Results 121 to 130 of about 56,416 (247)
The Journal of Clinical Pharmacology, Volume 66, Issue 5, May 2026.Abstract A recent article in this journal by Wu et al presented a comprehensive model for the maturation of paracetamol clearance from birth to adulthood using pooled plasma and urinary data of the parent drug and its metabolites from 298 subjects. The modeling showed that the oxidative bioactivation to hepatotoxic metabolite N‐acetyl‐p‐benzoquinone ...
Markku Pasanen, Risto O. Juvonen
wiley +1 more source
Isocitrate Dehydrogenase Mutations in Cancer: From Bench to Bedside Applications
MedComm, Volume 7, Issue 5, May 2026.Mutant isocitrate dehydrogenase affects multiple cancer types. Alterations in IDH1 and IDH2 result in abnormal enzyme activity, leading to the overproduction of D‐2‐hydroxyglutarate (D‐2HG). This metabolite disrupts cellular metabolism and epigenetic regulation, driving cancer initiation, progression, and metastasis.
Yuhan Fang +6 more
wiley +1 more source
Use of Physiologically Based Biokinetic (PBBK) Modeling to Study Estragole Bioactivation and Detoxification in Humans as Compared with Male Rats [PDF]
, 2017 The extent of bioactivation of the herbal constituent estragole to its ultimate carcinogenic metabolite 1′-sulfooxyestragole depends on the relative levels of bioactivation and detoxification pathways.
Bladeren, Peter J. van +8 more
core
Molecular Nutrition &Food Research, Volume 70, Issue 9, 13 May 2026.ABSTRACT Gallic acid (GA), a plant‐derived phenolic compound, is evolving from a general antioxidant into a specific molecular modulator and a functional building block for advanced biomedical materials. This review synthesizes recent insights underpinned by GA's “redox duality”—its capacity to act as either a radical scavenger or a pro‐oxidant.
Woo Hyun Park
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Review Article: Targeting Peroxisome Proliferator‐Activated Receptors in Primary Biliary Cholangitis
Alimentary Pharmacology &Therapeutics, Volume 63, Issue 9, Page 1215-1235, May 2026.Peroxisome proliferator‐activated receptor (PPAR) agonists have emerged as important second‐line treatments in primary biliary cholangitis, with profiles influenced by different selectivity for α‐, δ‐ and γ‐isoforms. PPAR‐α and PPAR‐δ agonism improve cholestasis, with inflammation reduced via all isoforms. PPAR‐δ agonism also reduces pruritus.
Jörn M. Schattenberg +8 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 10, Page 2307-2323, May 2026.Background and purpose Opioids targeting the μ opioid receptor remain largely ineffective in neuropathic pain conditions, emphasizing the need for novel therapeutic strategies. MP135 was reported to reduce thermal nociception in naive animals by activating μ‐δ opioid receptor heteromers.
Perrine Inquimbert +13 more
wiley +1 more source
Frontiers in MicrobiologyCarbon catabolite repression (CCR) is a highly conserved mechanism that regulates carbon source utilization in Streptomyces. CCR has a negative impact on secondary metabolite fermentation, both in industrial and research settings.
Chen Tao +8 more
doaj +1 more source
Citation: 'glucuronide' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.09798 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire +1 more source
Predicting Pharmacokinetic Variability and Drug Interaction Risk Using Omics‐Based Biomarkers
Clinical and Translational Science, Volume 19, Issue 5, May 2026.ABSTRACT Interindividual variability in drug pharmacokinetics and susceptibility to drug–drug interactions remain major barriers in precision dosing, particularly for narrow therapeutic index drugs. While genetic factors contribute, much variability arises from dynamic influences such as physiology, disease, age, diet, microbiome, and concomitant ...
Bhagwat Prasad
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Rewiring Steroidal Metabolic Pathways for Diosgenin Production in Solanum nigrum
Plant Biotechnology Journal, Volume 24, Issue 5, Page 3032-3047, May 2026.ABSTRACT Diosgenin is a key starting material for the synthesis of steroidal drugs, such as corticosteroids and sex hormones. While the primary commercial source of diosgenin is the tubers of Dioscorea spp., identifying alternative plant hosts capable of diosgenin biosynthesis could enhance its production.
Jongbu Lim +16 more
wiley +1 more source