereas it was not detected in the urine when administered to rats, dogs, and monkeys. Species
Toshiyuki Kume, Hidefumi Kaji
core  

La glucuronidation des acides biliaires est une cible pharmacologique prometteuse pour le traitement des pathologies cholestatiques

, 2018
Introduction : La glucuronidation a pour effet de rediriger l’élimination des acides biliaires (AB) vers l’urine. En état cholestatique, caractérisé par une interruption du flux biliaire, ce métabolisme pourrait représenter une cible pharmacologique car ...
Perreault, Martin
core  

Profiling and Identification of Novel Tiletamine Metabolites in Human Urine and Hair by Liquid Chromatography Coupled With Quadrupole-Orbitrap Mass Spectrometry. [PDF]

Rapid Commun Mass Spectrom
Qin S, Bi G, Wang Y, Liu B, Cui Z, Zhao X, Wu X, Jing J, Lu J.   +8 more
europepmc   +1 more source

The Dual Role of Human UDP-Glucuronosyltransferase-Mediated Metabolism in Tumor Drug Resistance: Mechanisms and Prospects. [PDF]

Int J Mol Sci
Wang Z, Zhong J, Ren C, Shi H, Fang X, Xiao X, Liu X, Cao D, Zeng X.   +8 more
europepmc   +1 more source

Publisher Correction: A robust and validated method for the determination of 21 urinary metabolites of 15 plasticizers, including phthalates, DEHTP, and DINCH, by online SPE and liquid chromatography‑tandem mass spectrometry. [PDF]

Anal Bioanal Chem
Mercadante R, Cafagna S, Rizzo M, Roggia E, Fustinoni S.   +4 more
europepmc   +1 more source