Results 61 to 70 of about 49,196 (193)
Frontiers in Oncology, 2019 High expression of the metabolic enzyme UDP-glucuronosyltransferase UGT2B17 in chronic lymphocytic leukemia (CLL) cells was associated with poor prognosis in two independent studies. However, the underlying mechanism remains unknown. We hypothesized that
Eric P. Allain +9 more
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Detoxification of 1,2-dihydroxy- 4-allylbenzene, a major phenolic compound in Piper betle, through glucuronidation using S9 protein of rat liver (Sprague Dawley) [PDF]
Pharmaciana, 2018 1,2-dihydroxy- 4-allylbenzene (DHAB) is a major compound in Piper betle leaf and also a metabolite of safrole metabolism. Epidemilogic studies showed people who have betel quid chewing habit are related to the incidence of oral submucous fibrosis and/or ...
Erryana Martati
doaj +1 more source
Effect of COMT and UGT1A Variants on Clinical Response to Opicapone in Parkinson's Disease
Movement Disorders Clinical Practice, EarlyView.Abstract Background Parkinson's disease (PD) is the second most common neurodegenerative disease. Symptomatic treatment is based on dopaminergic replacement. With disease progression, the initial benefit of levodopa becomes inconsistent, and motor complications emerge.
Elena Ojeda‐Lepe +15 more
wiley +1 more source
Antiepileptic Drug Disposition in Pregnancy
Pediatric Neurology Briefs, 2013 Investigators at the Karolinska Institute, Stockholm, Sweden; and centers in Oslo, Norway, and Milan, Italy, reviewed the literature on gestational effects on pharmacokinetics of older and newer antiepileptic drugs (AEDs).
J Gordon Millichap
doaj +1 more source
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai +6 more
wiley +1 more source
, 2008 Glucuronidation is an important pathway in the metabolism of protocatechuic aldehyde (3,4-dihydroxybenzaldehyde, PAL). However, the metabolites and primary UDP-glucuronosyltransferase (UGT) isozymes responsible for PAL glucuronidation remain to be ...
杨凌, 邹汉法, 刘慧鑫
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Glucuronidation, a New Metabolic Pathway for Pyrrolizidine Alkaloids
, 2010 Pyrrolizidine alkaloids (PAS) possess significant hepatotoxicity to humans and animals after metabolic activation by liver P450 enzymes. Metabolism pathways of PAs have been studied for several decades, including metabolic activation, hydroxylation, N ...
Wang, Chang-Hong +10 more
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CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 510-522, March 2025.Abstract Topiramate (TPM) is a broad‐spectrum antiepileptic drug (AED) commonly prescribed for approved and off‐label uses. Routine monitoring is suggested for clinical usage of TPM in special population due to its broad side effect profile. Therefore, it is crucial to further explore its pharmacokinetic characteristics.
Shuqing Chen +6 more
wiley +1 more source
In vitro glucuronidation of trans-Piceid and trans-Piceatannol by human liver microsomes
OENO One, 2008 Aims : The aim of the present investigation was to establish glucuronidation of trans-resveratrol derivates in the liver. Stilbenes are naturally occurring polyphenolic compounds which have been reported to have potential preventive activities in human ...
Caroline Henry-Vitrac +5 more
doaj +1 more source
In vitro Investigation of Glucuronidation of Magnolol: UGT2B7, a Major Responsible Isoform in HLMs
, 2010 Background: Magnolol, a biphenyl phenol, is a major active component in Magnolia Officinalis (also known as the traditional Chinese Medicine Houpu), which is used to treat mental disturbance and gastrointestinal disorder.
葛广波, 杨凌, 朱亮亮, 刘慧鑫
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